FGF primes angioblast formation by inducing ETV2 and LMO2 via FGFR1/BRAF/MEK/ERK
Sign Up to like & getrecommendations! Published in 2020 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-020-03630-8
Abstract: It is critical to specify a signal that directly drives the transition that occurs between cell states. However, such inferences are often confounded by indirect intercellular communications or secondary transcriptomic changes due to primary transcription… read more here.
Keywords: fgf; mek erk; braf mek; etv2 lmo2 ... See more keywords
Cardiac Effects of BRAF and MEK Inhibitors: Mechanisms and Clinical Management
Sign Up to like & getrecommendations! Published in 2022 at "Current Oncology Reports"
DOI: 10.1007/s11912-022-01205-3
Abstract: Purpose of Review The identification of BRAF mutation prompted the development of new class of targeted therapy for treating melanoma: BRAF inhibitors and MEK inhibitors. Cardiovascular events have been reported with these treatments and could… read more here.
Keywords: oncology; braf mek; mek inhibitors; management ... See more keywords
Sarcoidosis related to checkpoint and BRAF/MEK inhibitors in melanoma.
Sign Up to like & getrecommendations! Published in 2020 at "Autoimmunity reviews"
DOI: 10.1016/j.autrev.2020.102587
Abstract: Therapy for advanced melanoma has deeply changed in the last decade with the introduction of checkpoint and BRAF/MEK inhibitors. Granulomatous reactions have been reported related to these drugs. We performed a systematic review of all… read more here.
Keywords: braf mek; checkpoint braf; mek inhibitors; sarcoidosis ... See more keywords
Clinical implications of ALDH1A1 and ALDH1A3 mRNA expression in melanoma subtypes.
Sign Up to like & getrecommendations! Published in 2019 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2019.108822
Abstract: Aldehyde dehydrogenase (ALDH) activity is not only a valuable marker for cancer cells with stem-like features, but also plays a vital role in drug resistance and disease progression in many tumors including melanoma. However, the… read more here.
Keywords: melanoma; braf mek; mek inhibitor; expression ... See more keywords
An Acquired Vulnerability of Drug-Resistant Melanoma with Therapeutic Potential
Sign Up to like & getrecommendations! Published in 2018 at "Cell"
DOI: 10.1016/j.cell.2018.04.012
Abstract: BRAF(V600E) mutant melanomas treated with inhibitors of the BRAF and MEK kinases almost invariably develop resistance that is frequently caused by reactivation of the mitogen activated protein kinase (MAPK) pathway. To identify novel treatment options… read more here.
Keywords: inhibitor; braf mek; resistant melanoma; drug ... See more keywords
Recent developments and obstacles in the treatment of melanoma with BRAF and MEK inhibitors.
Sign Up to like & getrecommendations! Published in 2018 at "Critical reviews in oncology/hematology"
DOI: 10.1016/j.critrevonc.2018.03.005
Abstract: Metastatic melanoma is a least common form of cancer as it accounts only for 1% of all cancer cases. But, it is most deadly in nature and is haunting mankind for long emotionally as well… read more here.
Keywords: melanoma; braf mek; mek inhibitors; mek ... See more keywords
The association between immune checkpoint or BRAF/MEK inhibitor therapy and uveitis in patients with advanced cutaneous melanoma.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of cancer"
DOI: 10.1016/j.ejca.2020.11.027
Abstract: BACKGROUND Treatment with immune checkpoint and BRAF/MEK inhibitors has significantly improved the survival of patients with advanced cutaneous melanoma and other metastatic malignancies. Therapy-related uveitis is a rare ocular adverse event, which may potentially lead… read more here.
Keywords: immune checkpoint; braf mek; checkpoint braf;
BRAF/MEK inhibitor-induced remission of primary cutaneous myoepithelial carcinoma after local recurrence
Sign Up to like & getrecommendations! Published in 2020 at "JAAD Case Reports"
DOI: 10.1016/j.jdcr.2019.07.023
Abstract: MEC: myoepithelial carcinoma PET: positron emission tomography INTRODUCTION Cutaneous myoepithelial carcinoma (MEC), also referred to as malignant myoepithelial tumor of the skin, is an extraordinarily rare diagnosis, with fewer than 15 cases reported in the… read more here.
Keywords: myoepithelial carcinoma; local recurrence; braf mek; cutaneous myoepithelial ... See more keywords
Sequential treatment failures in response to BRAF/MEK and immune checkpoint inhibitors mediated by MAP2K2 and B2M mutations in melanoma.
Sign Up to like & getrecommendations! Published in 2019 at "Experimental and molecular pathology"
DOI: 10.1016/j.yexmp.2019.104260
Abstract: Although the treatment of metastatic melanoma has been significantly improved by both anti-BRAF/MEK and checkpoint immunotherapies, resistance to these treatment modalities remains a substantial clinical problem. Multiple clinical studies are addressing the optimal sequencing of… read more here.
Keywords: treatment; map2k2 b2m; braf mek; checkpoint ... See more keywords
Atezolizumab plus cobimetinib and vemurafenib in BRAF-mutated melanoma patients
Sign Up to like & getrecommendations! Published in 2019 at "Nature Medicine"
DOI: 10.1038/s41591-019-0474-7
Abstract: Melanoma treatment has progressed in the past decade with the development and approval of immune checkpoint inhibitors targeting programmed death 1 (PD-1) or its ligand (PD-L1) and cytotoxic T lymphocyte-associated antigen 4, as well as… read more here.
Keywords: cobimetinib vemurafenib; braf mek; vemurafenib braf; braf ... See more keywords
Combined BRAF and MEK inhibition with PD-1 blockade immunotherapy in BRAF-mutant melanoma
Sign Up to like & getrecommendations! Published in 2019 at "Nature Medicine"
DOI: 10.1038/s41591-019-0476-5
Abstract: Oncogene-targeted therapy with B-Raf proto-oncogene (BRAF) and mitogen-activated protein kinase kinase (MEK) inhibitors induces a high initial response rate in patients with BRAFV600-mutated melanoma, with a median duration of response of approximately 1 year1–3. Immunotherapy… read more here.
Keywords: melanoma; braf mek; mek; response ... See more keywords