Analysis of the BRAFV600E mutation in 19 cases of Langerhans cell histiocytosis in Japan
Sign Up to like & getrecommendations! Published in 2017 at "Hematological Oncology"
DOI: 10.1002/hon.2293
Abstract: Langerhans cell histiocytosis (LCH) is a rare disease characterized by clonal proliferation of CD1a‐ and CD207 (langerin)‐positive dendritic cells. Mutated BRAF (p.V600E) is observed in histiocyte‐related diseases and dendritic cell‐related diseases, including LCH. BRAFV600E is… read more here.
Keywords: langerhans cell; analysis; brafv600e mutation; cell histiocytosis ... See more keywords
Contextual role of E2F1 in suppression of melanoma cell motility and invasiveness
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.23043
Abstract: The general transcription factor E2F1 reportedly functions in a protumorigenic manner in several cancer models. We show that the genetic context of cancer cells influence E2F1's role to impede the protumorigenic role. Thirty to fifty… read more here.
Keywords: melanoma; oncogenic braf; e2f1; brafv600e ... See more keywords
Mefloquine induces ER stress and apoptosis in BRAFi‐resistant A375‐BRAFV600E/NRASQ61K malignant melanoma cells targeting intracranial tumors in a bioluminescent murine model
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.23407
Abstract: Molecularly targeted therapeutics have revolutionized the treatment of BRAFV600E‐driven malignant melanoma, but the rapid development of resistance to BRAF kinase inhibitors (BRAFi) presents a significant obstacle. The use of clinical antimalarials for the investigational treatment… read more here.
Keywords: melanoma; brafv600e; brafv600e nrasq61k; a375 brafv600e ... See more keywords
Synthesis and biological evaluation of novel N-(5-phenyl-1H-pyrazol-3-yl)benzenesulfonamide derivatives as potential BRAFV600E inhibitors
Sign Up to like & getrecommendations! Published in 2017 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-017-1957-z
Abstract: A series of novel N-(5-phenyl-1H-pyrazol-3-yl)benzenesulfonamide derivatives (5a–5l) were synthesized and developed as potential BRAFV600E inhibitors. Among them, compound 5l exhibited the most potent inhibitory activity with an IC50 value of 0.18 μM for BRAFV600E. Antiproliferative assay… read more here.
Keywords: benzenesulfonamide derivatives; potential brafv600e; brafv600e; novel phenyl ... See more keywords
Marked functional recovery and imaging response of refractory optic pathway glioma to BRAFV600E inhibitor therapy: a report of two cases
Sign Up to like & getrecommendations! Published in 2018 at "Child's Nervous System"
DOI: 10.1007/s00381-018-3739-4
Abstract: BackgroundDespite appropriate therapeutic interventions, progressive optic pathway glioma (OPG) in children may result in loss of vision and other neurologic morbidities. Molecularly targeted therapy against the MAP kinase pathway holds promise in improving outcomes while… read more here.
Keywords: inhibitor; response; pathway glioma; pathway ... See more keywords
Dabrafenib in BRAFV600E mutant pilocytic astrocytoma
Sign Up to like & getrecommendations! Published in 2020 at "Child's Nervous System"
DOI: 10.1007/s00381-020-04527-4
Abstract: Dear Editor: We read the report on “Dabrafenib in BRAFV600E mutant pilocytic astrocytoma (PA) in a pediatric patient” with a great interest [1]. Mustansir et al. concluded that “We report a case of successful treatment… read more here.
Keywords: pilocytic astrocytoma; dabrafenib; mutant pilocytic; dabrafenib brafv600e ... See more keywords
Clinical significance of the BRAFV600E mutation in Asian patients with colorectal cancer
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Colorectal Disease"
DOI: 10.1007/s00384-018-3095-6
Abstract: BackgroundTo investigate the clinicopathological features and prognostic significance of the BRAFV600E mutation in Asian patients with colorectal cancer.MethodsWe retrospectively reviewed the medical records of 1969 patients with colorectal cancer admitted to Taipei Veterans General Hospital… read more here.
Keywords: patients colorectal; brafv600e mutation; colorectal cancer; brafv600e ... See more keywords
Immunohistochemistry as an accurate tool for evaluating BRAF‐V600E mutation in 130 samples of papillary thyroid cancer
Sign Up to like & getrecommendations! Published in 2017 at "Surgery"
DOI: 10.1016/j.surg.2016.06.081
Abstract: Background. BRAFV600E mutation has been investigated by immunohistochemistry and has shown high sensitivity and specificity. We aim to investigate the accuracy of immunohistochemistry versus molecular testing of BRAFV600E in papillary thyroid cancer using a large… read more here.
Keywords: papillary thyroid; immunohistochemistry; brafv600e; thyroid cancer ... See more keywords
Obstruction of BRAFV600E transcription by complementary PNA oligomers as a means to inhibit BRAF-mutant melanoma growth
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Gene Therapy"
DOI: 10.1038/cgt.2017.34
Abstract: Peptide nucleic acid (PNA) oligomers are DNA mimics, which are capable of binding gene sequences 1000-fold more avidly than complementary native DNA by strand invasion and effectively obstruct transcription. Irreversibly obstructing the transcription or replication… read more here.
Keywords: melanoma; transcription; pna; brafv600e ... See more keywords
BRAFV600E-induced senescence drives Langerhans cell histiocytosis pathophysiology.
Sign Up to like & getrecommendations! Published in 2021 at "Nature medicine"
DOI: 10.1038/s41591-021-01304-x
Abstract: Langerhans cell histiocytosis (LCH) is a potentially fatal condition characterized by granulomatous lesions with characteristic clonal mononuclear phagocytes (MNPs) harboring activating somatic mutations in mitogen-activated protein kinase (MAPK) pathway genes, most notably BRAFV600E. We recently… read more here.
Keywords: langerhans cell; senescence; cell histiocytosis; brafv600e ... See more keywords
Gaussian field-based 3D-QSAR and molecular simulation studies to design potent pyrimidine–sulfonamide hybrids as selective BRAFV600E inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "RSC Advances"
DOI: 10.1039/d2ra05751d
Abstract: The “RAS-RAF-MEK-ERK” pathway is an important signaling pathway in melanoma. BRAFV600E (70–90%) is the most common mutation in this pathway. BRAF inhibitors have four types of conformers: type I (αC-IN/DFG-IN), type II (αC-IN/DFG-OUT), type I1/2… read more here.
Keywords: brafv600e inhibitors; brafv600e; pyrimidine sulfonamide; dfg ... See more keywords