Purified oleocanthal and ligstroside protect against mitochondrial dysfunction in models of early Alzheimer's disease and brain ageing
Sign Up to like & getrecommendations! Published in 2020 at "Experimental Neurology"
DOI: 10.1016/j.expneurol.2020.113248
Abstract: As components of the Mediterranean diet (MedDiet) olive polyphenols may play a crucial role for the prevention of Alzheimer's disease (AD). Since mitochondrial dysfunction is involved in both, brain ageing and early AD, effects of… read more here.
Keywords: brain ageing; alzheimer disease; mitochondrial dysfunction; oleocanthal ligstroside ... See more keywords
Brain ageing: A youthful reminder
Sign Up to like & getrecommendations! Published in 2017 at "Nature Reviews Neuroscience"
DOI: 10.1038/nrn.2017.59
Abstract: A study shows that systemic adminstration of plasma from human umbilical cord counteracts ageing-induced impairment of hippocampal function in mice and identifies a key protein in plasma that confers such effects. read more here.
Keywords: brain ageing; youthful reminder; ageing youthful;
Accelerated brain ageing during the COVID-19 pandemic
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-61033-4
Abstract: The impact of SARS-CoV-2 and the COVID-19 pandemic on brain health is recognised, yet specific effects remain understudied. We investigate the pandemic’s impact on brain ageing using longitudinal neuroimaging data from the UK Biobank. Brain… read more here.
Keywords: brain; brain age; covid pandemic; accelerated brain ... See more keywords
The maternal X chromosome affects cognition and brain ageing in female mice
Sign Up to like & getrecommendations! Published in 2025 at "Nature"
DOI: 10.1038/s41586-024-08457-y
Abstract: Female mammalian cells have two X chromosomes, one of maternal origin and one of paternal origin. During development, one X chromosome randomly becomes inactivated1, 2, 3–4. This renders either the maternal X (Xm) chromosome or… read more here.
Keywords: cognition; chromosome; brain ageing; female mice ... See more keywords
Accelerated MRI-predicted brain ageing and its associations with cardiometabolic and brain disorders
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-76518-z
Abstract: Brain structure in later life reflects both influences of intrinsic aging and those of lifestyle, environment and disease. We developed a deep neural network model trained on brain MRI scans of healthy people to predict… read more here.
Keywords: brain ageing; accelerated mri; mri predicted; predicted brain ... See more keywords
Metabolic Dysfunction‐Associated Steatotic Liver Disease Is Associated With Accelerated Brain Ageing: A Population‐Based Study
Sign Up to like & getrecommendations! Published in 2025 at "Liver International"
DOI: 10.1111/liv.70109
Abstract: Metabolic dysfunction‐associated steatotic liver disease (MASLD) is linked to cognitive decline and dementia risk. We aimed to investigate the association between MASLD and brain ageing and explore the role of low‐grade inflammation. read more here.
Keywords: steatotic liver; dysfunction associated; liver disease; metabolic dysfunction ... See more keywords
Acupuncture promotes expression of Hsp84/86 and delays brain ageing in SAMP8 mice
Sign Up to like & getrecommendations! Published in 2019 at "Acupuncture in Medicine"
DOI: 10.1136/acupmed-2017-011577
Abstract: Objective: To study the effects of acupuncture on expression of heat shock protein (Hsp) 84 and 86, and brain ageing, in the senescence accelerated mouse prone 8 (SAMP8) model of Alzheimer’s disease. Methods: 7-month-old male… read more here.
Keywords: protein; acupuncture; brain ageing; expression ... See more keywords
The interaction between ageing and Alzheimer's disease: insights from the hallmarks of ageing
Sign Up to like & getrecommendations! Published in 2024 at "Translational Neurodegeneration"
DOI: 10.1186/s40035-024-00397-x
Abstract: Ageing is a crucial risk factor for Alzheimer’s disease (AD) and is characterised by systemic changes in both intracellular and extracellular microenvironments that affect the entire body instead of a single organ. Understanding the specific… read more here.
Keywords: alzheimer disease; disease; disease insights; interaction ageing ... See more keywords
Recent Neurotherapeutic Strategies to Promote Healthy Brain Aging: Are we there yet?
Sign Up to like & getrecommendations! Published in 2022 at "Aging and Disease"
DOI: 10.14336/ad.2021.0705
Abstract: Owing to the global exponential increase in population ageing, there is an urgent unmet need to develop reliable strategies to slow down and delay the ageing process. Age-related neurodegenerative diseases are among the main causes… read more here.
Keywords: promote healthy; brain ageing; recent neurotherapeutic; brain ... See more keywords
The Impact of Genes and Environment on Brain Ageing in Males Aged 51 to 72 Years
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2022.831002
Abstract: Magnetic resonance imaging data are being used in statistical models to predicted brain ageing (PBA) and as biomarkers for neurodegenerative diseases such as Alzheimer’s Disease. Despite their increasing application, the genetic and environmental etiology of… read more here.
Keywords: genes environment; brain ageing; environment brain; brain ... See more keywords
The BDNF Val66Met Polymorphism Modulates Resilience of Neurological Functioning to Brain Ageing and Dementia: A Narrative Review
Sign Up to like & getrecommendations! Published in 2020 at "Brain Sciences"
DOI: 10.3390/brainsci10040195
Abstract: Brain-derived neurotropic factor (BDNF) is an abundant and multi-function neurotrophin in the brain. It is released following neuronal activity and is believed to be particularly important in strengthening neural networks. A common variation in the… read more here.
Keywords: variation; ageing dementia; brain ageing; bdnf val66met ... See more keywords