A phase 2 clinical trial on trametinib and low-dose dabrafenib in advanced pretreated BRAFV600/NRASQ61R/K/L wild-type melanoma (TraMel-WT): Interim efficacy and safety results.
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DOI: 10.1200/jco.2021.39.15_suppl.9529
Abstract: 9529 Background: The mitogen-activated protein kinase (MAPK) pathway can be activated by alternative driver mutations in BRAFV600/ NRASQ61R/K/L wild-type (wt) melanoma. MEK-inhibitor monotherapy has activity in BRAFV600/ NRASQ61R/K/L wt melanoma, but is associated with considerate… read more here.
Keywords: melanoma; brafv600 nrasq61r; trial; skin toxicity ... See more keywords