The stability of R-spine defines RAF inhibitor resistance: A comprehensive analysis of oncogenic BRAF mutants with in-frame insertion of αC-β4 loop
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DOI: 10.1126/sciadv.abg0390
Abstract: The stabilized R-spine of oncogenic BRAF mutants impairs RAF inhibitor association and confers drug resistance. Although targeting BRAF mutants with RAF inhibitors has achieved promising outcomes in cancer therapy, drug resistance remains a remarkable challenge,… read more here.
Keywords: braf mutants; braf; oncogenic braf; resistance ... See more keywords
Abstract 4078: Tumors with class 3 BRAF mutants are sensitive to the inhibition of activated RAS
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DOI: 10.1158/1538-7445.am2017-4078
Abstract: Approximately two hundred mutant BRAF alleles have been identified in human tumors. Physiologic activation of RAF isoforms requires RAS-dependent induction of their dimerization. Activating BRAF mutants cause ERK dependent feedback inhibition of RAS.GTP and are… read more here.
Keywords: braf mutants; class braf; mutants sensitive; braf ... See more keywords