Patterns of brachyury expression in chordomas.
Sign Up to like & getrecommendations! Published in 2021 at "Annals of diagnostic pathology"
DOI: 10.1016/j.anndiagpath.2021.151760
Abstract: INTRODUCTION Chordomas are rare malignant midline tumors, presumed to arise from notochordal remnants. This was further suggested by the discovery of the brachyury in chordomas pathogenesis. Its immunohistochemical expression has become the principal adjunct in… read more here.
Keywords: brachyury; brachyury expression; expression chordomas; expression ... See more keywords
Knockdown of Brachyury Suppresses Breast Cancer Cell Proliferation and Migration via Targeting E2F3
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Oncology"
DOI: 10.1155/2022/7913067
Abstract: Breast cancer is one of the most frequently diagnosed cancer in women and is the major cause of most cancer-related deaths. We previously reported that Brachyury, as a sensitive and specific marker, has been verified… read more here.
Keywords: breast cancer; proliferation migration; cancer; brachyury ... See more keywords
Abstract 1533: Transcriptional inhibition of brachyury in chordoma is associated with adoption of quiescent phenotype
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.am2017-1533
Abstract: BACKGROUND: Brachyury is a mesoderm specification transcription factor involved in notochord development and overexpressed in a variety of cancers, including chordoma. High levels of brachyury protein expression in cancers is associated with a poor prognosis… read more here.
Keywords: brachyury; quiescent phenotype; inhibition brachyury; expression ... See more keywords
A Preliminary Single-Cell RNA-Seq Analysis of Embryonic Cells That Express Brachyury in the Amphioxus, Branchiostoma japonicum
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DOI: 10.3389/fcell.2021.696875
Abstract: Among chordate taxa, the cephalochordates diverged earlier than urochordates and vertebrates; thus, they retain unique, primitive developmental features. In particular, the amphioxus notochord has muscle-like properties, a feature not seen in urochordates or vertebrates. Amphioxus… read more here.
Keywords: single cell; seq analysis; brachyury; expression ... See more keywords
The Role of Transcriptional Factor Brachyury on Cell Cycle Regulation in Non-small Cell Lung Cancer
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DOI: 10.3389/fonc.2020.01078
Abstract: Lung cancer is the leading cause of cancer-related death, and non-small cell lung cancer (NSCLC) accounts for almost 80–85% of all lung cancer cases. The transcriptional factor brachyury has been verified to promote tumor cells… read more here.
Keywords: cell; brachyury; cell cycle; lung cancer ... See more keywords
Clinicopathologic features of four rare types of chordomas, confirmed by brachyury immunostaining
Sign Up to like & getrecommendations! Published in 2017 at "Indian Journal of Pathology and Microbiology"
DOI: 10.4103/ijpm.ijpm_409_16
Abstract: Background: A wide clinicopathologic spectrum of a chordoma exists. Brachyury constitutes as its most useful diagnostic immunohistochemical (IHC) marker. Methods: During a 7-year-period, 4 unusual histopathologic types of chordomas were identified. Immunohistochemistry was performed by… read more here.
Keywords: year old; brachyury; types chordomas; chordomas ... See more keywords