Updates on Botulinum Neurotoxins in Dermatology
Sign Up to like & getrecommendations! Published in 2019 at "American Journal of Clinical Dermatology"
DOI: 10.1007/s40257-019-00482-2
Abstract: Being the most popular non-surgical cosmetic procedure, botulinum neurotoxin (BoNT) injections are increasingly of interest to all cosmetic practitioners across the globe. This article serves to update readers on the new botulinum toxins that are… read more here.
Keywords: neurotoxins dermatology; updates botulinum; dermatology; dermatology updates ... See more keywords
Genomic insights into the evolution and ecology of botulinum neurotoxins
Sign Up to like & getrecommendations! Published in 2018 at "Pathogens and Disease"
DOI: 10.1093/femspd/fty040
Abstract: Abstract Clostridial neurotoxins, which include botulinum neurotoxins (BoNTs) and tetanus neurotoxins, have evolved a remarkably sophisticated structure and molecular mechanism fine‐tuned for the targeting and cleavage of vertebrate neuron substrates leading to muscular paralysis. How… read more here.
Keywords: insights evolution; botulinum neurotoxins; genomic insights; botulinum ... See more keywords
Re-engineering Botox
Sign Up to like & getrecommendations! Published in 2021 at "Science"
DOI: 10.1126/science.abg3535
Abstract: Botulinum neurotoxin is altered to recognize a different substrate Some of the most toxic substances known are the botulinum neurotoxins. The most well-known member of this toxin family is Botulinum neurotoxin A1, famously known as… read more here.
Keywords: botulinum; botulinum neurotoxins; botox; engineering botox ... See more keywords
Embryonic Stem Cell-Derived Neurons Grown on Multi-Electrode Arrays as a Novel In vitro Bioassay for the Detection of Clostridium botulinum Neurotoxins
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2017.00073
Abstract: Clostridium botulinum neurotoxins (BoNTs) are the most poisonous naturally occurring protein toxins known to mankind and are the causative agents of the severe and potentially life-threatening disease botulism. They are also known for their application… read more here.
Keywords: clostridium botulinum; cell derived; derived neurons; botulinum neurotoxins ... See more keywords
Emerging Opportunities in Human Pluripotent Stem-Cells Based Assays to Explore the Diversity of Botulinum Neurotoxins as Future Therapeutics
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22147524
Abstract: Botulinum neurotoxins (BoNTs) are produced by Clostridium botulinum and are responsible for botulism, a fatal disorder of the nervous system mostly induced by food poisoning. Despite being one of the most potent families of poisonous… read more here.
Keywords: human pluripotent; based assays; botulinum neurotoxins; pluripotent stem ... See more keywords
Why Are Botulinum Neurotoxin-Producing Bacteria So Diverse and Botulinum Neurotoxins So Toxic?
Sign Up to like & getrecommendations! Published in 2019 at "Toxins"
DOI: 10.3390/toxins11010034
Abstract: Botulinum neurotoxins (BoNTs) are the most lethal toxins among all bacterial, animal, plant and chemical poisonous compounds. Although a great effort has been made to understand their mode of action, some questions are still open.… read more here.
Keywords: neurotoxin producing; producing bacteria; botulinum neurotoxin; botulinum neurotoxins ... See more keywords
Introduction to the Toxins Special Issue on Botulinum Neurotoxins in the Nervous System: Future Challenges for Novel Indications
Sign Up to like & getrecommendations! Published in 2020 at "Toxins"
DOI: 10.3390/toxins12090601
Abstract: Botulinum toxins (BoNTs) are a true wonder of nature [...]. read more here.
Keywords: introduction toxins; issue botulinum; botulinum neurotoxins; botulinum ... See more keywords
Engineering Botulinum Neurotoxins for Enhanced Therapeutic Applications and Vaccine Development
Sign Up to like & getrecommendations! Published in 2020 at "Toxins"
DOI: 10.3390/toxins13010001
Abstract: Botulinum neurotoxins (BoNTs) show increasing therapeutic applications ranging from treatment of locally paralyzed muscles to cosmetic benefits. At first, in the 1970s, BoNT was used for the treatment of strabismus, however, nowadays, BoNT has multiple… read more here.
Keywords: therapeutic applications; engineering botulinum; neurotoxins enhanced; botulinum neurotoxins ... See more keywords
High Conservation of Tetanus and Botulinum Neurotoxins Cleavage Sites on Human SNARE Proteins Suggests That These Pathogens Exerted Little or No Evolutionary Pressure on Humans
Sign Up to like & getrecommendations! Published in 2017 at "Toxins"
DOI: 10.3390/toxins9120404
Abstract: The Genome Aggregation Database presently contains >120,000 human genomes. We searched in this database for the presence of mutations at the sites of tetanus (TeNT) and botulinum neurotoxins (BoNTs) cleavages of the three SNARE proteins:… read more here.
Keywords: snare; snare proteins; botulinum neurotoxins; cleavage sites ... See more keywords