How CaV1.2-bound verapamil blocks Ca2+ influx into cardiomyocyte: Atomic level views.
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DOI: 10.1016/j.phrs.2018.11.017
Abstract: The first clinically used antiarrhythmic, antianginal and anti-hypertensive phenylalkylamine, verapamil's cardiovascular activity is inextricably linked to its ability to antagonize Ca2+ overload via blocking CaV1.2, a cardiac L-type Ca2+ channel of undisputed physiological and pharmacological… read more here.
Keywords: verapamil blocks; cav1 bound; atomic level; verapamil ... See more keywords