Genetic Heterogeneity of BRAF Fusion Kinases in Melanoma Affects Drug Responses.
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2019.09.009
Abstract: BRAF fusions are detected in numerous neoplasms, but their clinical management remains unresolved. We identified six melanoma lines harboring BRAF fusions representative of the clinical cases reported in the literature. Their unexpected heterogeneous responses to… read more here.
Keywords: genetic heterogeneity; braf fusions; braf; fusion kinases ... See more keywords
Diverse BRAF Gene Fusions Confer Resistance to EGFR-Targeted Therapy via Differential Modulation of BRAF Activity
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DOI: 10.1158/1541-7786.mcr-19-0529
Abstract: Fusion genes can be oncogenic drivers in a variety of cancer types and represent potential targets for targeted therapy. The BRAF gene is frequently involved in oncogenic gene fusions, with fusion frequencies of 0.2%–3% throughout… read more here.
Keywords: therapy; braf fusions; fusion; braf ... See more keywords