Nanoscale‐tipped wire array injections transfer DNA directly into brain cells ex vivo and in vivo
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13377
Abstract: Genetic modification to restore cell functions in the brain can be performed through the delivery of biomolecules in a minimally invasive manner into live neuronal cells within brain tissues. However, conventional nanoscale needles are too… read more here.
Keywords: brain; vivo vivo; neuronal cells; wire ... See more keywords
Implications of organophosphate pesticides on brain cells and their contribution toward progression of Alzheimer's disease
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23660
Abstract: The most widespread neurodegenerative disorder, Alzheimer's disease (AD) is marked by severe behavioral abnormalities, cognitive and functional impairments. It is inextricably linked with the deposition of amyloid β (Aβ) plaques and tau protein in the… read more here.
Keywords: alzheimer disease; organophosphate pesticides; brain cells; brain ... See more keywords
How to Study the Uptake and Toxicity of Nanoparticles in Cultured Brain Cells: The Dos and Don’t Forgets
Sign Up to like & getrecommendations! Published in 2018 at "Neurochemical Research"
DOI: 10.1007/s11064-018-2598-4
Abstract: Due to their exciting properties, engineered nanoparticles have obtained substantial attention over the last two decades. As many types of nanoparticles are already used for technical and biomedical applications, the chances that cells in the… read more here.
Keywords: uptake toxicity; study uptake; nanoparticles cultured; brain ... See more keywords
Glucose Can Epigenetically Alter the Gene Expression of Neurotrophic Factors in the Murine Brain Cells
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Neurobiology"
DOI: 10.1007/s12035-017-0578-3
Abstract: Glucose is believed to improve the memory in both human and mice, but the detailed insights were mostly elusive. In this study, we focused on two major neurotrophic factors, brain-derived neurotrophic factor (BDNF) and fibroblast… read more here.
Keywords: glucose epigenetically; brain; expression; neurotrophic factors ... See more keywords
Gliomas Interact with Non-glioma Brain Cells via Extracellular Vesicles.
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.01.089
Abstract: Emerging evidence suggests that crosstalk between glioma cells and the brain microenvironment may influence brain tumor growth. To date, known reciprocal interactions among these cells have been limited to the release of paracrine factors. Combining… read more here.
Keywords: extracellular vesicles; glioma brain; glioma; non glioma ... See more keywords
Visual Perception: Human Brain Cells Cause a Change of View
Sign Up to like & getrecommendations! Published in 2020 at "Current Biology"
DOI: 10.1016/j.cub.2020.06.054
Abstract: Some images spontaneously change in appearance. A new study has found that these changes are reflected in high-level visual cortical areas before they become apparent in early sensory cortex. This suggests that visual information not only… read more here.
Keywords: perception human; cells cause; human brain; brain ... See more keywords
C-55 Normal Brain Cells in Abnormal Places: Contributions of Conjoint Neuropsychological, Pediatric, Neurologic, and Psychiatric Assessment in the Diagnosis and Behavioral Management of Pediatric Subependymal Heterotopia
Sign Up to like & getrecommendations! Published in 2019 at "Archives of Clinical Neuropsychology"
DOI: 10.1093/arclin/acz034.217
Abstract: Subependymal heterotopia (SH) is a development brain malformation from abnormal neuronal proliferation and migration resulting in developmental delays and focal childhood epilepsy (Barkovich, 2000). SH results from the interruption of normal gray matter migration beneath… read more here.
Keywords: subependymal heterotopia; normal brain; assessment; brain ... See more keywords
Alpha_Mesh_Swc: automatic and robust surface mesh generation from the skeleton description of brain cells
Sign Up to like & getrecommendations! Published in 2025 at "Briefings in Bioinformatics"
DOI: 10.1093/bib/bbaf258
Abstract: Abstract In recent years, there has been a significant increase in publicly available skeleton descriptions of real brain cells from laboratories all over the world. In theory, this should make it is possible to perform… read more here.
Keywords: brain; brain cells; alpha mesh; surface ... See more keywords
Extensive long-range polycomb interactions and weak compartmentalization are hallmarks of human neuronal 3D genome
Sign Up to like & getrecommendations! Published in 2024 at "Nucleic Acids Research"
DOI: 10.1101/2023.08.04.551939
Abstract: Chromatin architecture regulates gene expression and shapes cellular identity, particularly in neuronal cells. Specifically, polycomb group (PcG) proteins enable establishment and maintenance of neuronal cell type by reorganizing chromatin into repressive domains that limit the… read more here.
Keywords: range polycomb; brain cells; expression; long range ... See more keywords
Adeno-Associated Virus Toolkit to Target Diverse Brain Cells.
Sign Up to like & getrecommendations! Published in 2022 at "Annual review of neuroscience"
DOI: 10.1146/annurev-neuro-111020-100834
Abstract: Recombinant adeno-associated viruses (AAVs) are commonly used gene delivery vehicles for neuroscience research. They have two engineerable features: the capsid (outer protein shell) and cargo (encapsulated genome). These features can be modified to enhance cell… read more here.
Keywords: associated virus; brain; adeno associated; brain cells ... See more keywords
Spatial transcriptomic brain imaging reveals the effects of immunomodulation therapy on specific regional brain cells in a mouse dementia model
Sign Up to like & getrecommendations! Published in 2024 at "BMC Genomics"
DOI: 10.1186/s12864-024-10434-8
Abstract: Increasing evidence of brain-immune crosstalk raises expectations for the efficacy of novel immunotherapies in Alzheimer’s disease (AD), but the lack of methods to examine brain tissues makes it difficult to evaluate therapeutics. Here, we investigated… read more here.
Keywords: brain; transcriptomic brain; brain cells; imaging reveals ... See more keywords