Early Increased Bradykinin 1 Receptor Contributes to Hemorrhagic Transformation After Ischemic Stroke in Type 1 Diabetic Rats
Sign Up to like & getrecommendations! Published in 2017 at "Translational Stroke Research"
DOI: 10.1007/s12975-017-0552-4
Abstract: Hemorrhagic transformation (HT) is a major complication of ischemic stroke and further deteriorates neurological outcomes. Bradykinin 1 receptor (B1R) has been proven to mediate vasculo-toxicity in various experimental models. However, its role in the development… read more here.
Keywords: ischemic stroke; bradykinin receptor; type; b1r ... See more keywords
Raf kinase inhibitory protein reduces bradykinin receptor desensitization
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neurochemistry"
DOI: 10.1111/jnc.15614
Abstract: Inflammatory hyperalgesia represents a nociceptive phenotype that can become persistent in nature through dynamic protein modifications. However, a large gap in knowledge exists concerning how the integration of intracellular signaling molecules coordinates a persistent inflammatory… read more here.
Keywords: desensitization; bradykinin receptor; receptor desensitization; raf kinase ... See more keywords
Influence of bradykinin B2 receptor and dopamine D2 receptor on the oxidative stress, inflammatory response, and apoptotic process in human endothelial cells
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DOI: 10.1371/journal.pone.0206443
Abstract: Endothelial dysfunction is a hallmark of a wide range of cardiovascular diseases and is often linked to oxidative stress and inflammation. Our earlier study reported the formation of a functional heterodimer between bradykinin receptor 2… read more here.
Keywords: bradykinin receptor; dopamine receptor; endothelial cells; receptor ... See more keywords
In Vitro Pharmacological Profile of a New Small Molecule Bradykinin B2 Receptor Antagonist
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2020.00916
Abstract: We here report the discovery and early characterization of Compound 3, a representative of a novel class of small molecule bradykinin (BK) B2 receptor antagonists, and its superior profile to the prior art B2 receptor… read more here.
Keywords: bradykinin receptor; compound compound; compound; receptor ... See more keywords