Articles with "boron neutron" as a keyword



Exosome‐Coated 10B Carbon Dots for Precise Boron Neutron Capture Therapy in a Mouse Model of Glioma In Situ

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Published in 2021 at "Advanced Functional Materials"

DOI: 10.1002/adfm.202100969

Abstract: Novel boron‐containing carbon dots (BCDs) are designed and prepared for boron neutron capture therapy (BNCT) with superior water solubility and excellent optical property for tracking 10B in vitro and in vivo. Encapsulation of BCDs using… read more here.

Keywords: boron; glioma; bcd exos; boron neutron ... See more keywords

Tumor Redox‐Responsive Minimalist B/Fe Nano‐Chains for Chemodynamically Enhanced Ferroptosis and Synergistic Boron Neutron Capture Therapy

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Published in 2024 at "Advanced Functional Materials"

DOI: 10.1002/adfm.202407468

Abstract: Boron neutron capture therapy (BNCT) as a binary targeted particle radiotherapy strategy has shown potent anti‐cancer potential. However, biological barriers and restricted blood supply pose challenges in achieving adequate boron concentration within deep‐seated tumor lesions.… read more here.

Keywords: boron neutron; enhanced ferroptosis; therapy; boron ... See more keywords

Engineering Novel Targeted Boron-10-Enriched Theranostic Nanomedicine to Combat against Murine Brain Tumors via MR Imaging-Guided Boron Neutron Capture Therapy.

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Published in 2017 at "Advanced materials"

DOI: 10.1002/adma.201700850

Abstract: Glioblastoma multiforme (GBM) is a very common type of "incurable" malignant brain tumor. Although many treatment options are currently available, most of them eventually fail due to its recurrence. Boron neutron capture therapy (BNCT) emerges… read more here.

Keywords: capture therapy; boron neutron; neutron capture; boron ... See more keywords

Tumor Eradication by Boron Neutron Capture Therapy with 10 B-enriched Hexagonal Boron Nitride Nanoparticles Grafted with Poly(glycerol).

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Published in 2023 at "Advanced materials"

DOI: 10.1002/adma.202301479

Abstract: Boron neutron capture therapy (BNCT) has emerged as a treatment modality with high precision and efficacy of intractable tumors. At the core of effective tumor BNCT are 10 B carriers with facile preparation as well as… read more here.

Keywords: enriched hexagonal; neutron capture; boron; boron neutron ... See more keywords

Next generation of boron neutron capture therapy (BNCT) agents for cancer treatment.

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Published in 2023 at "Medicinal research reviews"

DOI: 10.1002/med.21964

Abstract: Boron neutron capture therapy (BNCT) is one of the most promising treatments among neutron capture therapies due to its long-term clinical application and unequivocally obtained success during clinical trials. Boron drug and neutron play an equivalent crucial… read more here.

Keywords: therapy bnct; neutron capture; boron; boron neutron ... See more keywords

Block copolymer‐boron cluster conjugate for effective boron neutron capture therapy of solid tumors

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Published in 2017 at "Journal of Controlled Release"

DOI: 10.1016/j.jconrel.2017.03.036

Abstract: &NA; Boron neutron capture therapy is a promising tumor treatment method, though its wide application has been limited due to the poor tumor selectivity and intracellular delivery of 10B‐compounds. Here, block copolymer‐boron cluster conjugate based… read more here.

Keywords: capture therapy; block copolymer; boron neutron; neutron capture ... See more keywords
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Sensing changes in tumor during boron neutron capture therapy using PET with a collimator: Simulation study

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Published in 2020 at "Nuclear Engineering and Technology"

DOI: 10.1016/j.net.2020.02.014

Abstract: Abstract The purpose of this study was to demonstrate the feasibility of sensing changes in a tumor during boron neutron capture therapy (BNCT) using a Monte Carlo simulation tool. In the simulation, an epi-thermal neutron… read more here.

Keywords: neutron; tumor boron; boron neutron; sensing changes ... See more keywords
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Design of a scintillator-based prompt gamma camera for boron-neutron capture therapy: Comparison of SrI2 and GAGG using Monte-Carlo simulation

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Published in 2020 at "Nuclear Engineering and Technology"

DOI: 10.1016/j.net.2020.07.010

Abstract: Abstract Boron–neutron capture therapy (BNCT) is a cancer treatment method that exploits the high neutron reactivity of boron. Monitoring the prompt gamma rays (PGs) produced during neutron irradiation is essential for ensuring the accuracy and… read more here.

Keywords: neutron; boron neutron; scintillator; neutron capture ... See more keywords

Boron Neutron Capture Therapy Enhanced by Boronate Ester Polymer Micelles: Synthesis, Stability, and Tumor Inhibition Studies

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Published in 2024 at "Biomacromolecules"

DOI: 10.1021/acs.biomac.4c00298

Abstract: Boron neutron capture therapy (BNCT) targets invasive, radioresistant cancers but requires a selective and high B-10 loading boron drug. This manuscript investigates boron-rich poly(ethylene glycol)-block-(poly(4-vinylphenyl boronate ester)) polymer micelles synthesized via atom transfer radical polymerization… read more here.

Keywords: ester polymer; boron neutron; neutron capture; tumor ... See more keywords
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Design, Synthesis, and Biological Evaluation of Boron-Containing Macrocyclic Polyamines and Their Zinc(II) Complexes for Boron Neutron Capture Therapy

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Published in 2021 at "Journal of Medicinal Chemistry"

DOI: 10.1021/acs.jmedchem.1c00445

Abstract: Boron neutron capture therapy (BNCT) is a binary therapeutic method for cancer treatment based on the use of a combination of a cancer-specific drug containing boron-10 (10B) and thermal neutron irradiation. For successful BNCT, 10B-containing… read more here.

Keywords: capture therapy; boron neutron; neutron capture; cancer ... See more keywords

The Development of Boron Analysis and Imaging in Boron Neutron Capture Therapy (BNCT).

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Published in 2022 at "Molecular pharmaceutics"

DOI: 10.1021/acs.molpharmaceut.1c00810

Abstract: Boron neutron capture therapy (BNCT) is a selective biological targeted nuclide technique for cancer therapy. It has the following attractive features: good targeting, high effectiveness, and causes slight damage to surrounding healthy tissue compared with… read more here.

Keywords: therapy bnct; neutron capture; therapy; boron ... See more keywords