Therapeutic effectiveness and safety of sequential ICIs with radiotherapy for symptomatic brain and bone metastases in NSCLC patients
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DOI: 10.1097/md.0000000000031665
Abstract: In advanced non-small cell lung cancer (NSCLC), the brain and bones are common metastatic sites, and the disease seriously affects the survival time and quality of life. For metastatic lesions with symptoms, local treatment often… read more here.
Keywords: symptomatic brain; radiotherapy; brain; brain bone ... See more keywords
ANP32A regulates ATM expression and prevents oxidative stress in cartilage, brain, and bone
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DOI: 10.1126/scitranslmed.aar8426
Abstract: ANP32A is a transcriptional regulator of ATM and provides protection against oxidative stress to prevent joint, brain, and bone disease. Oxidative stress and osteoarthritis Osteoarthritis is a common degenerative joint disorder that affects cartilage and… read more here.
Keywords: anp32a; brain bone; stress; cartilage ... See more keywords
Current Radiotherapy Concepts Regarding Brain and Bone Metastases in Centers Participating in the German-Danish Interreg-Project TreaT
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DOI: 10.21873/invivo.13083
Abstract: Abstract Background/Aim: Radiotherapy regimens for brain or bone metastases vary substantially. This study compared regimens utilized in Northern Germany and Denmark. Patients and Methods: Three centers participating in the Interreg-Project TreaT completed questionnaires regarding preferred… read more here.
Keywords: prognosis; radiotherapy; brain; brain bone ... See more keywords
Morphological Phenotyping of Organotropic Brain- and Bone-Seeking Triple Negative Metastatic Breast Tumor Cells
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DOI: 10.3389/fcell.2022.790410
Abstract: Triple negative breast cancer (TNBC) follows a non-random pattern of metastasis to the bone and brain tissue. Prior work has found that brain-seeking breast tumor cells display altered proteomic profiles, leading to alterations in pathways… read more here.
Keywords: triple negative; bone; tissue; cell ... See more keywords
Brain–Bone Axis in Physiological and Pathological Conditions
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DOI: 10.3390/ijms26199822
Abstract: The brain–bone axis has garnered increasing attention over the years, leading to numerous studies that have unraveled the intricate bidirectional communication between the central nervous system (CNS) and skeletal metabolism. This review explores this profound… read more here.
Keywords: axis physiological; brain bone; physiological pathological; bone axis ... See more keywords