Role of the Gut-Brain Axis in the Shared Genetic Etiology Between Gastrointestinal Tract Diseases and Psychiatric Disorders
Sign Up to like & getrecommendations! Published in 2023 at "JAMA Psychiatry"
DOI: 10.1001/jamapsychiatry.2022.4974
Abstract: Key Points Question To what extent are shared genetic determinants in the comorbidities and associations between gastrointestinal tract diseases and psychiatry disorders involved in the gut-brain axis? Findings In this genome-wide pleiotropic association study using… read more here.
Keywords: brain axis; shared genetic; etiology; gut brain ... See more keywords
Ultrasound‐Activated Nanoprobiotic Hydrogel Disrupts the Oral‐Brain Axis to Alleviate Diabetic Periodontitis and Cognitive Decline
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202511408
Abstract: Diabetes‐associated periodontitis and cognitive dysfunction form a vicious cycle that impairs tissue repair. Polyphenol‐engineered artificial nanoprobiotics using ultrasound‐responsive dihydrocaffeic acid (DA)‐mediated Fe/Zn bimetallic porphyrin MOFs (Fe‐TCPP‐DA‐Zn), integrated into adaptive hydrogels, is developed. This design enables… read more here.
Keywords: oral brain; diabetic periodontitis; periodontitis cognitive; brain ... See more keywords
Mechanistic Insights into a Smart Nanomotor‐Laden Inulin Hydrogel Reprogramming Gut‐Brain Axis for Combinatorial Inflammatory Bowel Disease‐Depression Therapy
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202519453
Abstract: Depression prevalence is significantly higher (20‐40%) in inflammatory bowel disease (IBD) patients than the general population. Dysregulation of the gut microbiota‐brain axis (GM‐BA) is implicated in IBD‐associated depression pathogenesis, involving M1 macrophage‐driven neuroinflammation. While glycyrrhizic… read more here.
Keywords: hydrogel; brain axis; depression; bowel disease ... See more keywords
Inflammation, Lifestyle Factors, and the Microbiome-Gut-Brain Axis: Relevance to Depression and Antidepressant Action.
Sign Up to like & getrecommendations! Published in 2022 at "Clinical pharmacology and therapeutics"
DOI: 10.1002/cpt.2581
Abstract: Depression is considered a major public health concern, where existing pharmacological treatments are not equally effective across all patients. The pathogenesis of depression involves the interaction of complex biological components such as the immune system… read more here.
Keywords: gut brain; action; brain axis; depression ... See more keywords
Obesity and gut–microbiota–brain axis: A narrative review
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.24420
Abstract: Obesity is a major health problem that is associated with many physiological and mental disorders, such as diabetes, stroke, and depression. Gut microbiota has been affirmed to interact with various organs, including the brain. Intestinal… read more here.
Keywords: brain axis; gut microbiota; brain; obesity ... See more keywords
The placenta‐brain‐axis
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.24603
Abstract: All mammalian species depend on the placenta, a transient organ, for exchange of gases, nutrients, and waste between the mother and conceptus. Besides serving as a conduit for such exchanges, the placenta produces hormones and… read more here.
Keywords: placenta; brain axis; physiology; placenta brain ... See more keywords
[From gut feeling to visceral pain : Effects of negative expectations in the context of the gut-brain axis].
Sign Up to like & getrecommendations! Published in 2021 at "Schmerz"
DOI: 10.1007/s00482-021-00614-w
Abstract: Disturbances of the gut-brain axis are characterized by complex dysfunctions on peripheral and central nervous system levels, which can contribute to visceral hypervigilance and hyperalgesia and imprint visceral pain. Numerous cognitive, emotional and psychoneurobiological factors… read more here.
Keywords: gut brain; visceral pain; brain axis; pain ... See more keywords
The Role of Epigenomic Regulatory Pathways in the Gut-Brain Axis and Visceral Hyperalgesia.
Sign Up to like & getrecommendations! Published in 2021 at "Cellular and molecular neurobiology"
DOI: 10.1007/s10571-021-01108-0
Abstract: The gut-brain axis (GBA) is broadly accepted to describe the bidirectional circuit that links the gastrointestinal tract with the central nervous system (CNS). Interest in the GBA has grown dramatically over past two decades along… read more here.
Keywords: visceral hyperalgesia; hyperalgesia; brain axis; epigenomic regulatory ... See more keywords
Activation of the muscle-to-brain axis ameliorates neurocognitive deficits in an Alzheimer’s disease mouse model via enhancing neurotrophic and synaptic signaling
Sign Up to like & getrecommendations! Published in 2024 at "GeroScience"
DOI: 10.1007/s11357-024-01345-3
Abstract: INTRODUCTION Skeletal muscle regulates central nervous system (CNS) function and health, activating the muscle-to-brain axis through the secretion of skeletal muscle originating factors (‘myokines’) with neuroprotective properties. However, the precise mechanisms underlying these benefits in… read more here.
Keywords: skeletal muscle; alzheimer disease; brain axis; muscle ... See more keywords
Sex Differences in the Gut-Brain Axis: Implications for Mental Health
Sign Up to like & getrecommendations! Published in 2020 at "Current Psychiatry Reports"
DOI: 10.1007/s11920-020-01202-y
Abstract: Purpose of Review The purpose of this article is to highlight how sex differences in the gut-brain axis may contribute to the discrepancies in incidence of neurodevelopmental, psychiatric, and neurodegenerative disorders between females and males.… read more here.
Keywords: differences gut; sex differences; brain axis; sex ... See more keywords
Inflammasome-Regulated Pyroptotic Cell Death in Disruption of the Gut-Brain Axis After Stroke.
Sign Up to like & getrecommendations! Published in 2022 at "Translational stroke research"
DOI: 10.1007/s12975-022-01005-8
Abstract: Approximately 50% of stroke survivors experience gastrointestinal complications. The innate immune response plays a role in changes to the gut-brain axis after stroke. The purpose of this study is to examine the importance of inflammasome-mediated… read more here.
Keywords: gut brain; disruption gut; brain axis; stroke ... See more keywords