Potential utilization of a lambda carrageenan polysaccharide, derived from a cultivated, clonal strain of the red seaweed Chondrus crispus (Irish moss) against toxic actions of venom of Bothrops jararaca and B. jararacussu snakes
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Applied Phycology"
DOI: 10.1007/s10811-020-02229-7
Abstract: Snakebites are a serious occupational problem affecting rural populations of tropical and sub-tropical, developing countries. Envenomation caused by the snakes Bothrops jararaca and B. jararacussu is characterized by local pain, edema, hemorrhage, tissue necrosis, and… read more here.
Keywords: jararaca jararacussu; clonal strain; polysaccharide; crispus ... See more keywords
Differences between renal effects of venom from two Bothrops jararaca populations from southeastern and southern Brazil
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DOI: 10.1016/j.toxicon.2016.11.249
Abstract: ABSTRACT Components from animal venoms may vary according to the snake's age, gender and region of origin. Recently, we performed a proteomic analysis of Bothrops jararaca venom from southern (BjSv) and southeastern (BjSEv) Brazil, showing… read more here.
Keywords: bjv south; bjsv; renal effects; bjv ... See more keywords
Abstract A60: Full-length transcripts identification from deep transcriptomic analysis of Bothrops jararaca venom gland
Sign Up to like & getrecommendations! Published in 2018 at "Clinical Cancer Research"
DOI: 10.1158/1557-3265.tcm17-a60
Abstract: Introduction: Head and neck cancer is a collective term defined by topographic and anatomic features to describe malignant tumors of the upper aerodigestive tract. Despite the different strategies used in the treatment of head and… read more here.
Keywords: venom gland; full length; jararaca venom; length transcripts ... See more keywords
CB1 receptor signalling mediates cannabidiol-induced panicolytic-like effects and defensive antinociception impairment in mice threatened by Bothrops jararaca lancehead pit vipers
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Psychopharmacology"
DOI: 10.1177/02698811221115755
Abstract: Background: Cannabis sativa-derived substances such as cannabidiol (CBD) have attracted increasing clinical interest and consist in a new perspective for treating some neurological and psychiatric diseases. Aims: The aim of this work was to investigate… read more here.
Keywords: antinociception; bothrops jararaca; mice threatened; cbd ... See more keywords
Allopurinol attenuates acute kidney injury following Bothrops jararaca envenomation
Sign Up to like & getrecommendations! Published in 2017 at "PLoS Neglected Tropical Diseases"
DOI: 10.1371/journal.pntd.0006024
Abstract: Snakebites have been recognized as a neglected public health problem in several tropical and subtropical countries. Bothrops snakebites frequently complicate with acute kidney injury (AKI) with relevant morbidity and mortality. To date, the only treatment… read more here.
Keywords: kidney injury; allo; acute kidney; bothrops jararaca ... See more keywords
Pain and Cellular Migration Induced by Bothrops jararaca Venom in Mice Selected for an Acute Inflammatory Response: Involvement of Mast Cells
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.779473
Abstract: Bothrops jararaca venom (BjV) can induce mast cell degranulation. In order to investigate the role of mast cells and the interference of the host genetic background in the inflammation induced by BjV, we have used… read more here.
Keywords: mast; bothrops jararaca; migration; mast cells ... See more keywords
Revisiting the Therapeutic Potential of Bothrops jararaca Venom: Screening for Novel Activities Using Connectivity Mapping
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DOI: 10.3390/toxins10020069
Abstract: Snake venoms are sources of molecules with proven and potential therapeutic applications. However, most activities assayed in venoms (or their components) are of hemorrhagic, hypotensive, edematogenic, neurotoxic or myotoxic natures. Thus, other relevant activities might… read more here.
Keywords: connectivity; revisiting therapeutic; jararaca venom; bothrops jararaca ... See more keywords
Extracellular Vesicles from Bothrops jararaca Venom Are Diverse in Structure and Protein Composition and Interact with Mammalian Cells
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DOI: 10.3390/toxins14110806
Abstract: Snake venoms are complex cocktails of non-toxic and toxic molecules that work synergistically for the envenoming outcome. Alongside the immediate consequences, chronic manifestations and long-term sequelae can occur. Recently, extracellular vesicles (EVs) were found in… read more here.
Keywords: jararaca venom; extracellular vesicles; bothrops jararaca; evs ... See more keywords
Cationic PLGA Nanoparticle Formulations as Biocompatible Immunoadjuvant for Serum Production and Immune Response against Bothrops jararaca Venom
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DOI: 10.3390/toxins14120888
Abstract: Snakebite envenoming represents a worldwide public health issue. Suitable technologies have been investigated for encapsulated recombinant or native proteins capable of inducing an effective and long-lasting adaptive immune response. Nanoparticles are colloidal dispersions that have… read more here.
Keywords: jararaca venom; bothrops jararaca; immune response; production ... See more keywords