Effect of amphiphilic graft co‐polymer‐carrier on physical stability of bosentan nanocomposite: Assessment of solubility, dissolution and bioavailability
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmaceutics and Biopharmaceutics"
DOI: 10.1016/j.ejpb.2017.06.024
Abstract: Graphical abstract Figure. No Caption available. ABSTRACT Bosentan is a dual endothelin receptor antagonist used in the treatment of pulmonary arterial hypertension (PAH). But the solubility and bioavailability of this drug are poor, which has… read more here.
Keywords: bioavailability; drug; graft polymer; solubility ... See more keywords
Additive Protective Effects of Sacubitril/Valsartan and Bosentan on Vascular Remodeling in Experimental Pulmonary Hypertension.
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DOI: 10.1093/cvr/cvaa200
Abstract: AIMS Although right ventricular (RV) function is an important determinant of morbidity and mortality in patients with pulmonary arterial hypertension (PAH), there is no treatment targeting directly the RV. We therefore evaluate the efficacy of… read more here.
Keywords: sacubitril valsartan; lcz 696; vascular remodeling; hypertension ... See more keywords
P020 Audit of bosentan use in Rapid Access to Digital Ulcer Clinic (RADUC) in systemic sclerosis: a single-centre experience
Sign Up to like & getrecommendations! Published in 2023 at "Rheumatology"
DOI: 10.1093/rheumatology/kead104.062
Abstract: Systemic sclerosis (SSc) is an autoimmune disease characterised by microvascular injury and excessive fibrotic responses. About 55% of SSc patients develop digital ulcers (DUs). The revised “Clinical commissioning policy for the prescription of sildenafil and… read more here.
Keywords: systemic sclerosis; bosentan; rapid access; dus ... See more keywords
Comparative assessment of efficacy and safety of ambrisentan and bosentan in patients with pulmonary arterial hypertension: A meta-analysis.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of clinical pharmacy and therapeutics"
DOI: 10.1111/jcpt.13481
Abstract: WHAT IS KNOWN AND OBJECTIVE Two endothelin receptor antagonists, ambrisentan and bosentan, have been demonstrated to be effective individually compared with placebo in the treatment of patients with pulmonary arterial hypertension (PAH). This network meta-analysis… read more here.
Keywords: bosentan patients; sucra score; score ambrisentan; ambrisentan bosentan ... See more keywords
Predictive model of bosentan-induced liver toxicity in Japanese patients with pulmonary arterial hypertension.
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DOI: 10.1139/cjpp-2019-0656
Abstract: Bosentan, an endothelin receptor antagonist, has been widely used as a first-line medication for the treatment of pulmonary arterial hypertension (PAH). However, liver dysfunction is a major side effect of bosentan treatment that could hamper… read more here.
Keywords: liver toxicity; bosentan induced; model; induced liver ... See more keywords
Plasma Drug Concentrations in Patients with Pulmonary Arterial Hypertension on Combination Treatment
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DOI: 10.1159/000470916
Abstract: Background: Combination therapy with the phosphodiesterase type 5 inhibitors (PDE-5i) sildenafil or tadalafil and the endothelin receptor antagonists (ERA) bosentan, ambrisentan, or macitentan may cause mutual pharmacokinetic interactions in patients with pulmonary arterial hypertension (PAH).… read more here.
Keywords: combination; mom; drug concentrations; plasma drug ... See more keywords
Bosentan for patients with steroid-resistant pulmonary sarcoidosis: a randomised controlled trial.
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DOI: 10.4414/smw.2018.14677
Abstract: BACKGROUND Sarcoidosis is a disorder of unknown aetiology. Most patients have steroid-responsive disease, but side effects and steroid resistance may necessitate alternative treatments. Endothelin has in-vitro fibrogenic activity and the endothelin system is activated in… read more here.
Keywords: trial; capacity; patients steroid; steroid resistant ... See more keywords