High mobility group box-1 (HMGB1) antagonist BoxA suppresses status epilepticus-induced neuroinflammatory responses associated with Toll-like receptor 2/4 down-regulation in rats
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DOI: 10.1016/j.brainres.2019.04.007
Abstract: It has been generally accepted that inflammatory responses induced by status epilepticus (SE) in the brain are associated with microglial activation. One important regulator of microglial activation is high mobility group box-1 (HMGB1) protein. HMGB1… read more here.
Keywords: status; hmgb1; status epilepticus; boxa ... See more keywords
High-Mobility Group Box 1 Inhibitor BoxA Alleviates Neuroinflammation-Induced Retinal Ganglion Cell Damage in Traumatic Optic Neuropathy
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DOI: 10.3390/ijms23126715
Abstract: Traumatic optic neuropathy (TON) is a significant cause of vision loss and irreversible blindness worldwide. It is defined as retinal ganglion cell death and axon degeneration caused by injury. Optic nerve crush (ONC), a well-validated… read more here.
Keywords: ganglion; retinal ganglion; traumatic optic; boxa ... See more keywords