Multiple Functions of the DEAD-Box Helicase Vasa in Drosophila Oogenesis.
Sign Up to like & getrecommendations! Published in 2017 at "Results and problems in cell differentiation"
DOI: 10.1007/978-3-319-60855-6_6
Abstract: The DEAD-box helicase Vasa (Vas) has been most extensively studied in the fruit fly, Drosophila melanogaster, and numerous roles for it in germline development have been discovered. Here, we summarize the present state of knowledge… read more here.
Keywords: helicase vasa; box helicase; dead box;
DEAD-Box Helicase 18 Counteracts PRC2 to Safeguard Ribosomal DNA in Pluripotency Regulation.
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2019.12.021
Abstract: Embryonic stem cells (ESCs) exhibit high levels of ribosomal RNA (rRNA) transcription and ribosome biogenesis. Here, we reveal an unexpected role for an essential DEAD-box helicase, DDX18, in antagonizing the polycomb repressive complex 2 (PRC2)… read more here.
Keywords: box helicase; ddx18; counteracts prc2; dead box ... See more keywords
The DEAD-box helicase DDX56 is a conserved stemness regulator in normal and cancer stem cells.
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.108903
Abstract: Across the animal kingdom, adult tissue homeostasis is regulated by adult stem cell activity, which is commonly dysregulated in human cancers. However, identifying key regulators of stem cells in the milieu of thousands of genes… read more here.
Keywords: ddx56; box helicase; dead box; cancer ... See more keywords
Structure-function analysis of DEAD-box helicase DDX43.
Sign Up to like & getrecommendations! Published in 2022 at "Methods"
DOI: 10.1016/j.ymeth.2022.03.002
Abstract: DDX43 (DEAD-box helicase 43), also known as HAGE (helicase antigen gene), is a member of the DEAD-box protein family. It contains a K homology (KH) domain in its N terminus, a helicase core domain in… read more here.
Keywords: helicase; ddx43; domain; dead box ... See more keywords
DEAD-Box Helicase DDX3X as a Host Target against Emerging Viruses: New Insights for Medicinal Chemical Approaches.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c00755
Abstract: In recent years, globalization, global warming, and population aging have contributed to the spread of emerging viruses, such as coronaviruses (COVs), West Nile (WNV), Dengue (DENV), and Zika (ZIKV). The number of reported infections is… read more here.
Keywords: box helicase; dead box; emerging viruses; helicase ... See more keywords
Circular RNA PUM1 performs as a competing endogenous RNA of microRNA-340-5p to mediate DEAD-box helicase 5 to mitigate cerebral ischemia-reperfusion injury
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2068923
Abstract: ABSTRACT Cerebral ischemia-reperfusion damages local brain tissue and impairs brain function, but its specific pathogenesis is still uncertain. Recent studies have clarified circPUM1 is aberrantly elevated in cerebral ischemia-reperfusion injury; however, circPUM1ʹs function in cerebral… read more here.
Keywords: box helicase; microrna 340; cerebral ischemia; dead box ... See more keywords
DEAD-box helicase 56 functions as an oncogene promote cell proliferation and invasion in gastric cancer via the FOXO1/p21 Cip1/c-Myc signaling pathway
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2084235
Abstract: ABSTRACT DEAD-box helicase (DDX) family exerts a critical effect on cancer initiation and progression through alternative splicing, transcription and ribosome biogenesis. Increasing evidence has demonstrated that DEAD-box helicase 56 (DDX56) is over-expressed in several cancers,… read more here.
Keywords: cell; box helicase; ddx56; dead box ... See more keywords
DEAD-box helicase intrinsically disordered domains and structural dynamics of HIV-1 RNA are required to reveal DDX3X catalytic efficiency
Sign Up to like & getrecommendations! Published in 2025 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkaf834
Abstract: Abstract DEAD-Box helicases are enzymes that bind and remodel RNA and ribonucleoproteins. They are involved in almost every step of RNA metabolism. DEAD-Box helicases are thus major players of gene expression (dys)-regulation and intracellular parasite… read more here.
Keywords: box helicase; dead box; box; hiv rna ... See more keywords
A novel DEAH-box helicase 37 mutation associated with differences of sex development
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2023.1059159
Abstract: Objective To determine the genetic etiology of a family pedigree with two patients affected by differences of sex development (DSD). Methods Assess the clinical characteristics of the patients and achieve exome sequencing results and in… read more here.
Keywords: box helicase; sex development; differences sex; sex ... See more keywords
Targeting Hepatocellular Carcinoma Growth: Haprolid’s Inhibition of AKT Signaling Through DExH-Box Helicase 9 Downregulation
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DOI: 10.3390/cancers17030443
Abstract: Simple Summary Haprolid, a novel compound derived from Myxobacterium, has demonstrated selective toxicity against various tumor cells and effectively inhibits the growth of hepatocellular carcinoma. However, its molecular mechanism remains unclear. This study identified DExH-Box… read more here.
Keywords: dexh box; hepatocellular carcinoma; box helicase;
Herpes Simplex 2 Virus Depletes Cells of DEAD-Box Helicase 3 Protein by Packaging It into Virions
Sign Up to like & getrecommendations! Published in 2025 at "Viruses"
DOI: 10.3390/v17081124
Abstract: Human DEAD-box helicase 3 (DDX3) is a multifunctional RNA helicase implicated in mRNA unwinding and the regulation of gene expression. While DDX3 has been extensively studied in the context of RNA virus replication, its role… read more here.
Keywords: box helicase; virus; protein; ddx3 ... See more keywords