DKK1 Suppresses WWP2 to Enhance Bortezomib Resistance in Multiple Myeloma via Regulating GLI2 Ubiquitination.
Sign Up to like & getrecommendations! Published in 2021 at "Carcinogenesis"
DOI: 10.1093/carcin/bgab086
Abstract: Bortezomib-based chemotherapy represents the most prevalent regimens for multiple myeloma (MM), whereas acquired drug resistance remains a major obstacle. Myeloma cells often produce excessive amount of dickkopf-1 (DKK1), giving rise to myeloma bone disease (MBD).… read more here.
Keywords: multiple myeloma; bortezomib; bortezomib resistance; dkk1 ... See more keywords
Circ_0005615 contributes to the progression and Bortezomib resistance of multiple myeloma by sponging miR-185-5p and upregulating IRF4
Sign Up to like & getrecommendations! Published in 2022 at "Anti-Cancer Drugs"
DOI: 10.1097/cad.0000000000001378
Abstract: Circular RNAs (circRNAs) have been shown to play critical regulatory roles in multiple myeloma progression. Here, we aimed to explore the biologic role of circ_0005615 in multiple myeloma progression and its associated mechanism. Cell counting… read more here.
Keywords: mir 185; multiple myeloma; bortezomib resistance; circ 0005615 ... See more keywords
Proteomic Analysis Identifies Mechanism(s) of Overcoming Bortezomib-Resistance Via Targeting Ubiquitin Receptor Rpn13
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DOI: 10.1182/blood-2019-130236
Abstract: Introduction Our studies have focused on delineating ubiquitin proteasome pathway signaling with a goal to identify and validate novel therapeutic targets to overcome proteasome-inhibitor-resistance in multiple myeloma (MM). Our siRNA screening studies showed ubiquitin Receptor… read more here.
Keywords: bortezomib resistance; sod1; ra190; rpn13 ... See more keywords
Review on Bortezomib Resistance in Multiple Myeloma and Potential Role of Emerging Technologies
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DOI: 10.3390/ph16010111
Abstract: Multiple myeloma is a hematological cancer type. For its treatment, Bortezomib has been widely used. However, drug resistance to this effective chemotherapeutic has been developed for various reasons. 2D cell cultures and animal models have… read more here.
Keywords: disease; resistance; resistance multiple; multiple myeloma ... See more keywords