Frenolicin B Targets Peroxiredoxin 1 and Glutaredoxin 3 to Trigger ROS/4E-BP1-Mediated Antitumor Effects.
Sign Up to like & getrecommendations! Published in 2019 at "Cell chemical biology"
DOI: 10.1016/j.chembiol.2018.11.013
Abstract: Peroxiredoxin 1 (Prx1) and glutaredoxin 3 (Grx3) are two major antioxidant proteins that play a critical role in maintaining redox homeostasis for tumor progression. Here, we identify the prototypical pyranonaphthoquinone natural product frenolicin B (FB)… read more here.
Keywords: bp1; glutaredoxin; prx1 grx3; frenolicin targets ... See more keywords
Occupancy of dopamine D2 and D3 receptors by a novel D3 partial agonist BP1.4979: a [11C]-(+)-PHNO PET study in humans
Sign Up to like & getrecommendations! Published in 2018 at "Neuropsychopharmacology"
DOI: 10.1038/s41386-018-0285-4
Abstract: There has been considerable interest in the development of dopamine D3 receptor (DRD3) partial agonists and antagonists for the treatment of substance use disorders. Pre-clinical evidence overwhelmingly supports the use of these drugs, but translation… read more here.
Keywords: novel partial; bp1; bp1 4979; agonist bp1 ... See more keywords
4E-BP1 counteracts human mesenchymal stem cell senescence via maintaining mitochondrial homeostasis
Sign Up to like & getrecommendations! Published in 2022 at "Protein & Cell"
DOI: 10.1093/procel/pwac037
Abstract: Abstract Although the mTOR-4E-BP1 signaling pathway is implicated in aging and aging-related disorders, the role of 4E-BP1 in regulating human stem cell homeostasis remains largely unknown. Here, we report that the expression of 4E-BP1 decreases… read more here.
Keywords: senescence; bp1; stem cell; cell senescence ... See more keywords
Abstract 5894: Snail reduces the antitumor efficacy of mTOR kinase inhibitors by transcriptional repression of 4E-BP1
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-5894
Abstract: The mTOR inhibitors, including the second generation of mTOR kinase inhibitors, for cancer treatment have been evaluated in clinical trials, but their overall activity as monotherapy is limited. The cap-dependent translation repressor, 4E-BP1, is an… read more here.
Keywords: kinase inhibitors; bp1; snail; mtor ... See more keywords
Abstract B41: BP1 is an important biomarker in breast cancer
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Cancer Research"
DOI: 10.1158/1557-3125.advbc17-b41
Abstract: Beta protein 1 (BP1), a transcription factor (TF) we identified and cloned, is encoded by a homeobox gene called DLX4. BP1 is overexpressed in breast cancer, prostate cancer, ovarian cancer, acute myeloid leukemia, non-small cell… read more here.
Keywords: bp1 important; bp1; breast cancer; important biomarker ... See more keywords
Mitotic CDK1 and 4E-BP1 I: Loss of 4E-BP1 serine 82 phosphorylation promotes proliferative polycystic disease and lymphoma in aged or sublethally irradiated mice
Sign Up to like & getrecommendations! Published in 2023 at "PLOS ONE"
DOI: 10.1371/journal.pone.0282722
Abstract: 4E-BP1 is a tumor suppressor regulating cap-dependent translation that is in turn controlled by mechanistic target of rapamycin (mTOR) or cyclin-dependent kinase 1 (CDK1) phosphorylation. 4E-BP1 serine 82 (S82) is phosphorylated by CDK1, but not… read more here.
Keywords: lymphoma; disease; mice; bp1 serine ... See more keywords
Mitotic CDK1 and 4E-BP1 II: A single phosphomimetic mutation in 4E-BP1 induces glucose intolerance in mice
Sign Up to like & getrecommendations! Published in 2023 at "PLOS ONE"
DOI: 10.1371/journal.pone.0282914
Abstract: Objective Cyclin-dependent kinase 1 (CDK1)/cyclin B1 phosphorylates many of the same substrates as mTORC1 (a key regulator of glucose metabolism), including the eukaryotic initiation factor 4E-binding protein 1 (4E-BP1). Only mitotic CDK1 phosphorylates 4E-BP1 at… read more here.
Keywords: glucose intolerance; cdk1; mice; bp1s82d ... See more keywords
IGFBP-1 Expression Promotes Tamoxifen Resistance in Breast Cancer Cells via Erk Pathway Activation
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2020.00233
Abstract: Insulin-like growth factor (IGF) system plays a significant role in many cellular processes, including proliferation, and survival. In estrogen receptor positive breast cancer, the level of circulating IGF-1 is positively associated with the incidence and… read more here.
Keywords: breast; bp1; breast cancer; expression ... See more keywords
Increased phosphorylation of 4E‑binding protein 1 predicts poor prognosis for patients with colorectal cancer.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular medicine reports"
DOI: 10.3892/mmr.2017.6352
Abstract: As demonstrated in previous studies, the phosphorylated form of 4E‑binding protein 1 (p‑4E‑BP1) may be a suitable tumor biomarker. The aim of the current study was to examine the expression status of p‑4E‑BP1 in colorectal… read more here.
Keywords: protein; colorectal cancer; bp1; expression ... See more keywords