Brain delivery of a virus to block seizures helps mice get a silent NACHT
Sign Up to like & getrecommendations! Published in 2019 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2019.08.066
Abstract: For people with epilepsy, frontline treatment remains with antimice increase levels of Nwd1 and that Nwd1 levels are also higher in seizure drugs (ASDs), a group of over 20 different medicines available for this common,… read more here.
Keywords: block seizures; brain delivery; virus block; seizures helps ... See more keywords
Recent advances in carrier mediated nose‐to‐brain delivery of pharmaceutics
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmaceutics and Biopharmaceutics"
DOI: 10.1016/j.ejpb.2018.05.009
Abstract: Graphical abstract Figure. No caption available. Abstract Central nervous system (CNS) disorders (e.g., multiple sclerosis, Alzheimer’s disease, etc.) represent a growing public health issue, primarily due to the increased life expectancy and the aging population.… read more here.
Keywords: nose brain; brain delivery; delivery; recent advances ... See more keywords
Targeted brain delivery of methotrexate by glutathione PEGylated liposomes: How can the formulation make a difference?
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Pharmaceutics and Biopharmaceutics"
DOI: 10.1016/j.ejpb.2019.04.004
Abstract: ABSTRACT The purpose of this study was to quantitatively investigate how conjugation of GSH to different liposomal formulations influence the brain delivery of methotrexate (MTX) in rats. GSH‐PEG liposomal MTX based on hydrogenated soy phosphatidylcholine… read more here.
Keywords: brain; gsh peg; mtx; brain delivery ... See more keywords
Vitamin-Derived Nanolipoidal Carriers for Brain Delivery of Dimethyl Fumarate: A Novel Approach with Preclinical Evidence.
Sign Up to like & getrecommendations! Published in 2017 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.7b00041
Abstract: Various oral treatment options have been reported for relapsing multiple sclerosis. Recently, dimethyl fumarate (DMF) has been approved for the management of the same. Though effective, DMF is associated with concerns like multiple dosing, patient… read more here.
Keywords: brain delivery; dmf; drug; brain ... See more keywords
Dendrimer Donepezil Conjugates for Improved Brain Delivery and Better in Vivo Pharmacokinetics
Sign Up to like & getrecommendations! Published in 2019 at "ACS Omega"
DOI: 10.1021/acsomega.8b03445
Abstract: In neurodegenerative disorders, crossing the blood-brain barrier to achieve higher brain uptake of drugs has attracted considerable interest of researchers in recent years. The present approach is designed with a hypothesis that polyamidoamine (PAMAM) dendrimer… read more here.
Keywords: donepezil conjugates; brain delivery; dendrimer donepezil; brain ... See more keywords
Stealth lipid polymer hybrid nanoparticles loaded with rutin for effective brain delivery – comparative study with the gold standard (Tween 80): optimization, characterization and biodistribution
Sign Up to like & getrecommendations! Published in 2017 at "Drug Delivery"
DOI: 10.1080/10717544.2017.1410263
Abstract: Abstract The blood–brain barrier is considered the leading physiological obstacle hindering the transport of neurotherapeutics to brain cells. The application of nanotechnology coupled with surfactant coating is one of the efficacious tactics overcoming this barrier.… read more here.
Keywords: brain delivery; lipid polymer; delivery; study ... See more keywords
Brain delivery of quercetin-loaded exosomes improved cognitive function in AD mice by inhibiting phosphorylated tau-mediated neurofibrillary tangles
Sign Up to like & getrecommendations! Published in 2020 at "Drug Delivery"
DOI: 10.1080/10717544.2020.1762262
Abstract: Abstract It is reported that quercetin (Que) can prevent tau pathology and induce neuroprotection by improving cognitive and functional symptoms in the treatment of Alzheimer’s disease (AD). However, its clinical application has been limited due… read more here.
Keywords: tau; brain delivery; que; neurofibrillary tangles ... See more keywords
Direct nose to brain delivery of small molecules: critical analysis of data from a standardized in vivo screening model in rats
Sign Up to like & getrecommendations! Published in 2020 at "Drug Delivery"
DOI: 10.1080/10717544.2020.1837291
Abstract: Abstract The blood–brain barrier (BBB) is often a limiting factor for getting drugs in the brain. Bypassing the BBB by intranasal (IN), or also called nose to brain (NTB), route is an interesting and frequently… read more here.
Keywords: brain delivery; delivery; small molecules; brain ... See more keywords
Nose to brain delivery of melatonin lipidic nanocapsules as a promising post-ischemic neuroprotective therapeutic modality
Sign Up to like & getrecommendations! Published in 2022 at "Drug Delivery"
DOI: 10.1080/10717544.2022.2104405
Abstract: Abstract Ischemic stroke accounts for about 87% of all strokes, causing long-term disability in adults, and is the second leading cause of death worldwide. In search of new therapeutic modalities, the use of neuroprotective agents… read more here.
Keywords: lipidic nanocapsules; post ischemic; nose brain; brain delivery ... See more keywords
Nanonized carbamazepine for nose-to-brain delivery: pharmaceutical formulation development
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceutical Development and Technology"
DOI: 10.1080/10837450.2023.2177673
Abstract: Abstract Epilepsy is one of the most common neurological disorders in the world. The therapeutic treatment is challenging since conventional drugs have limited efficacy and several side effects that impair patient management. Efforts are being… read more here.
Keywords: cbz ncs; formulation; brain; nose brain ... See more keywords
Nose-to-brain drug delivery for the treatment of Alzheimer’s disease: current advancements and challenges
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Drug Delivery"
DOI: 10.1080/17425247.2022.2029845
Abstract: ABSTRACT Introduction The irreversible destruction of neurons, progressive loss of memory and cognitive behavior, high cost of therapy, and impact on society, desire a better, effective, and affordable treatment of AD. The nose-to-brain delivery approach… read more here.
Keywords: drug; delivery; brain delivery; nose brain ... See more keywords