Articles with "bordetella pertussis" as a keyword



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Modeling the Effect of Oxidative Stress on Bordetella pertussis Fermentations.

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Published in 2023 at "Biotechnology progress"

DOI: 10.1002/btpr.3335

Abstract: A mathematical model is proposed for Bordetella pertussis with the main goal to better understand and describe the relation between cell growth, oxidative stress and NADPH levels under different oxidative conditions. The model is validated… read more here.

Keywords: stress; oxidative stress; bordetella pertussis; model ... See more keywords
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Nucleobase Modified Adefovir (PMEA) Analogues as Potent and Selective Inhibitors of Adenylate Cyclases from Bordetella pertussis and Bacillus anthracis

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Published in 2018 at "ChemMedChem"

DOI: 10.1002/cmdc.201800332

Abstract: A series of 13 acyclic nucleoside phosphonates (ANPs) as bisamidate prodrugs was prepared. Five compounds were found to be non‐cytotoxic and selective inhibitors of Bordetella pertussis adenylate cyclase toxin (ACT) in J774A.1 macrophage cell‐based assays.… read more here.

Keywords: potent selective; adenylate cyclases; bacillus anthracis; bordetella pertussis ... See more keywords
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How Genomics Is Changing What We Know About the Evolution and Genome of Bordetella pertussis.

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Published in 2019 at "Advances in experimental medicine and biology"

DOI: 10.1007/5584_2019_401

Abstract: The evolution of Bordetella pertussis from a common ancestor similar to Bordetella bronchiseptica has occurred through large-scale gene loss, inactivation and rearrangements, largely driven by the spread of insertion sequence element repeats throughout the genome.… read more here.

Keywords: evolution; bordetella pertussis; pertussis; genomics changing ... See more keywords
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Clinical-epidemiological study of Bordetella pertussis infection in the Gran Canaria island in the period, 2008–2016☆☆☆

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Published in 2018 at "Anales De Pediatria"

DOI: 10.1016/j.anpede.2017.10.007

Abstract: Abstract Objective Describe the epidemiological and clinical pattern of Bordetella pertussis infection (whooping cough) among hospitalised infants less than one year-old in a paediatric hospital in Gran Canaria. Patients and methods A retrospective review of… read more here.

Keywords: gran canaria; infection; bordetella pertussis; pertussis infection ... See more keywords
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Zn2+-dependent autocatalytic activity of the Bordetella pertussis CyaA-hemolysin.

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Published in 2017 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2017.02.113

Abstract: Proteolytic degradation of the ∼100-kDa isolated RTX (Repeat-in-ToXin) subdomain (CyaA-RTX) of the Bordetella pertussis CyaA-hemolysin (CyaA-Hly) was evidently detected upon solely-prolonged incubation. Here, a truncated CyaA-Hly fragment (CyaA-HP/BI) containing hydrophobic and acylation regions connected with… read more here.

Keywords: zn2 dependent; cyaa; cyaa rtx; bordetella pertussis ... See more keywords
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Impact of oxidative stress on protein production by Bordetella pertussis for vaccine production

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Published in 2019 at "Biochemical Engineering Journal"

DOI: 10.1016/j.bej.2019.107359

Abstract: Abstract The response of Bordetella pertussis to induced oxidative stress during fermentation was assessed. B. pertussis is the causal agent of whooping cough in humans and purified pertactin (PRN) is used as one of the… read more here.

Keywords: stress; oxidative stress; bordetella pertussis; protein production ... See more keywords
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Genetic analysis of clinical and vaccine strains of Bordetella pertussis by Pulsed-Field Gel Electrophoresis (PFGE), Multi Locus Sequence Typing (MLST) and serotyping.

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Published in 2019 at "Comparative immunology, microbiology and infectious diseases"

DOI: 10.1016/j.cimid.2019.03.010

Abstract: In spite of high vaccination coverage in the Expanded Program of Immunization (EPI), pertussis has not been eradicated yet and the re-emergence of the disease is still reported worldwide. The genetic divergence study of circulating… read more here.

Keywords: vaccine strains; sequence typing; pertussis; strains bordetella ... See more keywords
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Investigation of temporal and spatial heterogeneities of the immune responses to Bordetella pertussis infection in the lung and spleen of mice via analysis and modeling of dynamic microarray gene expression data

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Published in 2019 at "Infectious Disease Modelling"

DOI: 10.1016/j.idm.2019.06.001

Abstract: Bordetella pertussis (B. pertussis) is the causative agent of pertussis, also referenced as whooping cough. Although pertussis has been appropriately controlled by routine immunization of infants, it has experienced a resurgence since the beginning of… read more here.

Keywords: analysis; infection; bordetella pertussis; pertussis infection ... See more keywords
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SARS – CoV-2: Reasons of epidemiology of severe ill disease cases and therapeutic approach using trivalent vaccine (tetanus, diphtheria and Bordetella pertussis)

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Published in 2020 at "Medical Hypotheses"

DOI: 10.1016/j.mehy.2020.109779

Abstract: Abstract The novel coronavirus COVID-19 follows transmission route and clinical presentation of all community-acquired coronaviruses. Instead, the rate of transmission is significative higher, with a faster spread of the virus responsible of the worldwide outbreak… read more here.

Keywords: bordetella pertussis; tetanus diphtheria; immune system; epidemiology ... See more keywords
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Serological study of Bordetella Pertussis, Mycoplasma Pneumonia and Chlamydia Pneumonia in Iranian hajj pilgrims with prolonged cough illnesses: A follow-up study.

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Published in 2017 at "Respiratory medicine"

DOI: 10.1016/j.rmed.2017.10.009

Abstract: INTRODUCTION Hajj pilgrimage is the biggest and longest mass gathering in the Muslim world. Annually, about 50% of more than 2.5 million pilgrims participating in this ritual get involved in severe devastating coughs. Most coughs… read more here.

Keywords: chlamydia pneumonia; hajj; bordetella pertussis; study ... See more keywords
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The characterization of Bordetella pertussis strains isolated in the Central-Western region of Brazil suggests the selection of a specific genetic profile during 2012–2014 outbreaks

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Published in 2017 at "Epidemiology and Infection"

DOI: 10.1017/s0950268816003332

Abstract: SUMMARY Pertussis is a worldwide acute respiratory disease caused by the bacterium Bordetella pertussis. Despite high vaccine coverage, the bacterium continues to circulate in populations and is still one of the most common vaccine-preventable diseases.… read more here.

Keywords: isolated central; bordetella pertussis; strains isolated; pertussis strains ... See more keywords