The liposome of trehalose dimycolate extracted from M. bovis BCG induces antitumor immunity via the activation of dendritic cells and CD8+ T cells
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Immunology, Immunotherapy"
DOI: 10.1007/s00262-021-02870-2
Abstract: Intravesical Bovis bacillus Calmette-Guérin (BCG) therapy is the most effective immunotherapy for bladder cancer, but it sometime causes serious side effects because of its inclusion of live bacteria. It is necessary to develop a more… read more here.
Keywords: lip tdm; trehalose dimycolate; tdm; bovis bcg ... See more keywords
Tissue specific diversification, virulence and immune response to Mycobacterium bovis BCG in a patient with an IFN-γ R1 deficiency
Sign Up to like & getrecommendations! Published in 2020 at "Virulence"
DOI: 10.1080/21505594.2020.1848108
Abstract: ABSTRACT Summary: We characterized Mycobacterium bovis BCG isolates found in lung and brain samples from a previously vaccinated patient with IFNγR1 deficiency. The isolates collected displayed distinct genomic and phenotypic features consistent with host adaptation… read more here.
Keywords: virulence; ifn deficiency; bovis bcg; brain ... See more keywords
Mycobacterium bovis BCG promotes IL-10 expression by establishing a SYK/PKCα/β positive autoregulatory loop that sustains STAT3 activation.
Sign Up to like & getrecommendations! Published in 2019 at "Pathogens and disease"
DOI: 10.1093/femspd/ftz032
Abstract: Mycobacterium ensures its survival inside macrophages and long-term infection by subverting the innate and adaptive immune response through the modulation of cytokine gene expression profiles. Different Mycobacterium species promote the expression of TGFβ and IL-10,… read more here.
Keywords: bcg promotes; mycobacterium; mycobacterium bovis; promotes expression ... See more keywords
TNFRp75‐dependent immune regulation of alveolar macrophages and neutrophils during early Mycobacterium tuberculosis and Mycobacterium bovis BCG infection
Sign Up to like & getrecommendations! Published in 2020 at "Immunology"
DOI: 10.1111/imm.13277
Abstract: TNF signalling through TNFRp55 and TNFRp75, and receptor shedding is important for immune activation and regulation. TNFRp75 deficiency leads to improved control of Mycobacterium tuberculosis (M. tuberculosis) infection, but the effects of early innate immune… read more here.
Keywords: mycobacterium; bcg infection; tuberculosis; tnfrp75 ... See more keywords
Endogenous and Exogenous KdpF Peptide Increases Susceptibility of Mycobacterium bovis BCG to Nitrosative Stress and Reduces Intramacrophage Replication
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2017.00115
Abstract: Emerging antibiotic resistance in pathogenic bacteria like Mycobacterium sp., poses a threat to human health and therefore calls for the development of novel antibacterial strategies. We have recently discovered that bacterial membrane peptides, such as… read more here.
Keywords: stress; bovis bcg; nitrosative stress; replication ... See more keywords
M. bovis BCG Moreau N-Terminal Loss Leads to a Less Stable Dodecin With Lower Flavin Binding Capacity
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2021.658888
Abstract: Tuberculosis still remains a concerning health problem worldwide. Its etiologic agent, Mycobacterium tuberculosis, continues to be the focus of research to unravel new prophylactic and therapeutic strategies against this disease. The only vaccine in use… read more here.
Keywords: binding capacity; dodecin; bovis bcg; bcg moreau ... See more keywords
Functional Analysis of Genetic Variations in Surfactant Protein D in Mycobacterial Infection and Their Association With Tuberculosis
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2018.01543
Abstract: Surfactant proteins (SPs)-A and -D are C-type lectins of the collectin family and function in the clearance of infectious particles in the lungs. Some polymorphisms of SPs that give rise to amino acid changes have… read more here.
Keywords: amino acid; infection; association; tuberculosis ... See more keywords
Complement Dependent and Independent Interaction Between Bovine Conglutinin and Mycobacterium bovis BCG: Implications in Bovine Tuberculosis
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2018.03159
Abstract: Bovine conglutinin, the first animal collectin to be discovered, is structurally very similar to Surfactant Protein D (SP-D). SP-D is known to interact with Mycobacterium tuberculosis, and the closely-related M. bovis, the causative agent of… read more here.
Keywords: rfbc; bovine; tuberculosis; bovis bcg ... See more keywords
Auxotrophic Mycobacterium bovis BCG: Updates and Perspectives
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DOI: 10.3390/vaccines10050802
Abstract: Mycobacterium bovis BCG has been used for a century as the only licensed vaccine against tuberculosis. Owing to its strong adjuvant properties, BCG has also been employed as an oncological immunotherapeutic as well as a… read more here.
Keywords: bcg; auxotrophic mycobacterium; bovis bcg; mycobacterium bovis ... See more keywords
Transcriptional and mycolic acids profiling in Mycobacterium bovis BCG in vitro show an effect for c-di-GMP and overlap between dormancy and biofilms.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of microbiology and biotechnology"
DOI: 10.4014/jmb.1911.11043
Abstract: Mycobacterium tuberculosis produce mycolic acids which are relevant for persistence, recalcitrance to antibiotics and defiance to host immunity. c-di-GMP is a second messenger involved in transition from planktonic cells to biofilms, whose levels are controlled… read more here.
Keywords: mycobacterium; gmp; mycolic acids; effect gmp ... See more keywords