The relationship between the dopaminergic system and depressive symptoms in cervical dystonia
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Nuclear Medicine and Molecular Imaging"
DOI: 10.1007/s00259-017-3664-x
Abstract: PurposeCervical dystonia (CD) is associated with tremor/jerks (50%) and psychiatric complaints (17–70%). The dopaminergic system has been implicated in the pathophysiology of CD in animal and imaging studies. Dopamine may be related to the motor… read more here.
Keywords: system; dopaminergic system; bpnd; dystonia ... See more keywords
Amphetamine-Induced Striatal Dopamine Release Measured With an Agonist Radiotracer in Schizophrenia
Sign Up to like & getrecommendations! Published in 2018 at "Biological Psychiatry"
DOI: 10.1016/j.biopsych.2017.11.032
Abstract: BACKGROUND Receptor imaging studies have reported increased amphetamine-induced dopamine release in subjects with schizophrenia (SCH) relative to healthy control subjects (HCs). A limitation of these studies, performed with D2/3 antagonist radiotracers, is the failure to… read more here.
Keywords: bpnd; 11c npa; amphetamine induced; dopamine release ... See more keywords
Striatal phosphodiesterase 10A and medial prefrontal cortical thickness in patients with schizophrenia: a PET and MRI study
Sign Up to like & getrecommendations! Published in 2017 at "Translational Psychiatry"
DOI: 10.1038/tp.2017.11
Abstract: The enzyme phosphodiesterase 10A (PDE10A) is abundant in striatal medium spiny neurons and has been implicated in the pathophysiology of schizophrenia in animal models and is investigated as a possible new pharmacological treatment target. A… read more here.
Keywords: patients schizophrenia; bpnd; phosphodiesterase 10a; cortical thickness ... See more keywords
Positron Emission Tomography Assessments of Phosphodiesterase 10A in Patients With Schizophrenia
Sign Up to like & getrecommendations! Published in 2022 at "Schizophrenia Bulletin"
DOI: 10.1093/schbul/sbac181
Abstract: Abstract Background and hypothesis Phosphodiesterase 10A (PDE10A) is a highly expressed enzyme in the basal ganglia, where cortical glutamatergic and midbrain dopaminergic inputs are integrated. Therapeutic PDE10A inhibition effects on schizophrenia have been reported previously,… read more here.
Keywords: phosphodiesterase 10a; positron emission; patients schizophrenia; bpnd ... See more keywords
F144. MUSCARINIC M1 RECEPTOR SIGNALLING UNDERLYING COGNITION IN PSYCHOTIC DISORDERS
Sign Up to like & getrecommendations! Published in 2018 at "Schizophrenia Bulletin"
DOI: 10.1093/schbul/sby017.675
Abstract: Abstract Background Antipsychotic treatment has failed to improve cognitive deficits associated with psychotic disorders. This has led to an increased interest to revisit earlier implications from post-mortem studies that lowered muscarinic M1 receptor signaling may… read more here.
Keywords: bpnd; muscarinic receptor; activation; receptor ... See more keywords
Dopamine D2/D3 imbalance during migraine attack and allodynia in vivo
Sign Up to like & getrecommendations! Published in 2017 at "Neurology"
DOI: 10.1212/wnl.0000000000003861
Abstract: Objective: To evaluate in vivo the dynamics of endogenous dopamine (DA) neurotransmission during migraine ictus with allodynia. Methods: We examined 8 episodic migraineurs and 8 healthy controls (HC) using PET with [11C]raclopride. The uptake measure… read more here.
Keywords: attack; migraine; bpnd; 11c raclopride ... See more keywords
Assessing Amyloid Pathology in Cognitively Normal Subjects Using 18F-Flutemetamol PET: Comparing Visual Reads and Quantitative Methods
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Nuclear Medicine"
DOI: 10.2967/jnumed.118.211532
Abstract: Our objective was to determine the optimal approach for assessing amyloid disease in a cognitively normal elderly population. Methods: Dynamic 18F-flutemetamol PET scans were acquired using a coffee-break protocol (a 0- to 30-min scan and… read more here.
Keywords: bpnd; cognitively normal; pathology; 18f flutemetamol ... See more keywords
Serotonin Transporter Binding in the Human Brain After Pharmacological Challenge Measured Using PET and PET/MR
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2019.00172
Abstract: Introduction: In-vivo quantification of the serotonin transporter (SERT) guided our understanding of many neuropsychiatric disorders. A recently introduced bolus plus constant infusion protocol has been shown to allow the reliable determination of SERT binding with… read more here.
Keywords: serotonin transporter; pet; bpnd; pet scans ... See more keywords