First line treatment of BRAF mutated advanced melanoma: Does one size fit all?
Sign Up to like & getrecommendations! Published in 2021 at "Cancer treatment reviews"
DOI: 10.1016/j.ctrv.2021.102253
Abstract: In the last decade, immunotherapy and target therapy have revolutionized the prognosis of patients with BRAF-V600 mutation-positive metastatic melanoma. To date, three different combinations of BRAF/MEK inhibitors have been approved for this population, showing comparable… read more here.
Keywords: melanoma; first line; braf mutated; treatment ... See more keywords
Investigation of patterns of nodal metastases in BRAF mutant lung cancer.
Sign Up to like & getrecommendations! Published in 2017 at "Lung cancer"
DOI: 10.1016/j.lungcan.2017.02.024
Abstract: Axillary lymph nodes (axLN) are a rare site of nodal metastases in patients with lung cancer. BRAF mutated lung cancer is a genetically distinct subtype that occurs in 2-5% of non-small cell lung carcinomas (NSCLC).… read more here.
Keywords: axln metastases; braf mutated; lung cancer; mutated nsclc ... See more keywords
PDE4D promotes FAK-mediated cell invasion in BRAF-mutated melanoma
Sign Up to like & getrecommendations! Published in 2017 at "Oncogene"
DOI: 10.1038/onc.2016.469
Abstract: The cyclic AMP (cAMP) signaling pathway is critical in melanocyte biology for regulating differentiation. It is downregulated by phosphodiesterase (PDE) enzymes, which degrade cAMP itself. In melanoma evidence suggests that inhibition of the cAMP pathway… read more here.
Keywords: invasion; braf mutated; cell invasion; pde4d ... See more keywords
Clinical and radiological response of BRAF inhibition and MEK inhibition in patients with brain metastases from BRAF-mutated melanoma
Sign Up to like & getrecommendations! Published in 2018 at "Melanoma Research"
DOI: 10.1097/cmr.0000000000000429
Abstract: Patients with brain metastases (BM) from melanoma have an overall survival (OS) of 2–6 months after whole-brain radiotherapy. Targeted therapy (TT) is an effective treatment for BRAF-mutated metastatic melanoma. Moreover, recent studies indicate intracranial responses… read more here.
Keywords: patients brain; braf mutated; inhibition; mutated melanoma ... See more keywords
Complete response of brainstem metastasis in BRAF-mutated melanoma without stereotactic radiosurgery after initiation of encorafenib and binimetinib
Sign Up to like & getrecommendations! Published in 2021 at "Melanoma Research"
DOI: 10.1097/cmr.0000000000000750
Abstract: Metastatic melanoma is often accompanied by the development of brain metastases, at presentation or during the course of therapy. Local therapies such as surgery and radiation have been considered standard treatments for intracranial disease. However,… read more here.
Keywords: complete response; braf mutated; melanoma; mutated melanoma ... See more keywords
Two cases of BRAF‐mutated, bulbar conjunctival melanoma, and review of the published literature
Sign Up to like & getrecommendations! Published in 2019 at "Clinical and Experimental Dermatology"
DOI: 10.1111/ced.14060
Abstract: We describe two patients with BRAF‐mutated melanoma of the epithelioid cell type arising from primary acquired melanosis with severe atypia of the right bulbar conjunctiva. Patient 1 was a 71‐year‐old Japanese man. After adjuvant cryotherapy… read more here.
Keywords: bulbar; braf mutated; two cases; conjunctival melanoma ... See more keywords
Acral BRAF‐mutated tubular adenoma should be distinguished from HPV42‐related digital papillary adenocarcinoma
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Cutaneous Pathology"
DOI: 10.1111/cup.14430
Abstract: We read the article entitled “ Two distinct pathogenic pathways of digital papillary adenocarcinoma – BRAF mutation or low-risk HPV infection, ” which was recently published in your journal read more here.
Keywords: braf mutated; digital papillary; papillary adenocarcinoma; acral braf ... See more keywords
Single-Cell Profiling Reveals Metabolic Reprogramming as a Resistance Mechanism in BRAF-Mutated Multiple Myeloma
Sign Up to like & getrecommendations! Published in 2021 at "Clinical Cancer Research"
DOI: 10.1158/1078-0432.ccr-21-2040
Abstract: Purpose: Although remarkably effective in some patients, precision medicine typically induces only transient responses despite initial absence of resistance-conferring mutations. Using BRAF-mutated myeloma as a model for resistance to precision medicine we investigated if BRAF-mutated… read more here.
Keywords: medicine; braf; braf mutated; resistance ... See more keywords
The heterogeneous clinical and pathological landscapes of metastatic Braf-mutated colorectal cancer
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Cell International"
DOI: 10.1186/s12935-020-1117-2
Abstract: Colorectal cancer (CRC) is a complex and molecularly heterogeneous disease representing one of the most frequent causes of cancer-related death worldwide. About 8–15% of CRCs harbor a mutation in BRAF gene, a proto-oncogene involved in… read more here.
Keywords: braf mutated; colorectal cancer; braf; clinical pathological ... See more keywords
MicroRNA Expression in KRAS- and BRAF-mutated Colorectal Cancers.
Sign Up to like & getrecommendations! Published in 2018 at "Anticancer research"
DOI: 10.21873/anticanres.12272
Abstract: BACKGROUND/AIM KRAS and BRAF are two genes commonly mutated in colorectal cancer (CRC). Even though BRAF is a downstream target of KRAS in the MAPK signalling pathway, KRAS- and BRAF-mutated CRCs are found to display… read more here.
Keywords: kras braf; mir; braf mutated; mutated colorectal ... See more keywords
BRAF-Mutated Non-Small Cell Lung Cancer: Current Treatment Status and Future Perspective
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.863043
Abstract: V-Raf murine sarcoma viral oncogene homolog B (BRAF) kinase, which was encoded by BRAF gene, plays critical roles in cell signaling, growth, and survival. Mutations in BRAF gene will lead to cancer development and progression.… read more here.
Keywords: non small; braf; braf mutated; small cell ... See more keywords