Age‐dependent performance of BRAF mutation testing in Lynch syndrome diagnostics
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Cancer"
DOI: 10.1002/ijc.33273
Abstract: BRAF V600E mutations have been reported as a marker of sporadic microsatellite instability (MSI) colorectal cancer (CRC). Current international diagnostic guidelines recommend BRAF mutation testing in MSI CRC patients to predict low risk of Lynch… read more here.
Keywords: age; braf testing; braf; mutation testing ... See more keywords
Imaging predictors of BRAF mutation in colorectal cancer
Sign Up to like & getrecommendations! Published in 2020 at "Abdominal Radiology"
DOI: 10.1007/s00261-020-02484-9
Abstract: Background Colorectal cancer (CRC) is one of the leading causes of cancer deaths and is associated with various genetic mutations. BRAF mutations, found in approximately 10% of all CRCs, are associated with negative predictive outcomes.… read more here.
Keywords: colorectal cancer; imaging predictors; braf mutation; cancer ... See more keywords
BRAF mutation testing in melanoma: results from a German observational multicenter study
Sign Up to like & getrecommendations! Published in 2018 at "Virchows Archiv"
DOI: 10.1007/s00428-018-2480-4
Abstract: Quality control of BRAF mutation testing methods used in routine practice is crucial for optimal treatment selection. In this prospective study, we assessed the impact of patient/sample characteristics on BRAF mutation testing results in patients… read more here.
Keywords: sample; mutation testing; pathology; study ... See more keywords
Clinicopathologic features and BRAF mutation status of tracheal glomus tumors - Characterization of 4 cases and the distinction from low-grade neuroendocrine tumors.
Sign Up to like & getrecommendations! Published in 2021 at "Annals of diagnostic pathology"
DOI: 10.1016/j.anndiagpath.2021.151797
Abstract: BACKGROUND Glomus tumors are uncommon and mostly benign mesenchymal neoplasms of the perivascular family. To date, only a few cases of glomus tumors occurring in the trachea have been reported. Tracheal glomus tumors simulated low-grade… read more here.
Keywords: glomus; glomus tumors; tracheal glomus; braf mutation ... See more keywords
Radiogenomic evaluation of lung cancer - Are there imaging characteristics associated with lung adenocarcinomas harboring BRAF mutations?
Sign Up to like & getrecommendations! Published in 2017 at "Clinical imaging"
DOI: 10.1016/j.clinimag.2016.11.015
Abstract: INTRODUCTION We studied computed tomography (CT) features associated with BRAF mutated lung cancer. MATERIALS AND METHODS CT features of BRAF mutated lung cancers were compared to stage matched lesions without BRAF mutation. RESULTS 47 (25%)… read more here.
Keywords: braf lesions; braf; braf mutation; lung cancer ... See more keywords
Tumour infiltrating lymphocyte status is superior to histological grade, DNA mismatch repair and BRAF mutation for prognosis of colorectal adenocarcinomas with mucinous differentiation
Sign Up to like & getrecommendations! Published in 2020 at "Modern Pathology"
DOI: 10.1038/s41379-020-0496-1
Abstract: Mucinous colorectal adenocarcinoma (CRC) is conventionally defined by extracellular mucin comprising >50% of the tumour area, while tumours with ≤50% mucin are designated as having a mucinous component. However, these definitions are largely arbitrary and… read more here.
Keywords: status; braf mutation; grade; mucinous component ... See more keywords
Nuclear morphometric findings in undetermined cytology: A possible clue for prediction of BRAF mutation in papillary thyroid carcinomas
Sign Up to like & getrecommendations! Published in 2017 at "Endocrine Research"
DOI: 10.1080/07435800.2016.1255895
Abstract: ABSTRACT Purpose: To investigate the possible relationship between the nuclear morphometric characteristics (nuclear perimeter, roundness, nuclear area, and nuclear shape) and BRAF mutation status in papillary thyroid carcinoma cases with a prior diagnosis of undetermined… read more here.
Keywords: papillary thyroid; nuclear morphometric; braf mutation; cytology ... See more keywords
Rapid BRAF mutation tests in patients with advanced melanoma: comparison of immunohistochemistry, Droplet Digital PCR, and the Idylla Mutation Platform
Sign Up to like & getrecommendations! Published in 2018 at "Melanoma Research"
DOI: 10.1097/cmr.0000000000000421
Abstract: BRAF mutational testing has become a common practice in the diagnostic process of patients with advanced melanoma. Although time-consuming, DNA sequencing techniques are the current gold standard for mutational testing. However, in certain clinical situations,… read more here.
Keywords: mutation; droplet digital; idylla; braf mutation ... See more keywords
Demystifying BRAF Mutation Status in Colorectal Liver Metastases: A Multi-institutional, Collaborative Approach to 6 Open Clinical Questions.
Sign Up to like & getrecommendations! Published in 2022 at "Annals of surgery"
DOI: 10.1097/sla.0000000000005771
Abstract: OBJECTIVE To investigate the clinical implications of BRAF mutated (mutBRAF) colorectal liver metastases (CRLM). SUMMARY BACKGROUND DATA The clinical implications of mutBRAF status in CRLM are largely unknown. METHODS Patients undergoing resection for mutBRAF CRLM… read more here.
Keywords: braf mutation; disease; status; colorectal liver ... See more keywords
Comment on: BRAF mutation analysis by ARMS‐PCR refines thyroid nodule management
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Endocrinology"
DOI: 10.1111/cen.14103
Abstract: we read the paper by Li and colleagues1 , aiming to explore the clinical significance of the BRAF p.V600E mutation in a preoperative setting, as an aid to decision-making. In order to improve the pre-operative… read more here.
Keywords: arms pcr; analysis; comment braf; braf mutation ... See more keywords
Abstract 5375: OncogenicBRAFmutation induces widespread DNA hypermethylation in a murine model for human serrated colorectal neoplasia
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.am2017-5375
Abstract: BACKGROUND: The serrated colorectal neoplasia pathway describes the progression of morphologically serrated polyps to cancer and accounts for approximately one third of all colorectal cancer cases. Human serrated polyps are characterised by activating mutation of… read more here.
Keywords: human serrated; model; braf mutation; cancer ... See more keywords