Assessment of BRAF V600E (VE1) immunochemistry for the detection of BRAF V600E mutation in non–small cell lung carcinoma cytology specimens
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Cytopathology"
DOI: 10.1002/cncy.22648
Abstract: Non–small cell lung carcinoma (NSCLC) patients with BRAF V600E–mutated tumors respond to targeted therapy. Testing for BRAF V600E is commonly performed with molecular methods; however, a mutation‐specific VE1 antibody clone can provide an alternative testing… read more here.
Keywords: ve1; immunochemistry; braf v600e; cytology ... See more keywords
BRAF V600E and previously unidentified KRAS G12C mutations in odontogenic tumors may affect MAPK activation differently depending on tumor type
Sign Up to like & getrecommendations! Published in 2022 at "Genes"
DOI: 10.1002/gcc.23040
Abstract: Although several types of odontogenic tumors share the same mutations in MAPK pathway genes, their effects on MAPK activation remain unclarified. This study aimed to evaluate the associations between these mutations and ERK phosphorylation in… read more here.
Keywords: braf v600e; previously unidentified; ameloblastoma; mapk activation ... See more keywords
Molecular analysis of BRAF V600E mutation in multiple nodules of pulmonary Langerhans cell histiocytosis
Sign Up to like & getrecommendations! Published in 2017 at "Virchows Archiv"
DOI: 10.1007/s00428-017-2092-4
Abstract: Pulmonary Langerhans cell histiocytosis (PLCH) is a rare, smoking-related histiocytic disorder with variable clinical symptoms. Like in other non-pulmonary Langerhans cell proliferations, PLCH has recently been shown to harbour BRAF V600E mutations in a significant… read more here.
Keywords: langerhans cell; braf v600e; braf; pulmonary langerhans ... See more keywords
BRAFV600E, hypothyroidism, and human relaxin in thyroid carcinogenesis
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DOI: 10.1007/s00432-020-03401-9
Abstract: Purpose BRAF V600E , a major driver of thyroid cancer, evaluated in the context of thyroid hormones and human relaxin. Methods Immunohistochemical expressions of BRAF V600E , TSH, TSH receptor (TSHR), T4, T3 receptor (T3R),… read more here.
Keywords: braf v600e; tsh; thyroid carcinogenesis; thyroid ... See more keywords
Cost-Effectiveness Analysis of Encorafenib, Binimetinib, and Cetuximab in BRAF V600E-Mutated Metastatic Colorectal Cancer in the USA
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DOI: 10.1007/s12325-021-01627-8
Abstract: Recently the phase 3 BEACON trial showed that the combination of encorafenib, cetuximab, and binimetinib versus cetuximab and irinotecan/FOLFIRI improved overall survival in pre-treated patients with metastatic colorectal cancer (mCRC) with BRAF V600E mutation. However,… read more here.
Keywords: braf v600e; cetuximab; cost effectiveness; cost ... See more keywords
Relationships of BRAF mutation and HMGB1 to papillary thyroid carcinoma.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.03.117
Abstract: A poor papillary thyroid cancer (PTC) prognosis is strongly associated with the BRAF V600E mutation. During tumor progression, levels of the high mobility group box 1 (HMGB1) protein are often dysregulated. Results herein demonstrate that… read more here.
Keywords: hmgb1; braf v600e; papillary thyroid; ptc tissues ... See more keywords
TTF-1 positive posterior pituitary tumor: Limitations of current treatment and potential new hope in BRAF V600E mutation variants
Sign Up to like & getrecommendations! Published in 2020 at "Clinical Neurology and Neurosurgery"
DOI: 10.1016/j.clineuro.2020.106059
Abstract: Abstract Spindle cell oncocytoma (SCO) represents one of the four TTF-1 positive posterior pituitary tumors (PPTs) as defined by the World Health Organization in 2017. Due to the recurrent nature of these tumors, repeat interventions… read more here.
Keywords: braf v600e; braf; ttf positive; mutation ... See more keywords
Autophagy-related protein expression was associated with BRAF V600E mutation in epilepsy associated glioneuronal tumors
Sign Up to like & getrecommendations! Published in 2017 at "Epilepsy Research"
DOI: 10.1016/j.eplepsyres.2017.06.006
Abstract: PURPOSE The aim of this study was to explore the expression level of autophagy-related proteins in epileptic patients with glioneuronal tumors (GNTs) and evaluate the association with clinicopathological features. MATERIALS AND METHODS We obtained the… read more here.
Keywords: braf v600e; expression; v600e mutation; autophagy related ... See more keywords
Clinical significance of BRAF V600E mutational status in capsular nevi of sentinel lymph nodes in patients with primary cutaneous melanoma.
Sign Up to like & getrecommendations! Published in 2017 at "Human pathology"
DOI: 10.1016/j.humpath.2016.09.010
Abstract: Capsular nevi (CN) are clusters of benign melanocytes situated in the capsule of lymph nodes and occur in up to 20% of lympadenectomy specimens. The molecular profile of CN in relation to prognostic parameters in… read more here.
Keywords: braf v600e; braf; v600e mutation; lymph nodes ... See more keywords
Desmoplastic non-infantile astrocytoma/ganglioglioma: rare low-grade tumor with frequent BRAF V600E mutation.
Sign Up to like & getrecommendations! Published in 2018 at "Human pathology"
DOI: 10.1016/j.humpath.2018.06.005
Abstract: Desmoplastic infantile astrocytoma/ganglioglioma (DIA/DIG) are rare primary glioneuronal tumors that comprise 0.5% to 1.0% of all intracranial tumors. While BRAF mutation is found in up to 50% of pediatric gangliogliomas, data for DIA/DIGs is limited.… read more here.
Keywords: braf v600e; astrocytoma ganglioglioma; braf; v600e mutation ... See more keywords
Identification of the BRAF V600E mutation in a patient with sclerosing pneumocytoma: A case report.
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DOI: 10.1016/j.lungcan.2019.09.004
Abstract: OBJECTIVES Sclerosing pneumocytoma (sclerosing hemangioma, SP) is a rare benign tumor of the lung with a low risk of recurrence. The genomic profile of SP is not well-known. Here we report gene mutation findings in… read more here.
Keywords: braf v600e; sclerosing pneumocytoma; v600e mutation; mutation ... See more keywords