Associations of the Top 20 Alzheimer Disease Risk Variants With Brain Amyloidosis
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DOI: 10.1001/jamaneurol.2017.4198
Abstract: Importance Late-onset Alzheimer disease (AD) is highly heritable. Genome-wide association studies have identified more than 20 AD risk genes. The precise mechanism through which many of these genes are associated with AD remains unknown. Objective… read more here.
Keywords: association; brain amyloidosis; risk; disease ... See more keywords
Association of brain amyloidosis with pro-inflammatory gut bacterial taxa and peripheral inflammation markers in cognitively impaired elderly
Sign Up to like & getrecommendations! Published in 2017 at "Neurobiology of Aging"
DOI: 10.1016/j.neurobiolaging.2016.08.019
Abstract: The pathway leading from amyloid-β deposition to cognitive impairment is believed to be a cornerstone of the pathogenesis of Alzheimer's disease (AD). However, what drives amyloid buildup in sporadic nongenetic cases of AD is still… read more here.
Keywords: inflammatory; brain amyloidosis; brain; pro inflammatory ... See more keywords
Effect of Race on Prediction of Brain Amyloidosis by Plasma Aβ42/Aβ40, Phosphorylated Tau, and Neurofilament Light
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DOI: 10.1212/wnl.0000000000200358
Abstract: Background and Objectives To evaluate whether plasma biomarkers of amyloid (Aβ42/Aβ40), tau (p-tau181 and p-tau231), and neuroaxonal injury (neurofilament light chain [NfL]) detect brain amyloidosis consistently across racial groups. Methods Individuals enrolled in studies of… read more here.
Keywords: tau181 tau231; brain; status; plasma ... See more keywords
Relationships among Cortical Glutathione Levels, Brain Amyloidosis, and Memory in Healthy Older Adults Investigated In Vivo with 1H-MRS and Pittsburgh Compound-B PET
Sign Up to like & getrecommendations! Published in 2017 at "American Journal of Neuroradiology"
DOI: 10.3174/ajnr.a5143
Abstract: BACKGROUND AND PURPOSE: Oxidative stress has been implicated as an important pathologic mechanism in the development of Alzheimer disease. The purpose of this study was to assess whether glutathione levels, detected noninvasively with proton MR… read more here.
Keywords: spectroscopy; glutathione levels; brain amyloidosis; glutathione ... See more keywords