Patterns of Regional Brain Atrophy and Brain Aging in Middle- and Older-Aged Adults With Type 1 Diabetes
Sign Up to like & getrecommendations! Published in 2023 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2023.16182
Abstract: This cohort study evaluates neuroimaging markers of brain age and Alzheimer disease–like atrophy in participants with type 1 diabetes and assesses the association between cognition and brain aging indices. read more here.
Keywords: brain aging; regional brain; brain; patterns regional ... See more keywords
The additive impact of cardio‐metabolic disorders and psychiatric illnesses on accelerated brain aging
Sign Up to like & getrecommendations! Published in 2022 at "Human Brain Mapping"
DOI: 10.1002/hbm.25769
Abstract: Severe mental illnesses (SMI) including major depressive disorder (MDD), bipolar disorder (BD), and schizophrenia spectrum disorder (SSD) elevate accelerated brain aging risks. Cardio‐metabolic disorders (CMD) are common comorbidities in SMI and negatively impact brain health.… read more here.
Keywords: smi cmd; cardio metabolic; brain aging; smi ... See more keywords
Brain age vector: A measure of brain aging with enhanced neurodegenerative disorder specificity
Sign Up to like & getrecommendations! Published in 2022 at "Human Brain Mapping"
DOI: 10.1002/hbm.26066
Abstract: Neuroimaging‐driven brain age estimation has become popular in measuring brain aging and identifying neurodegenerations. However, the single estimated brain age (gap) compromises regional variations of brain aging, losing spatial specificity across diseases which is valuable… read more here.
Keywords: age vector; brain aging; brain; brain age ... See more keywords
Brain aging and garbage cleaning
Sign Up to like & getrecommendations! Published in 2020 at "Seminars in Immunopathology"
DOI: 10.1007/s00281-020-00816-x
Abstract: Brain aging is a complex process involving many functions of our body and described by the interplay of a sleep pattern and changes in the metabolic waste concentration regulated by the microglial function and the… read more here.
Keywords: senescence; model; concentration; garbage ... See more keywords
Inflammatory markers and imaging patterns of advanced brain aging in the general population
Sign Up to like & getrecommendations! Published in 2019 at "Brain Imaging and Behavior"
DOI: 10.1007/s11682-019-00058-y
Abstract: Inflammaging describes the complexity between low-grade chronic inflammation with the pathogenesis of brain aging and Alzheimer´s disease (AD). We aimed to find associations of inflammatory markers: i) white blood cell count (WBC), ii) high-sensitivity C-reactive… read more here.
Keywords: fdr adjusted; inflammatory markers; atrophy; brain ... See more keywords
Assessing the joint effects of brain aging and gut microbiota on the risks of psychiatric disorders.
Sign Up to like & getrecommendations! Published in 2022 at "Brain imaging and behavior"
DOI: 10.1007/s11682-022-00630-z
Abstract: We aim to explore the potential interaction effects of brain aging and gut microbiota on the risks of sleep, anxiety and depression disorders. The genome-wide association study (GWAS) datasets of brain aging (N = 21,407) and gut… read more here.
Keywords: gut microbiota; aging gut; brain aging; effects brain ... See more keywords
Activation of the miR-34a-Mediated SIRT1/mTOR Signaling Pathway by Urolithin A Attenuates d-Galactose-Induced Brain Aging in Mice
Sign Up to like & getrecommendations! Published in 2019 at "Neurotherapeutics"
DOI: 10.1007/s13311-019-00753-0
Abstract: Despite tremendous advances in modern medicine, effective prevention or therapeutic strategies for age-related neurodegenerative diseases such as Alzheimer’s disease (AD) remain limited. Currently, accumulating evidence has demonstrated that microRNAs (miRNAs) are increasingly associated with age-related… read more here.
Keywords: induced brain; aging mice; mir 34a; signaling pathway ... See more keywords
NAD+ in Brain Aging and Neurodegenerative Disorders.
Sign Up to like & getrecommendations! Published in 2019 at "Cell metabolism"
DOI: 10.1016/j.cmet.2019.09.001
Abstract: NAD+ is a pivotal metabolite involved in cellular bioenergetics, genomic stability, mitochondrial homeostasis, adaptive stress responses, and cell survival. Multiple NAD+-dependent enzymes are involved in synaptic plasticity and neuronal stress resistance. Here, we review emerging… read more here.
Keywords: nad brain; aging neurodegenerative; neurodegenerative disorders; brain ... See more keywords
A specific immunity brain aging gene with a future
Sign Up to like & getrecommendations! Published in 2018 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2018.08.044
Abstract: The paper by James et al. [1] here extends previous work from the DRB1*13 overrides the harmful effects of apoE4 on the brain, acquires Minnesota group [2] on the protective effect of certain Human Leukocyte… read more here.
Keywords: presence; drb1; specific immunity; gene ... See more keywords
MRI characterization of rat brain aging at structural and functional level: Clues for translational applications
Sign Up to like & getrecommendations! Published in 2021 at "Experimental Gerontology"
DOI: 10.1016/j.exger.2021.111432
Abstract: Magnetic resonance imaging (MRI) paradigms, using non-invasive approaches, can provide relevant findings about brain aging. The attention has been primarily focused on neurodegenerative diseases, while little or nothing has been done to differentiate physiology from… read more here.
Keywords: characterization rat; level; mri characterization; rat brain ... See more keywords
DNA damage in the oligodendrocyte lineage and its role in brain aging
Sign Up to like & getrecommendations! Published in 2017 at "Mechanisms of Ageing and Development"
DOI: 10.1016/j.mad.2016.05.006
Abstract: Myelination is a recent evolutionary addition that significantly enhances the speed of transmission in the neural network. Even slight defects in myelin integrity impair performance and enhance the risk of neurological disorders. Indeed, myelin degeneration… read more here.
Keywords: dna damage; brain aging; oligodendrocyte lineage; damage ... See more keywords