Yes we can analyse amyloid images - Now What?
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Nuclear Medicine and Molecular Imaging"
DOI: 10.1007/s00259-017-3644-1
Abstract: With the recent introduction of amyloid PET tracers into clinical use, non-invasive biomarker information on brain amyloidosis is available which challenges the long-accepted gold standard of post mortem histopathology for diagnosing Alzheimer’s disease (AD). Phase… read more here.
Keywords: brain amyloid; amyloid; amyloid pet; pathology ... See more keywords
Amnestic MCI Patients’ Perspectives toward Disclosure of Amyloid PET Results in a Research Context
Sign Up to like & getrecommendations! Published in 2017 at "Neuroethics"
DOI: 10.1007/s12152-017-9313-z
Abstract: BackgroundResearchers currently are not obligated to share individual research results (IRR) with participants. This non-disclosure policy has been challenged on the basis of participants’ rights to be aware and in control of their personal medical… read more here.
Keywords: research; disclosure; brain amyloid; amyloid pet ... See more keywords
Multi-omics signature of brain amyloid deposition in asymptomatic individuals at-risk for Alzheimer's disease: The INSIGHT-preAD study
Sign Up to like & getrecommendations! Published in 2019 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2019.08.051
Abstract: Background One of the biggest challenge in Alzheimer's disease (AD) is to identify pathways and markers of disease prediction easily accessible, for prevention and treatment. Here we analysed blood samples from the INveStIGation of AlzHeimer's… read more here.
Keywords: multi omics; alzheimer disease; brain amyloid; insight pread ... See more keywords
Changes in brain amyloid-β accumulation after donepezil administration
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Neuroscience"
DOI: 10.1016/j.jocn.2017.08.025
Abstract: Recent studies using the mouse model of Alzheimer's disease (AD) have shown that donepezil administration reduces brain amyloid-β (Aβ) accumulation. This study investigated whether donepezil administration can reduce brain Aβ accumulation in human patients with… read more here.
Keywords: accumulation; amyloid accumulation; donepezil administration; brain amyloid ... See more keywords
Cognitive decline and brain amyloid-β accumulation across 3 years in adults with Down syndrome
Sign Up to like & getrecommendations! Published in 2017 at "Neurobiology of Aging"
DOI: 10.1016/j.neurobiolaging.2017.05.019
Abstract: Adults with Down syndrome (DS) have a high incidence of Alzheimer's disease (AD), providing a unique opportunity to explore the early, preclinical stages of AD neuropathology. We examined change in brain amyloid-β accumulation via the… read more here.
Keywords: accumulation; consistently pib; amyloid accumulation; brain amyloid ... See more keywords
Relationship Between Brain Amyloid Deposition and Instrumental Activities of Daily Living in Older Adults: A Longitudinal Study from the Multidomain Alzheimer Prevention Trial
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the American Geriatrics Society"
DOI: 10.1111/jgs.15497
Abstract: To examine the evolution of instrumental activity of daily living (IADL) performance according to the presence of brain amyloid deposition. read more here.
Keywords: relationship brain; brain amyloid; daily living; amyloid deposition ... See more keywords
Systolic Blood Pressure Is Associated with Increased Brain Amyloid Load in Mild Cognitively Impaired Participants: Alzheimer's Disease Neuroimaging Initiatives Study.
Sign Up to like & getrecommendations! Published in 2023 at "Dementia and geriatric cognitive disorders"
DOI: 10.1159/000528117
Abstract: BACKGROUND Cardiovascular disease (CVD), including elevated blood pressure (BP), is known to promote Alzheimer's disease (AD) risk. Although brain amyloid load is a recognized hallmark of pre-symptomatic AD, its relationship to increased BP is less… read more here.
Keywords: jnc; disease; brain; brain amyloid ... See more keywords
Decreased CSF clearance and increased brain amyloid in Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2022 at "Fluids and Barriers of the CNS"
DOI: 10.1186/s12987-022-00318-y
Abstract: Background In sporadic Alzheimer’s disease (AD), brain amyloid-beta (Aβ) deposition is believed to be a consequence of impaired Aβ clearance, but this relationship is not well established in living humans. CSF clearance, a major feature… read more here.
Keywords: clearance; alzheimer disease; csf clearance; brain amyloid ... See more keywords
Association of APOE-Independent Alzheimer Disease Polygenic Risk Score With Brain Amyloid Deposition in Asymptomatic Older Adults
Sign Up to like & getrecommendations! Published in 2022 at "Neurology"
DOI: 10.1212/wnl.0000000000200544
Abstract: Background and Objectives Brain amyloid deposition, a major risk factor for Alzheimer disease (AD), is currently estimated by measuring CSF or plasma amyloid peptide levels or by PET imaging. Assessing genetic risks relating to amyloid… read more here.
Keywords: disease; alzheimer disease; deposition; risk ... See more keywords
Aptamarker prediction of brain amyloid-β status in cognitively normal individuals at risk for Alzheimer's disease.
Sign Up to like & getrecommendations! Published in 2021 at "PloS one"
DOI: 10.1371/journal.pone.0243902
Abstract: The traditional approach to biomarker discovery for any pathology has been through hypothesis-based research one candidate at a time. The objective of this study was to develop an agnostic approach for the simultaneous screening of… read more here.
Keywords: alzheimer disease; cognitively normal; pathology; brain amyloid ... See more keywords