Free Energy Profiles Relating With Conformational Transition of the Switch Domains Induced by G12 Mutations in GTP-Bound KRAS
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DOI: 10.3389/fmolb.2022.912518
Abstract: Mutations of G12 in KRAS have been involved in different cancers. Multiple replica-Gaussian accelerated molecular dynamics (MR-GaMD) simulations are applied to investigate conformational changes of the switch domains caused by G12C, G12D and G12R. Free… read more here.
Keywords: bound kras; gtp bound; switch; free energy ... See more keywords