Nanoscale‐tipped wire array injections transfer DNA directly into brain cells ex vivo and in vivo
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13377
Abstract: Genetic modification to restore cell functions in the brain can be performed through the delivery of biomolecules in a minimally invasive manner into live neuronal cells within brain tissues. However, conventional nanoscale needles are too… read more here.
Keywords: brain; vivo vivo; neuronal cells; wire ... See more keywords
How to Study the Uptake and Toxicity of Nanoparticles in Cultured Brain Cells: The Dos and Don’t Forgets
Sign Up to like & getrecommendations! Published in 2018 at "Neurochemical Research"
DOI: 10.1007/s11064-018-2598-4
Abstract: Due to their exciting properties, engineered nanoparticles have obtained substantial attention over the last two decades. As many types of nanoparticles are already used for technical and biomedical applications, the chances that cells in the… read more here.
Keywords: uptake toxicity; study uptake; nanoparticles cultured; brain ... See more keywords
Glucose Can Epigenetically Alter the Gene Expression of Neurotrophic Factors in the Murine Brain Cells
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Neurobiology"
DOI: 10.1007/s12035-017-0578-3
Abstract: Glucose is believed to improve the memory in both human and mice, but the detailed insights were mostly elusive. In this study, we focused on two major neurotrophic factors, brain-derived neurotrophic factor (BDNF) and fibroblast… read more here.
Keywords: glucose epigenetically; brain; expression; neurotrophic factors ... See more keywords
Gliomas Interact with Non-glioma Brain Cells via Extracellular Vesicles.
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.01.089
Abstract: Emerging evidence suggests that crosstalk between glioma cells and the brain microenvironment may influence brain tumor growth. To date, known reciprocal interactions among these cells have been limited to the release of paracrine factors. Combining… read more here.
Keywords: extracellular vesicles; glioma brain; glioma; non glioma ... See more keywords
Visual Perception: Human Brain Cells Cause a Change of View
Sign Up to like & getrecommendations! Published in 2020 at "Current Biology"
DOI: 10.1016/j.cub.2020.06.054
Abstract: Some images spontaneously change in appearance. A new study has found that these changes are reflected in high-level visual cortical areas before they become apparent in early sensory cortex. This suggests that visual information not only… read more here.
Keywords: perception human; cells cause; human brain; brain ... See more keywords
C-55 Normal Brain Cells in Abnormal Places: Contributions of Conjoint Neuropsychological, Pediatric, Neurologic, and Psychiatric Assessment in the Diagnosis and Behavioral Management of Pediatric Subependymal Heterotopia
Sign Up to like & getrecommendations! Published in 2019 at "Archives of Clinical Neuropsychology"
DOI: 10.1093/arclin/acz034.217
Abstract: Subependymal heterotopia (SH) is a development brain malformation from abnormal neuronal proliferation and migration resulting in developmental delays and focal childhood epilepsy (Barkovich, 2000). SH results from the interruption of normal gray matter migration beneath… read more here.
Keywords: subependymal heterotopia; normal brain; assessment; brain ... See more keywords
Adeno-Associated Virus Toolkit to Target Diverse Brain Cells.
Sign Up to like & getrecommendations! Published in 2022 at "Annual review of neuroscience"
DOI: 10.1146/annurev-neuro-111020-100834
Abstract: Recombinant adeno-associated viruses (AAVs) are commonly used gene delivery vehicles for neuroscience research. They have two engineerable features: the capsid (outer protein shell) and cargo (encapsulated genome). These features can be modified to enhance cell… read more here.
Keywords: associated virus; brain; adeno associated; brain cells ... See more keywords
Protective effect of sakuranetin in brain cells of dementia model rats.
Sign Up to like & getrecommendations! Published in 2019 at "Cellular and molecular biology"
DOI: 10.14715/cmb/2019.65.5.9
Abstract: Alzheimer's disease (AD) is a high-incidence neurodegenerative disease with complex and diverse pathogenesis. With aging of the population and continuous improvement of living standards, the incidence of AD is on the increase. Therefore, there is… read more here.
Keywords: sak; sakuranetin; effect; model ... See more keywords
Brain Cells Release Calreticulin That Attracts and Activates Microglia, and Inhibits Amyloid Beta Aggregation and Neurotoxicity
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.859686
Abstract: Calreticulin is a chaperone, normally found in the endoplasmic reticulum, but can be released by macrophages into the extracellular medium. It is also found in cerebrospinal fluid bound to amyloid beta (Aβ). We investigated whether… read more here.
Keywords: calreticulin; amyloid beta; brain cells; release calreticulin ... See more keywords
Extracellular Vesicles Cargo in Modulating Microglia Functional Responses
Sign Up to like & getrecommendations! Published in 2022 at "Biology"
DOI: 10.3390/biology11101426
Abstract: Simple Summary Extracellular vesicles (EVs) are considered a new additional mechanism of intercellular communication also in brain cells. Microglia are brain-resident immune cells that provided to immune surveillance and inflammatory responses in the central nervous… read more here.
Keywords: extracellular vesicles; inflammatory state; brain; evs ... See more keywords
Oxidized Cell-Free DNA Rapidly Skews the Transcriptional Profile of Brain Cells toward Boosting Neurogenesis and Neuroplasticity.
Sign Up to like & getrecommendations! Published in 2021 at "Current issues in molecular biology"
DOI: 10.3390/cimb43030112
Abstract: Cell-free DNA (cfDNA) is liberated and accumulated in neural tissue due to cell damage. The oxidative and nitrosative stress in the brain that accompanies various pathological conditions has been shown to increase the oxidation of… read more here.
Keywords: free dna; cell free; neurogenesis neuroplasticity; cfdna ... See more keywords