Chemical‐Driven Outflow of Dissociated Amyloid Burden from Brain to Blood
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202104542
Abstract: Amyloid‐β (Aβ) deposition in the brain is a primary biomarker of Alzheimer's disease (AD) and Aβ measurement for AD diagnosis mostly depends on brain imaging and cerebrospinal fluid analyses. Blood Aβ can become a reliable… read more here.
Keywords: amyloid burden; brain; chemical; brain blood ... See more keywords
Postmortem Brain-Blood Ratios of Amphetamine, Cocaine, Ephedrine, MDMA and Methylphenidate.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of analytical toxicology"
DOI: 10.1093/jat/bky110
Abstract: Brain tissue may serve as a useful supplement to blood in postmortem investigations. However, reference concentrations for central stimulant drugs are scarce in brain tissue. This study involves some frequently used stimulants: amphetamine, cocaine, ephedrine,… read more here.
Keywords: ephedrine; brain blood; blood ratios; mdma ... See more keywords
Brain differential gene expression and blood cross-validation of a molecular signature of patients with major depressive disorder
Sign Up to like & getrecommendations! Published in 2022 at "Psychiatric Genetics"
DOI: 10.1097/ypg.0000000000000309
Abstract: Introduction The agreement between clinicians diagnosing major depressive disorder (MDD) is poor. The objective of this study was to identify a reproducible and robust gene expression marker capable of differentiating MDD from healthy control (HC)… read more here.
Keywords: gene expression; gene; brain; brain blood ... See more keywords
A Whole Methylome Study of Ethanol Exposure in Brain and Blood: An Exploration of the Utility of Peripheral Blood as Proxy Tissue for Brain in Alcohol Methylation Studies
Sign Up to like & getrecommendations! Published in 2018 at "Alcoholism: Clinical and Experimental Research"
DOI: 10.1111/acer.13905
Abstract: BACKGROUND Recent reviews have highlighted the potential use of blood-based methylation biomarkers as diagnostic and prognostic tools of current and future alcohol use and addiction. Due to the substantial overlap that often exists between methylation… read more here.
Keywords: methylation; brain blood; blood; brain ... See more keywords
Two-Photon Imaging Reveals Capillary Occlusions are Responsible for Reduced Brain Blood Flow and Cognitive Decline in Alzheimer’s Disease Mouse Models
Sign Up to like & getrecommendations! Published in 2017 at "Brain"
DOI: 10.1364/brain.2017.brw3b.3
Abstract: Using in vivo nonlinear microscopy, we found 2% of brain capillaries were occluded by an adhered leukocyte in Alzheimer’s disease mice. Blocking this adhesion eliminated these stalls, improved brain blood flow by 30%, and restored… read more here.
Keywords: blood flow; alzheimer disease; brain; brain blood ... See more keywords
Brain blood vessel autoantibodies in patients with NMDA and GABAA receptor encephalitis: identification of unconventional Myosin-X as target antigen
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2023.1077204
Abstract: Introduction: The antibody repertoire from CSF-derived antibody-secreting cells and memory B-cells in patients with encephalitis contains a considerable number of antibodies that do not target the disease-defining autoantigen such as the GABA or NMDA receptors.… read more here.
Keywords: brain; receptor encephalitis; brain blood; blood ... See more keywords
Donepezil Brain and Blood Pharmacokinetic Modeling after Nasal Film and Oral Solution Administration in Mice
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics15051409
Abstract: Intranasal delivery is a non-invasive mode of administration, gaining popularity due to its potential for targeted delivery to the brain. The anatomic connection of the nasal cavity with the central nervous system (CNS) is based… read more here.
Keywords: nasal; administration; brain; modeling nasal ... See more keywords