Copy number variations across the blood–brain barrier in multiple sclerosis
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.51573
Abstract: Multiple sclerosis (MS) is a neuroinflammatory disease where immune cells cross the blood–brain barrier (BBB) into the central nervous system (CNS). What predisposes these immune cells to cross the BBB is still unknown. Here, we… read more here.
Keywords: blood; blood brain; multiple sclerosis; brain barrier ... See more keywords
Engineering the Human Blood–Brain Barrier at the Capillary Scale using a Double‐Templating Technique
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202110289
Abstract: In vitro blood–brain barrier (BBB) models have played an important role in studying processes such as immune cell trafficking and drug delivery, as well as contributing to the understanding of mechanisms of disease progression. Many… read more here.
Keywords: capillary scale; brain barrier; blood brain; brain ... See more keywords
NIR‐Assisted MgO‐Based Polydopamine Nanoparticles for Targeted Treatment of Parkinson's Disease through the Blood–Brain Barrier
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202201655
Abstract: The blood–brain barrier (BBB) is a major limiting factor that prevents the treatment of Parkinson's disease (PD). In the present study, MgOp@PPLP nanoparticles are explored by using MgO nanoparticles as a substrate, polydopamine as a… read more here.
Keywords: mgop pplp; blood brain; brain barrier; brain ... See more keywords
Overcoming the Blood-Brain Barrier: The Role of Nanomaterials in Treating Neurological Diseases.
Sign Up to like & getrecommendations! Published in 2018 at "Advanced materials"
DOI: 10.1002/adma.201801362
Abstract: Therapies directed toward the central nervous system remain difficult to translate into improved clinical outcomes. This is largely due to the blood-brain barrier (BBB), arguably the most tightly regulated interface in the human body, which… read more here.
Keywords: blood brain; brain; neurological diseases; brain barrier ... See more keywords
3D In Vitro Blood‐Brain‐Barrier Model for Investigating Barrier Insults
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202205752
Abstract: The blood-brain-barrier (BBB) prevents that harmful substances in the blood enter the brain, and barrier disruption has been associated with a variety of central-nervous-system diseases. In vitro BBB models enable to recapitulate the BBB behavior… read more here.
Keywords: blood brain; bbb; barrier; brain barrier ... See more keywords
Apremilast exerts protective effects on stroke outcomes and blood–brain barrier (BBB) dysfunction through regulating Rho‐associated protein kinase 2 expression
Sign Up to like & getrecommendations! Published in 2022 at "Brain and Behavior"
DOI: 10.1002/brb3.2677
Abstract: Stroke is a devastating event and a huge public health concern worldwide. Apremilast (APR) is a selective inhibitor of phosphodiesterase‐4 involved in various neurological diseases, including stroke. However, the protective effects of APR on stroke… read more here.
Keywords: protective effects; blood brain; brain barrier; brain ... See more keywords
Indoloazepinone‐Constrained Oligomers as Cell‐Penetrating and Blood–Brain‐Barrier‐Permeating Compounds
Sign Up to like & getrecommendations! Published in 2018 at "ChemBioChem"
DOI: 10.1002/cbic.201700678
Abstract: Non‐cationic and amphipathic indoloazepinone‐constrained (Aia) oligomers have been synthesized as new vectors for intracellular delivery. The conformational preferences of the [l‐Aia‐Xxx]n oligomers were investigated by circular dichroism (CD) and NMR spectroscopy. Whereas Boc‐[l‐Aia‐Gly]2,4‐OBn oligomers 12… read more here.
Keywords: blood brain; aia; boc aia; indoloazepinone constrained ... See more keywords
Investigation of the Transporting Behavior of Framework DNA Nano‐Devices Across the Artificial Blood‐Brain Barrier (BBB)
Sign Up to like & getrecommendations! Published in 2022 at "ChemBioChem"
DOI: 10.1002/cbic.202200459
Abstract: This study focused on exploring the ability of self‐assembled DNA frameworks to cross the blood‐brain barrier (BBB). We designed and assembled a series of DNA origami structures with equal quantity of nucleic acid materials but… read more here.
Keywords: blood brain; barrier bbb; brain barrier; dna ... See more keywords
Blood–brain barrier permeable benzylpiperidin‐4‐yl‐linked benzylamino benzamides as dual cholinesterase inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "Drug Development Research"
DOI: 10.1002/ddr.21997
Abstract: Alzheimer's disease (AD) is a multifaceted neurodegenerative disorder involving various pathological events. The existing options for managing the disease utterly rely on cholinesterase (ChE) inhibitors. In recent years, the dual inhibition of ChEs as a… read more here.
Keywords: blood brain; barrier permeable; brain barrier; che inhibitors ... See more keywords
Neuroprotection and Blood–Brain Barrier Restoration by Salubrinal After a Cortical Stab Injury
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.25655
Abstract: Following a central nervous system (CNS) injury, restoration of the blood‐brain barrier (BBB) integrity is essential for recovering homeostasis. When this process is delayed or impeded, blood substances and cells enter the CNS parenchyma, initiating… read more here.
Keywords: blood brain; stab injury; restoration; blood ... See more keywords
Mycobacterium tuberculosis causes a leaky blood‐brain barrier and neuroinflammation in the prefrontal cortex and cerebellum regions of infected mice offspring
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Developmental Neuroscience"
DOI: 10.1002/jdn.10116
Abstract: The maternal system's exposure to pathogens influences foetal brain development through the influx of maternal cytokines and activation of the foetal immune status to a persistent inflammatory state characterised by glia cell activation. Neuroinflammation influences… read more here.
Keywords: blood brain; mtb; neuroinflammation; tuberculosis ... See more keywords