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   Articles with "braf alterations" as a keyword



Classifying BRAF alterations in cancer: new rational therapeutic strategies for actionable mutations

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recommendations! Published in 2018 at "Oncogene"

DOI: 10.1038/s41388-018-0171-x

Abstract: The RAS–RAF–MEK–ERK signaling cascade is among the most frequently mutated pathways in human cancer. Approximately 50% of melanoma patients possess a druggable hotspot V600E/K mutation in the BRAF protein kinase. FDA-approved combination therapies of BRAF… read more here.

Keywords: braf alterations; braf; cancer; non v600 ... See more keywords

LGG-51. BRAF ALTERATIONS IN PEDIATRIC LOW-GRADE GLIOMAS: RESULTS FROM A BRAZILIAN COHORT

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recommendations! Published in 2020 at "Neuro-Oncology"

DOI: 10.1093/neuonc/noaa222.429

Abstract: Abstract BACKGROUND Pediatric low grade gliomas (PLGG) are the most common central nervous system neoplasms in children. These are driven almost exclusively by alterations in the RAS/MAPK pathway. Specifically, alterations in the BRAF gene have… read more here.

Keywords: braf alterations; brazilian cohort; braf; pediatric low ... See more keywords

PATH-34. Assessment of BRAF alterations and recommended treatments in CNS tumors with BRAF alterations

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recommendations! Published in 2025 at "Neuro-Oncology"

DOI: 10.1093/neuonc/noaf201.0986

Abstract: Comprehensive genomic profiling (CGP) has been reimbursed in Japan since June 2019, enabling treatment decisions based on genetic alterations. However, only 10–15% of patients receive genomically matched therapy, and its clinical utility remains limited. Our… read more here.

Keywords: cns tumors; treatment; recommended therapy; braf alterations ... See more keywords

Genomic Landscape, Clinical Features and Outcomes of Non-Small Cell Lung Cancer Patients Harboring BRAF Alterations of Distinct Functional Classes

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recommendations! Published in 2022 at "Cancers"

DOI: 10.3390/cancers14143472

Abstract: Simple Summary Non-small cell lung cancer (NSCLC) patients harboring BRAF non-V600 alterations constitute a heterogeneous and poorly studied population orphan of targeted therapies. We conducted a systematic review to detect all BRAF alterations of defined… read more here.

Keywords: cancer; braf alterations; nsclc patients; class ... See more keywords