An optimized workflow to improve reliability of detection of KIAA1549:BRAF fusions from RNA sequencing data
Sign Up to like & getrecommendations! Published in 2020 at "Acta Neuropathologica"
DOI: 10.1007/s00401-020-02167-1
Abstract: The KIAA1549:BRAF fusion is the most common alteration in pilocytic astrocytoma (PA). It is generated by a focal tandem duplication at 7q34 and acts as an oncogene by driving the mitogen-activated protein kinase (MAPK) pathway… read more here.
Keywords: detection; braf fusion; rna sequencing; kiaa1549 braf ... See more keywords
Pilocytic astrocytoma vs. ganglioglioma: Progression vs. misdiagnosis, and implications in BRAF testing
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Neuroscience"
DOI: 10.1016/j.jocn.2019.05.002
Abstract: Ganglioglioma (GG) is a mixed glio-neuronal tumour, comprised of a neoplastic glial component and dysplastic ganglion cells. GG is a tumour of unclear histogenesis; previous studies examining BRAF mutations and chromosome imprinting has provided evidence… read more here.
Keywords: pilocytic astrocytoma; braf; braf fusion; ganglioglioma ... See more keywords
Clinical relevance of BRAF status in glial and glioneuronal tumors: A systematic review
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Neuroscience"
DOI: 10.1016/j.jocn.2019.05.014
Abstract: Alterations in the BRAF gene have been reported to play a key role in the tumorigenesis of various tumors. Recent studies have shown the existence of BRAF alterations in ganglioglioma (GG), pilocytic astrocytoma (PA), pleomorphic… read more here.
Keywords: braf; braf fusion; review; glial glioneuronal ... See more keywords
Oncogenic BRAF fusions in mucosal melanomas activate the MAPK pathway and are sensitive to MEK/PI3K inhibition or MEK/CDK4/6 inhibition
Sign Up to like & getrecommendations! Published in 2017 at "Oncogene"
DOI: 10.1038/onc.2016.486
Abstract: Despite remarkable progress in cutaneous melanoma genomic profiling, the mutational landscape of primary mucosal melanomas (PMM) remains unclear. Forty-six PMMs underwent targeted exome sequencing of 111 cancer-associated genes. Seventy-six somatic nonsynonymous mutations in 42 genes… read more here.
Keywords: inhibition; braf; braf fusion; mucosal melanomas ... See more keywords
Identification and characterization of a BRAF fusion oncoprotein with retained autoinhibitory domains
Sign Up to like & getrecommendations! Published in 2019 at "Oncogene"
DOI: 10.1038/s41388-019-1021-1
Abstract: Fusion proteins involving the BRAF serine/threonine kinase occur in many cancers. The oncogenic potential of BRAF fusions has been attributed to the loss of critical N-terminal domains that mediate BRAF autoinhibition. We used whole-exome and… read more here.
Keywords: braf; fusion protein; braf fusion; fusion ... See more keywords
LGG-08. MR Imaging of pediatric low-grade gliomas: Pretherapeutic differentiation ofBRAF V600E mutation,BRAF-Fused and Wild-Type tumors in patients without Neurofibromatosis-1
Sign Up to like & getrecommendations! Published in 2022 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noac079.324
Abstract: Abstract OBJECTIVE: The prognosis and treatment of pediatric low-grade gliomas (pLGGs) is influenced by their molecular subtype. MRI remains the mainstay for initial work-up and surgical planning. We aimed to determine the relationship between imaging… read more here.
Keywords: braf v600e; braf; braf fusion; wild type ... See more keywords
PATH-56. PYROSEQUENCING METHOD FOR RAPID DETECTION OF KIAA1549-BRAF FUSION GENES IN PEDIATRIC BRAIN TUMORS
Sign Up to like & getrecommendations! Published in 2019 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noz175.651
Abstract: Fusion genes driving tumorigenesis have drawn the attention of oncologists and researchers. Recently, independent genomic researchers have identified a tandem duplication of BRAF at 7q34 that leads to several KIAA1549-BRAF gene exon fusions in the… read more here.
Keywords: braf; braf fusion; fusion genes; fusion ... See more keywords
A novel, potentially targetable TMEM106B-BRAF fusion in pleomorphic xanthoastrocytoma
Sign Up to like & getrecommendations! Published in 2017 at "Cold Spring Harbor Molecular Case Studies"
DOI: 10.1101/mcs.a001396
Abstract: Pleomorphic xanthoastrocytoma (PXA) is a World Health Organization (WHO) Grade II glioma occurring primarily in children and young adults. Most PXAs harbor the known activating mutation BRAF V600E. We report a case of locally recurrent… read more here.
Keywords: tmem106b braf; braf; braf fusion; pleomorphic xanthoastrocytoma ... See more keywords
Novel GLCCI1-BRAF fusion drives kinase signaling in a case of pheochromocytomatosis.
Sign Up to like & getrecommendations! Published in 2022 at "European journal of endocrinology"
DOI: 10.1530/eje-21-0797
Abstract: Introduction Recurrent and metastatic pheochromocytoma (PCC) are rare advanced endocrine neoplasms with limited treatment options. Insight into the pathogenic molecular alterations in patients with advanced PCC can provide therapeutic options for precisely targeting dysregulated pathways.… read more here.
Keywords: fusion; braf; pcc; pheochromocytomatosis ... See more keywords