Oligodendrocyte progenitor cell maturation is dependent on dual function of MCT8 in the transport of thyroid hormone across brain barriers and the plasma membrane
Sign Up to like & getrecommendations! Published in 2021 at "Glia"
DOI: 10.1002/glia.24014
Abstract: Inactivating mutations in the thyroid hormone (TH) transporter monocarboxylate transporter 8 (MCT8) causes a rare and debilitating form of X‐linked psychomotor disability known as Allan Herndon Dudley syndrome (AHDS). One of the most prominent pathophysiological… read more here.
Keywords: mct8; across brain; oligodendrocyte progenitor; maturation ... See more keywords
Treating brain diseases using systemic parenterally-administered protein therapeutics: Dysfunction of the brain barriers and potential strategies.
Sign Up to like & getrecommendations! Published in 2020 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2020.120461
Abstract: The parenteral administration of protein therapeutics is increasingly gaining importance for the treatment of human diseases. However, the presence of practically impermeable blood-brain barriers greatly restricts access of such pharmaceutics to the brain. Treating brain… read more here.
Keywords: protein therapeutics; treating brain; brain diseases; brain barriers ... See more keywords
Overcoming the Brain Barriers: From Immune Cells to Nanoparticles.
Sign Up to like & getrecommendations! Published in 2019 at "Trends in pharmacological sciences"
DOI: 10.1016/j.tips.2019.11.001
Abstract: Nanoparticulate carriers, often referred to as nanoparticles (NPs), represent an important pharmacological advance for drug protection and tissue-specific drug delivery. Accessing the central nervous system (CNS), however, is a complex process regulated by mainly three… read more here.
Keywords: barriers immune; overcoming brain; cells nanoparticles; immune cells ... See more keywords
Claudin-3-deficient C57BL/6J mice display intact brain barriers
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-018-36731-3
Abstract: The tight junction protein claudin-3 has been identified as a transcriptional target of the Wnt/β-catenin signaling pathway regulating blood-brain barrier (BBB) maturation. In neurological disorders loss of claudin-3 immunostaining is observed at the compromised BBB… read more here.
Keywords: brain barriers; brain; claudin; c57bl mice ... See more keywords
Central nervous system zoning: How brain barriers establish subdivisions for CNS immune privilege and immune surveillance.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of internal medicine"
DOI: 10.1111/joim.13469
Abstract: The central nervous system (CNS) coordinates all our body functions. Neurons in the CNS parenchyma achieve this computational task by high speed communication via electrical and chemical signals and thus rely on a strictly regulated… read more here.
Keywords: system; cns immune; brain barriers; cns parenchyma ... See more keywords
Current research into brain barriers and the delivery of therapeutics for neurological diseases: a report on CNS barrier congress London, UK, 2017
Sign Up to like & getrecommendations! Published in 2017 at "Fluids and Barriers of the CNS"
DOI: 10.1186/s12987-017-0079-9
Abstract: This is a report on the CNS barrier congress held in London, UK, March 22–23rd 2017 and sponsored by Kisaco Research Ltd. The two 1-day sessions were chaired by John Greenwood and Margareta Hammarlund-Udenaes, respectively,… read more here.
Keywords: report cns; barrier congress; neurological diseases; cns barrier ... See more keywords
This was the year that was: brain barriers and brain fluid research in 2019
Sign Up to like & getrecommendations! Published in 2020 at "Fluids and Barriers of the CNS"
DOI: 10.1186/s12987-020-00181-9
Abstract: This editorial highlights advances in brain barrier and brain fluid research published in 2019, as well as addressing current controversies and pressing needs. Topics include recent advances related to: the cerebral endothelium and the neurovascular… read more here.
Keywords: brain fluid; fluid; barriers brain; fluid research ... See more keywords
Structure and Junctional Complexes of Endothelial, Epithelial and Glial Brain Barriers
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms20215372
Abstract: The homeostasis of the central nervous system (CNS) is ensured by the endothelial, epithelial, mesothelial and glial brain barriers, which strictly control the passage of molecules, solutes and immune cells. While the endothelial blood-brain barrier… read more here.
Keywords: endothelial epithelial; junctional complexes; glial brain; brain barriers ... See more keywords