Potent antiproliferative activity of bradykinin B2 receptor selective agonist FR-190997 and analogue structures thereof: A paradox resolved?
Sign Up to like & getrecommendations! Published in 2020 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2020.112948
Abstract: Βradykinin stimulation of B2 receptor is known to activate the oncogenic ERK pathway and overexpression of bradykinin receptors B1 and B2 has been reported to occur in glioma, colorectal and cervical cancers. B1R and B2R… read more here.
Keywords: agonist 190997; antiproliferative activity; receptor; bradykinin ... See more keywords
Bradykinin in asthma: Modulation of airway inflammation and remodelling
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2018.03.017
Abstract: Abstract Bradykinin, a pro‐inflammatory molecule, and its related peptides have been studied for their effects on acute reactions in upper and lower airways, where they can be synthesised and metabolized after exposure to different stimuli… read more here.
Keywords: asthma modulation; inflammation; bradykinin asthma; bradykinin ... See more keywords
Polyphenol-bradykinin interaction: Role in pain sensation
Sign Up to like & getrecommendations! Published in 2021 at "Food bioscience"
DOI: 10.1016/j.fbio.2021.100935
Abstract: Abstract It can be deduced from this concise review that bradykinin and polyphenols could have a double role in health. Nevertheless, if their bioavailability is improved by their encapsulation, polyphenols could diminish the binding affinity… read more here.
Keywords: pain sensation; bradykinin; role pain;
Panicolytic-like action of bradykinin in the dorsal periaqueductal gray through μ-opioid and B2-kinin receptors
Sign Up to like & getrecommendations! Published in 2017 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2017.05.025
Abstract: &NA; A wealth of evidence has shown that opioid and kinin systems may control proximal defense in the dorsal periaqueductal gray matter (dPAG), a critical panic‐associated area. Studies with drugs that interfere with serotonin–mediated neurotransmission… read more here.
Keywords: like effect; panicolytic like; receptor; bradykinin ... See more keywords
Bradykinin B1 receptor contributes to interleukin-8 production and glioblastoma migration through interaction of STAT3 and SP-1
Sign Up to like & getrecommendations! Published in 2019 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2018.10.033
Abstract: &NA; Glioblastoma (GBM), the most aggressive brain tumor, has a poor prognosis due to the ease of migration to surrounding healthy brain tissue. Recent studies have shown that bradykinin receptors are involved in the progression… read more here.
Keywords: glioblastoma; gbm; stat3; migration ... See more keywords
The anuran skin peptide bradykinin mediates its own absorption across epithelial barriers of the digestive tract
Sign Up to like & getrecommendations! Published in 2018 at "Peptides"
DOI: 10.1016/j.peptides.2018.03.010
Abstract: HighlightsSkin secreted bradykinin by frogs does not require absorption enhancing peptides for its uptake across epithelial barriers of the gut.Bradykinin increases the permeability of two cell models of the digestive tract at biologically relevant concentrations.This… read more here.
Keywords: absorption; peptide; across epithelial; epithelial barriers ... See more keywords
The desensitization of the transient receptor potential vanilloid 1 by nonpungent agonists and its resensitization by bradykinin
Sign Up to like & getrecommendations! Published in 2020 at "NeuroReport"
DOI: 10.1097/wnr.0000000000001485
Abstract: Transient receptor potential vanilloid type-1 (TRPV1) channels have crucial roles in inflammatory hyperalgesia. Different inflammatory mediators can modulate TRPV1 sensitization. Bradykinin is an algogenic substance released at the site of inflammation. The aim of the… read more here.
Keywords: bradykinin; trpv1; receptor; resensitization ... See more keywords
Bifunctional fusion proteins containing the sequence of the bradykinin homologue maximakinin: activities at the rat bradykinin B2 receptor.
Sign Up to like & getrecommendations! Published in 2018 at "Canadian journal of physiology and pharmacology"
DOI: 10.1139/cjpp-2017-0692
Abstract: To support bradykinin (BK) B2 receptor (B2R) detection and therapeutic stimulation, we developed and characterized fusion proteins consisting of the BK homolog maximakinin (MK), or variants, positioned at the C-terminus of functional proteins (enhanced green… read more here.
Keywords: fusion; microscopy; receptor; bradykinin ... See more keywords
Bradykinin and Galectin-3 in Survived and Deceased Patients with COVID-19 Pneumonia: An Increasingly Promising Biochemical Target
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/7920915
Abstract: Introduction There are still no definite curative or preventive strategies for COVID-19 disease. It is crucial to fully comprehend the pathogenesis of COVID-19 infection so that we can develop expedient pharmacological protocols. While the impact… read more here.
Keywords: covid pneumonia; deceased patients; bradykinin; bradykinin galectin ... See more keywords
A Mechanism for Hereditary Angioedema Caused by a Lysine311 to Glutamic Acid Substitution in Plasminogen.
Sign Up to like & getrecommendations! Published in 2022 at "Blood"
DOI: 10.1182/blood.2021012945
Abstract: Patients with hereditary angioedema (HAE) experience episodes of bradykinin-induced swelling of skin and mucosal membranes. The most common cause is reduced plasma activity of C1-inhibitor, the main regulator of the proteases plasma kallikrein (PKa) and… read more here.
Keywords: substitution; glu311; bradykinin; plasminogen ... See more keywords
Increased fibrinolysis-induced bradykinin formation in hereditary angioedema confirmed using stored plasma and biotechnological inhibitors
Sign Up to like & getrecommendations! Published in 2019 at "BMC Research Notes"
DOI: 10.1186/s13104-019-4335-8
Abstract: ObjectiveWe recently investigated the pathways of immunoreactive bradykinin (iBK) formation in fresh blood of normal volunteers and of patients with hereditary angioedema due to C1-esterase inhibitor deficiency (HAE-1/-2). Herein, we adapted the techniques to small… read more here.
Keywords: biotechnological inhibitors; plasma; formation; hereditary angioedema ... See more keywords