Identification of BRaf-Sparing Amino-Thienopyrimidines with Potent IRE1α Inhibitory Activity.
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DOI: 10.1021/acsmedchemlett.0c00344
Abstract: Amino-quinazoline BRaf kinase inhibitor 2 was identified from a library screen as a modest inhibitor of the unfolded protein response (UPR) regulating potential anticancer target IRE1α. A combination of crystallographic and conformational considerations were used… read more here.
Keywords: amino; braf activity; braf; identification braf ... See more keywords