In vivo anti‐inflammatory efficacy of the combined Bowman‐Birk trypsin inhibitor and genistein isoflavone, two biological compounds from soybean
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DOI: 10.1002/jbt.22406
Abstract: Soybean Bowman‐Birk protease inhibitor (BBI) and genistein, two biological compounds from soybean, are well‐known for their anti‐inflammatory, antioxidant, and anticancer activities. The aim of this study was designing a BBI‐genistein conjugate and then investigating its… read more here.
Keywords: anti inflammatory; bowman birk; two biological; bbi genistein ... See more keywords
Bowman‐Birk inhibitor modifies transcription of autophagy and apoptosis genes in an in vitro model of Alzheimer's disorder
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DOI: 10.1002/jcb.28391
Abstract: Alzheimer, a current neurodegenerative disorder has adverse effects on memory and behavior. β‐Amyloid peptide accumulations are the hallmarks of Alzheimer. Dysfunction of autophagy and apoptosis is detected in Alzheimer's disease. The effect of Bowman‐Birk inhibitor… read more here.
Keywords: autophagy apoptosis; model alzheimer; vitro model; birk inhibitor ... See more keywords
Biochemical properties of a bacterially-expressed Bowman-Birk inhibitor from Rhynchosia sublobata (Schumach.) Meikle seeds and its activity against gut proteases of Achaea janata.
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DOI: 10.1016/j.phytochem.2018.02.009
Abstract: Crude proteinase inhibitors (CPIs) extracted from the seeds of Rhynchosia sublobata, a wild relative of pigeon pea showed pronounced inhibitory activity on the larval gut trypsin-like proteases of lepidopteran insect pest - Achaea janata. Consequently,… read more here.
Keywords: achaea janata; bowman birk; trypsin; rhynchosia sublobata ... See more keywords
Soybean-derived Bowman-Birk inhibitor (BBI) blocks HIV entry into macrophages.
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DOI: 10.1016/j.virol.2017.08.030
Abstract: Bowman-Birk inhibitor (BBI) is a soybean-derived protease inhibitor that has anti-inflammation and anti-HIV effect. Here, we further investigated the anti-HIV action of BBI in macrophages, focusing on its effect on viral entry. We found that… read more here.
Keywords: birk inhibitor; hiv entry; bowman birk; entry ... See more keywords
Protein Separation Coacervation with Carboxymethyl Cellulose of Different Substitution Degree: Noninteracting Behavior of Bowman-Birk Chymotrypsin Inhibitor.
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DOI: 10.1021/acs.jafc.8b00091
Abstract: We first observed that protein/polysaccharide interaction exhibited noninteracting behavior which makes Bowman-Birk chymotrypsin inhibitor (BBI) always free of complexation, being separated from another protein with similar isoelectric points, Kunitz trypsin inhibitor (KTI). Turbidity titrations showed… read more here.
Keywords: protein; inhibitor; chymotrypsin; bowman birk ... See more keywords
Divergent Protein Synthesis of Bowman–Birk Protease Inhibitors, their Hydrodynamic Behavior and Co-crystallization with α-Chymotrypsin
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DOI: 10.1055/s-0036-1588840
Abstract: A divergent protein synthesis strategy was executed to effectively synthesize Bowman–Birk protease inhibitor (BBI) analogues using native chemical ligation of peptide hydrazides. Grafting selected residues from a potent trypsin inhibitor, sunflower trypsin inhibitor-1, onto the… read more here.
Keywords: protein; chymotrypsin; bowman birk; protein synthesis ... See more keywords