Restoring brain cholesterol turnover improves autophagy and has therapeutic potential in mouse models of spinocerebellar ataxia
Sign Up to like & getrecommendations! Published in 2019 at "Acta Neuropathologica"
DOI: 10.1007/s00401-019-02019-7
Abstract: Spinocerebellar ataxias (SCAs) are devastating neurodegenerative disorders for which no curative or preventive therapies are available. Deregulation of brain cholesterol metabolism and impaired brain cholesterol turnover have been associated with several neurodegenerative diseases. SCA3 or… read more here.
Keywords: cyp46a1; brain cholesterol; sca3; cholesterol ... See more keywords
Disturbances of brain cholesterol metabolism: A new excitotoxic process associated with status epilepticus
Sign Up to like & getrecommendations! Published in 2021 at "Neurobiology of Disease"
DOI: 10.1016/j.nbd.2021.105346
Abstract: The understanding of the excitotoxic processes associated with a severe status epilepticus (SE) is of major importance. Changes of brain cholesterol homeostasis is an emerging candidate for excitotoxicity. We conducted an overall analysis of the… read more here.
Keywords: status epilepticus; brain; brain cholesterol; cholesterol ... See more keywords
Up-regulation of cholesterol 24-hydroxylase following hypoxia-ischemia in neonatal mouse brain
Sign Up to like & getrecommendations! Published in 2018 at "Pediatric research"
DOI: 10.1038/pr.2018.49
Abstract: BackgroundMaintenance of cholesterol homeostasis is crucial for brain development. Brain cholesterol relies on de novo synthesis and is cleared primarily by conversion to 24S-hydroxycholesterol (24S-HC) with brain-specific cholesterol 24-hydroxylase (CYP46A1). We aimed to investigate the… read more here.
Keywords: hypoxia ischemia; brain cholesterol; cholesterol; cholesterol hydroxylase ... See more keywords
Abnormal brain cholesterol homeostasis in Alzheimer’s disease—a targeted metabolomic and transcriptomic study
Sign Up to like & getrecommendations! Published in 2021 at "NPJ Aging and Mechanisms of Disease"
DOI: 10.1038/s41514-021-00064-9
Abstract: The role of brain cholesterol metabolism in Alzheimer’s disease (AD) remains unclear. Peripheral and brain cholesterol levels are largely independent due to the impermeability of the blood brain barrier (BBB), highlighting the importance of studying… read more here.
Keywords: brain cholesterol; disease; cholesterol; cholesterol biosynthesis ... See more keywords
Assessment of cholesterol homeostasis in the living human brain
Sign Up to like & getrecommendations! Published in 2022 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.adc9967
Abstract: Alterations in brain cholesterol homeostasis have been broadly implicated in neurological disorders. Notwithstanding the complexity by which cholesterol biology is governed in the mammalian brain, excess neuronal cholesterol is primarily eliminated by metabolic clearance via… read more here.
Keywords: cholesterol metabolism; brain cholesterol; brain; cholesterol homeostasis ... See more keywords
Regulation of Brain Cholesterol: What Role Do Liver X Receptors Play in Neurodegenerative Diseases?
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms20163858
Abstract: Liver X Receptors (LXR) alpha and beta are two members of nuclear receptor superfamily documented as endogenous cholesterol sensors. Following conversion of cholesterol in oxysterol, both LXR isoforms detect intracellular concentrations and act as transcription… read more here.
Keywords: cholesterol oxysterol; brain cholesterol; cholesterol; liver receptors ... See more keywords