First line treatment of BRAF mutated advanced melanoma: Does one size fit all?
Sign Up to like & getrecommendations! Published in 2021 at "Cancer treatment reviews"
DOI: 10.1016/j.ctrv.2021.102253
Abstract: In the last decade, immunotherapy and target therapy have revolutionized the prognosis of patients with BRAF-V600 mutation-positive metastatic melanoma. To date, three different combinations of BRAF/MEK inhibitors have been approved for this population, showing comparable… read more here.
Keywords: melanoma; first line; braf mutated; treatment ... See more keywords
Investigation of patterns of nodal metastases in BRAF mutant lung cancer.
Sign Up to like & getrecommendations! Published in 2017 at "Lung cancer"
DOI: 10.1016/j.lungcan.2017.02.024
Abstract: Axillary lymph nodes (axLN) are a rare site of nodal metastases in patients with lung cancer. BRAF mutated lung cancer is a genetically distinct subtype that occurs in 2-5% of non-small cell lung carcinomas (NSCLC).… read more here.
Keywords: axln metastases; braf mutated; lung cancer; mutated nsclc ... See more keywords
PDE4D promotes FAK-mediated cell invasion in BRAF-mutated melanoma
Sign Up to like & getrecommendations! Published in 2017 at "Oncogene"
DOI: 10.1038/onc.2016.469
Abstract: The cyclic AMP (cAMP) signaling pathway is critical in melanocyte biology for regulating differentiation. It is downregulated by phosphodiesterase (PDE) enzymes, which degrade cAMP itself. In melanoma evidence suggests that inhibition of the cAMP pathway… read more here.
Keywords: invasion; braf mutated; cell invasion; pde4d ... See more keywords
CPC13 BRAF mutated and morphologically Spitz naevi and tumours: a series of four cases
Sign Up to like & getrecommendations! Published in 2024 at "British Journal of Dermatology"
DOI: 10.1093/bjd/ljae090.026
Abstract: The current World Health Organization classification of skin tumours (5th edition) indicates that melanocytic tumours of the Spitz pathway can be defined by mutually exclusive oncogenic drivers, including HRAS-activating mutations or kinase fusions. Accordingly, the… read more here.
Keywords: braf; naevi tumours; braf mutated; mutated morphologically ... See more keywords
Clinical and radiological response of BRAF inhibition and MEK inhibition in patients with brain metastases from BRAF-mutated melanoma
Sign Up to like & getrecommendations! Published in 2018 at "Melanoma Research"
DOI: 10.1097/cmr.0000000000000429
Abstract: Patients with brain metastases (BM) from melanoma have an overall survival (OS) of 2–6 months after whole-brain radiotherapy. Targeted therapy (TT) is an effective treatment for BRAF-mutated metastatic melanoma. Moreover, recent studies indicate intracranial responses… read more here.
Keywords: patients brain; braf mutated; inhibition; mutated melanoma ... See more keywords
Complete response of brainstem metastasis in BRAF-mutated melanoma without stereotactic radiosurgery after initiation of encorafenib and binimetinib
Sign Up to like & getrecommendations! Published in 2021 at "Melanoma Research"
DOI: 10.1097/cmr.0000000000000750
Abstract: Metastatic melanoma is often accompanied by the development of brain metastases, at presentation or during the course of therapy. Local therapies such as surgery and radiation have been considered standard treatments for intracranial disease. However,… read more here.
Keywords: complete response; braf mutated; melanoma; mutated melanoma ... See more keywords
Tumor eradication by triplet therapy with BRAF inhibitor, TLR 7 agonist, and PD‐1 antibody for BRAF ‐mutated melanoma
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DOI: 10.1111/cas.16251
Abstract: Programmed death 1 (PD‐1)/programmed death‐ligand 1 inhibitors are commonly used to treat various cancers, including melanoma. However, their efficacy as monotherapy is limited, and combination immunotherapies are being explored to improve outcomes. In this study,… read more here.
Keywords: braf; braf inhibitor; braf mutated; cell ... See more keywords
Two cases of BRAF‐mutated, bulbar conjunctival melanoma, and review of the published literature
Sign Up to like & getrecommendations! Published in 2019 at "Clinical and Experimental Dermatology"
DOI: 10.1111/ced.14060
Abstract: We describe two patients with BRAF‐mutated melanoma of the epithelioid cell type arising from primary acquired melanosis with severe atypia of the right bulbar conjunctiva. Patient 1 was a 71‐year‐old Japanese man. After adjuvant cryotherapy… read more here.
Keywords: bulbar; braf mutated; two cases; conjunctival melanoma ... See more keywords
Acral BRAF‐mutated tubular adenoma should be distinguished from HPV42‐related digital papillary adenocarcinoma
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Cutaneous Pathology"
DOI: 10.1111/cup.14430
Abstract: We read the article entitled “ Two distinct pathogenic pathways of digital papillary adenocarcinoma – BRAF mutation or low-risk HPV infection, ” which was recently published in your journal read more here.
Keywords: braf mutated; digital papillary; papillary adenocarcinoma; acral braf ... See more keywords
Single-Cell Profiling Reveals Metabolic Reprogramming as a Resistance Mechanism in BRAF-Mutated Multiple Myeloma
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DOI: 10.1158/1078-0432.ccr-21-2040
Abstract: Purpose: Although remarkably effective in some patients, precision medicine typically induces only transient responses despite initial absence of resistance-conferring mutations. Using BRAF-mutated myeloma as a model for resistance to precision medicine we investigated if BRAF-mutated… read more here.
Keywords: medicine; braf; braf mutated; resistance ... See more keywords
Abstract 5052: Novel drug resistance mechanisms and drug targets in BRAF mutated peritoneal metastasis from colorectal cancer
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.am2024-5052
Abstract: Objective: Patients with peritoneal metastasis (PM) from colorectal cancer (CRC) have inferior prognosis and respond poorly to chemotherapy compared to other metastatic locations. This study aims to identify the molecular explanation for the observed clinical… read more here.
Keywords: colorectal cancer; cancer; braf mutated; drug ... See more keywords