Association of Brain Atrophy With Disease Progression Independent of Relapse Activity in Patients With Relapsing Multiple Sclerosis.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA neurology"
DOI: 10.1001/jamaneurol.2022.1025
Abstract: Importance The mechanisms driving neurodegeneration and brain atrophy in relapsing multiple sclerosis (RMS) are not completely understood. Objective To determine whether disability progression independent of relapse activity (PIRA) in patients with RMS is associated with… read more here.
Keywords: relapse activity; brain; atrophy; brain atrophy ... See more keywords
Disease progression and brain atrophy in NMDAR encephalitis: Associated factor & clinical implication
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.51604
Abstract: We investigated the longitudinal pattern, determining factors, and clinical implications of brain volume changes in N‐methyl d‐aspartate receptor‐antibody (NMDAR) encephalitis. read more here.
Keywords: progression brain; nmdar encephalitis; brain; brain atrophy ... See more keywords
Brain atrophy patterns in multiple sclerosis patients treated with natalizumab and its clinical correlates
Sign Up to like & getrecommendations! Published in 2022 at "Brain and Behavior"
DOI: 10.1002/brb3.2573
Abstract: Multiple sclerosis (MS) is defined as a demyelinating disorder of the central nervous system, witnessing over the past years a remarkable progress in the therapeutic approaches of the inflammatory process. Yet, the ongoing neurodegenerative process… read more here.
Keywords: clinical correlates; multiple sclerosis; brain; brain atrophy ... See more keywords
Research on nonstroke dementia screening and cognitive function prediction model for older people based on brain atrophy characteristics
Sign Up to like & getrecommendations! Published in 2022 at "Brain and Behavior"
DOI: 10.1002/brb3.2726
Abstract: Brain atrophy is an important feature in dementia and is meaningful to explore a brain atrophy model to predict dementia. Using machine learning algorithm to establish a dementia model and cognitive function model based on… read more here.
Keywords: cognitive function; based brain; brain; brain atrophy ... See more keywords
Longitudinal brain atrophy distribution in advanced Parkinson's disease: What makes the difference in “cognitive status” converters?
Sign Up to like & getrecommendations! Published in 2019 at "Human Brain Mapping"
DOI: 10.1002/hbm.24884
Abstract: We investigated the brain atrophy distribution pattern and rate of regional atrophy change in Parkinson's disease (PD) in association with the cognitive status to identify the morphological characteristics of conversion to mild cognitive impairment (MCI)… read more here.
Keywords: brain atrophy; cognitive status; disease; atrophy ... See more keywords
A novel, likely pathogenic variant in UBTF‐related neurodegeneration with brain atrophy is associated with a severe divergent neurodevelopmental phenotype
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Genetics & Genomic Medicine"
DOI: 10.1002/mgg3.2054
Abstract: A de novo, pathogenic, missense variant in UBTF, c.628G>A p.Glu210Lys, has been described as the cause of an emerging neurodegenerative disorder, Childhood‐Onset Neurodegeneration with Brain Atrophy (CONDBA). The p.Glu210Lys alteration yields a positively charged stretch… read more here.
Keywords: variant ubtf; neurodegeneration brain; brain atrophy;
2D linear measures of ventricular enlargement may be relevant markers of brain atrophy and long-term disability progression in multiple sclerosis
Sign Up to like & getrecommendations! Published in 2020 at "European Radiology"
DOI: 10.1007/s00330-020-06738-4
Abstract: Objectives Aim of this study was to investigate the reliability and validity of 2D linear measures of ventricular enlargement as indirect markers of brain atrophy and possible predictors of clinical disability. Methods In this retrospective… read more here.
Keywords: brain atrophy; disability; year; ventricular enlargement ... See more keywords
Handgrip strength and lean mass are independently related to brain atrophy among alcoholics.
Sign Up to like & getrecommendations! Published in 2019 at "Clinical nutrition"
DOI: 10.1016/j.clnu.2018.06.965
Abstract: BACKGROUND In neurodegenerative disorders or in normal aging humans a relationship between muscle mass and/or performance and brain volume was observed, that is not dependent on age or other confounding factors. The aim of the… read more here.
Keywords: handgrip strength; brain atrophy; lean mass; atrophy ... See more keywords
Quantitative analysis of brain atrophy in patients with xeroderma pigmentosum group A carrying the founder mutation in Japan
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the Neurological Sciences"
DOI: 10.1016/j.jns.2017.08.3238
Abstract: INTRODUCTION Xeroderma pigmentosum (XP) is an inherited congenital disease presenting with dermatological and neurological manifestations. In Japan, XP complementation group A (XP-A) is most frequently observed in eight clinical subtypes, and the homozygous founder mutation,… read more here.
Keywords: atrophy patients; brain; brain atrophy; founder mutation ... See more keywords
THE IMPACT OF BRAIN ATROPHY IN THE YOUNG PATIENT WITH SEVERE HEART FAILURE
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the American College of Cardiology"
DOI: 10.1016/s0735-1097(18)31443-8
Abstract: Recently, several reports recognized the heart failure(HF) effected the brain impairment by impaired vascular blood flow and brain atrophy. However, there are no report mentioned the relationship brain atrophy and the mortality in young patient… read more here.
Keywords: brain atrophy; heart failure; young patient; patient severe ... See more keywords
CID1067700, a late endosome GTPase Rab7 receptor antagonist, attenuates brain atrophy, improves neurologic deficits and inhibits reactive astrogliosis in rat ischemic stroke
Sign Up to like & getrecommendations! Published in 2018 at "Acta Pharmacologica Sinica"
DOI: 10.1038/s41401-018-0166-8
Abstract: Increasing evidence suggests that Ras-related in brain 7 (Rab7), an endosome-localized small GTPase contributes to cerebral ischemic brain injury. In the present study, we investigated the role of Rab7 in ischemic stroke-induced formation of astrogliosis… read more here.
Keywords: ischemic stroke; brain atrophy; neurologic deficits; rab7 ... See more keywords