Blastic plasmacytoid dendritic cell neoplasm (BPDCN): A promising future in the era of targeted therapeutics
Sign Up to like & getrecommendations! Published in 2022 at "Cancer"
DOI: 10.1002/cncr.34345
Abstract: Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematologic malignancy arising from precursor dendritic cells. BPDCN cells characteristically express several markers on their cell surfaces including CD123, CD4, and CD56. Because of its rarity… read more here.
Keywords: cell; dendritic cell; plasmacytoid dendritic; treatment ... See more keywords
Recurrent 8q24 rearrangement in blastic plasmacytoid dendritic cell neoplasm: association with immunoblastoid cytomorphology, MYC expression, and drug response
Sign Up to like & getrecommendations! Published in 2018 at "Leukemia"
DOI: 10.1038/s41375-018-0154-5
Abstract: Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare skin-tropic hematological malignancy of uncertain pathogenesis and poor prognosis. We examined 118 BPDCN cases for cytomorphology, MYC locus rearrangement, and MYC expression. Sixty-two (53%) and 41… read more here.
Keywords: immunoblastoid cytomorphology; myc bpdcn; expression; bpdcn ... See more keywords
Evaluating tagraxofusp for the treatment of blastic plasmacytoid dendritic cell neoplasm (BPDCN)
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Pharmacotherapy"
DOI: 10.1080/14656566.2022.2029846
Abstract: ABSTRACT Introduction Unique among hematologic malignancies, blastic plasmacytoid dendritic cell neoplasm (BPDCN) affects multiple compartments including bone marrow, hematologic, lymphatic, dermatologic, and central nervous systems (CNS). Treating BPDCN is challenging, historically, as patients display refractoriness… read more here.
Keywords: treatment; dendritic cell; blastic plasmacytoid; cell ... See more keywords
Targeting CD123 in BPDCN: an emerging field.
Sign Up to like & getrecommendations! Published in 2021 at "Expert review of hematology"
DOI: 10.1080/17474086.2021.1988848
Abstract: INTRODUCTION : Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive hematologic malignancy with historically poor outcomes for patients, often refractory to traditional chemotherapy. Recent research has focused on targeted therapy to improve… read more here.
Keywords: emerging field; bpdcn emerging; treatment; targeting cd123 ... See more keywords
Expanding the Immunophenotypic Spectrum of Neoplastic and Reactive Plasmacytoid Dendritic Cells.
Sign Up to like & getrecommendations! Published in 2023 at "American journal of clinical pathology"
DOI: 10.1093/ajcp/aqac174
Abstract: OBJECTIVES Targeted therapies for blastic plasmacytoid dendritic cell neoplasm (BPDCN) have presented a diagnostic dilemma for differentiating residual BPDCN from reactive plasmacytoid dendritic cells (pDCs) because these conditions have a similar immunoprofile, necessitating discovery of… read more here.
Keywords: reactive plasmacytoid; sox4; plasmacytoid dendritic; dendritic cells ... See more keywords
Blastic Plasmacytoid Dendritic Cell Neoplasm: Underlining the importance of an early diagnosis and the use of tagraxofusp therapy before wide dissemination
Sign Up to like & getrecommendations! Published in 2020 at "Australasian Journal of Dermatology"
DOI: 10.1111/ajd.13399
Abstract: A 63-year old man presented in May 2019; for 3 weeks, he complained of a slowly enlarging asymptomatic lesion on his left chest. On examination, he was found to have a single 12 9 8… read more here.
Keywords: diagnosis; blastic plasmacytoid; plasmacytoid dendritic; bpdcn ... See more keywords
Chronic myelomonocytic leukaemia followed by blastic plasmacytoid dendritic cell neoplasm
Sign Up to like & getrecommendations! Published in 2019 at "British Journal of Haematology"
DOI: 10.1111/bjh.15794
Abstract: A 74-year-old patient was hospitalised for the investigation of generalised lymphadenopathy and cutaneous manifestations (red and inflammatory nodules, erythema in 12 different localizations) 2 years after a diagnosis of chronic myelomonocytic leukaemia (CMML)-1 with a… read more here.
Keywords: blastic plasmacytoid; plasmacytoid dendritic; myelomonocytic leukaemia; bpdcn ... See more keywords
Blastic Plasmacytoid Dendritic Cell Neoplasm Is Dependent on BCL2 and Sensitive to Venetoclax.
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DOI: 10.1158/2159-8290.cd-16-0999
Abstract: Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is an aggressive hematologic malignancy with dismal outcomes for which no standard therapy exists. We found that primary BPDCN cells were dependent on the antiapoptotic protein BCL2 and were… read more here.
Keywords: venetoclax; blastic plasmacytoid; plasmacytoid dendritic; bpdcn ... See more keywords
Efficacy Proof of Concept for Allogeneic CD123 Targeting CAR T-Cells Against Primary Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN): Efficient Control of Tumor Progression in PDX Model and Potential Loss of CD123 Expression in Relapsed Disease
Sign Up to like & getrecommendations! Published in 2019 at "Blood"
DOI: 10.1182/blood-2019-126869
Abstract: Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare, aggressive hematologic malignancy with historically poor outcomes and no established standard of care. Nearly 100% of patients with BPDCN overexpress CD123, and targeting CD123 has therefore… read more here.
Keywords: research; cd123; bpdcn; research funding ... See more keywords
Anti-CD38 Monoclonal Antibody Daratuzumab Improve Responses to Chemotherapy-Refractory Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN): A Case Report
Sign Up to like & getrecommendations! Published in 2020 at "Blood"
DOI: 10.1182/blood-2020-143390
Abstract: Background Blastic plasmacytoid dendritic cell neoplasm (BPDCN) accounts for 0.44% of hematologic malignancies and is a rare aggressive myeloid neoplasm which shows high rates of cutaneous lesions, bone marrow involvement and lymphadenectasis. Central nervous system… read more here.
Keywords: treatment; case; blastic plasmacytoid; bpdcn ... See more keywords
sQuiz your knowledge! A strange keloid on the ear
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Dermatology"
DOI: 10.1684/ejd.2022.4372
Abstract: BPDCN is a rare haematological neoplasm with a poor prognosis [1]. The aetiology is unknown [2]. Although it usually appears de novo, an association with myeloid leukaemia and myelodysplastic syndrome has been reported [2]. Cutaneous… read more here.
Keywords: knowledge strange; keloid ear; diagnosis; strange keloid ... See more keywords