Hi3 + 3: A model-assisted dose-finding design borrowing historical data.
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DOI: 10.1016/j.cct.2021.106437
Abstract: BACKGROUND In phase I clinical trials, historical data may be available through multi-regional programs, reformulation of the same drug, or previous trials for a drug under the same class. Statistical designs that borrow information from… read more here.
Keywords: dose finding; borrowing historical; historical data; safety ... See more keywords