Subjective versus objective symptom intensities ratings in cervical dystonia and hemifacial spasm across a botulinum neurotoxin cycle
Sign Up to like & getrecommendations! Published in 2021 at "Brain and Behavior"
DOI: 10.1002/brb3.2023
Abstract: Subjective symptom complaints often do not match the expert’s ratings in focal dystonia. Nonetheless, perceived symptom intensities drive compliance and outcome of botulinum neurotoxin (BoNT) treatment. read more here.
Keywords: symptom intensities; botulinum neurotoxin; dystonia;
Low energy shock wave‐delivered intravesical botulinum neurotoxin‐A potentiates antioxidant genes and inhibits proinflammatory cytokines in rat model of overactive bladder
Sign Up to like & getrecommendations! Published in 2020 at "Neurourology and Urodynamics"
DOI: 10.1002/nau.24511
Abstract: To study the effect of intravesical instillation of botulinum neurotoxin‐A (BoNT‐A) combined with low energy shock wave (LESW) for treatment of overactive bladder (OAB) in a rat model and to investigate its effect on the… read more here.
Keywords: botulinum neurotoxin; energy shock; overactive bladder; shock wave ... See more keywords
A simplified ultrasonography-guided approach for neurotoxin injection into the obliquus capitis inferior muscle in spasmodic torticollis
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Neural Transmission"
DOI: 10.1007/s00702-018-1866-4
Abstract: The obliquus capitis inferior (OCI) muscle may be crucially involved in generating the tremulous component of spasmodic torticollis. This study was undertaken to evaluate the efficacy of a simplified ultrasonography-guided approach of botulinum neurotoxin injection… read more here.
Keywords: botulinum neurotoxin; neurotoxin injection; neurotoxin; injection ... See more keywords
Utilizing Ayurvedic literature for the identification of novel phytochemical inhibitors of botulinum neurotoxin A.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2016.07.069
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Ayurveda, an ancient holistic system of health care practiced on the Indian subcontinent, utilizes a number of multi-plant formulations and is considered by many as a potential source for novel treatments, as well… read more here.
Keywords: ayurvedic literature; acoric acid; literature; botulinum neurotoxin ... See more keywords
Botulinum neurotoxin-A usage and training in cervical dystonia & spastic paresis: First results from the Ixcellence Network® survey
Sign Up to like & getrecommendations! Published in 2018 at "Annals of Physical and Rehabilitation Medicine"
DOI: 10.1016/j.rehab.2018.05.1225
Abstract: Introduction/Background Botulinum neurotoxin-A (BoNT-A) is commonly used as first line treatment for Cervical Dystonia (CD) and Spastic Paresis (SP). The Ixcellence Network® (IN) international survey aims to describe the current situation of training and practices… read more here.
Keywords: medicine; botulinum neurotoxin; training; cervical dystonia ... See more keywords
Botulinum Neurotoxin C Dual Detection through Immunological Recognition and Endopeptidase Activity Using Porous Silicon Interferometers.
Sign Up to like & getrecommendations! Published in 2022 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c00255
Abstract: Botulinum neurotoxins (BoNTs) are the most potent toxins known in nature produced by Clostridium botulinum strains, which can cause life-threatening diseases in both humans and animals. The latter is of serious environmental and economic concern,… read more here.
Keywords: neurotoxin dual; detection; activity; endopeptidase activity ... See more keywords
Plasma Metabolomic Changes in Children with Cerebral Palsy Exposed to Botulinum Neurotoxin.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.1c00711
Abstract: The long-term effect of botulinum neurotoxin A (BoNT-A) on children with cerebral palsy (CP) is unclear, and how the dynamic changes of metabolites impact the duration of effect remains unknown. To tackle this, we collected… read more here.
Keywords: effect; analysis; children cerebral; cerebral palsy ... See more keywords
Yeast Display Enables Identification of Covalent Single-Domain Antibodies against Botulinum Neurotoxin Light Chain A.
Sign Up to like & getrecommendations! Published in 2022 at "ACS chemical biology"
DOI: 10.1021/acschembio.2c00574
Abstract: While covalent drug discovery is reemerging as an important route to small-molecule therapeutic leads, strategies for the discovery and engineering of protein-based irreversible binding agents remain limited. Here, we describe the use of yeast display… read more here.
Keywords: yeast display; display; single domain; neurotoxin light ... See more keywords
Reprogramming the Cleavage Specificity of Botulinum Neurotoxin Serotype B1.
Sign Up to like & getrecommendations! Published in 2022 at "ACS synthetic biology"
DOI: 10.1021/acssynbio.2c00235
Abstract: Proteases with reprogrammed specificity for nonnative substrates are highly desired in synthetic biology and biomedicine. However, generating reprogrammed proteases that are orthogonal and highly specific for a new target has been a major challenge. In… read more here.
Keywords: protease; neurotoxin serotype; specificity; biology ... See more keywords
Functional Deimmunization of Botulinum Neurotoxin Protease Domain via Computationally Driven Library Design and Ultrahigh-Throughput Screening.
Sign Up to like & getrecommendations! Published in 2023 at "ACS synthetic biology"
DOI: 10.1021/acssynbio.2c00426
Abstract: Botulinum neurotoxin serotype A (BoNT/A) is a widely used cosmetic agent that also has diverse therapeutic applications; however, adverse antidrug immune responses and associated loss of efficacy have been reported in clinical uses. Here, we… read more here.
Keywords: botulinum neurotoxin; throughput screening; ultrahigh throughput; design ultrahigh ... See more keywords
Non-toxic fragment of botulinum neurotoxin type A and monomethyl auristatin E conjugate for targeted therapy for neuroendocrine tumors
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Gene Therapy"
DOI: 10.1038/s41417-020-0167-x
Abstract: Surgical resection is the only cure for neuroendocrine tumors (NETs). However, widespread metastases have already occured by the time of initial diagnosis in many cases making complete surgical removal impossible. We developed a recombinant heavy-chain… read more here.
Keywords: botulinum neurotoxin; rhcr; neuroendocrine tumors; monomethyl auristatin ... See more keywords