Endocannabinoid signaling in brain diseases: Emerging relevance of glial cells
Sign Up to like & getrecommendations! Published in 2022 at "Glia"
DOI: 10.1002/glia.24172
Abstract: The discovery of cannabinoid receptors as the primary molecular targets of psychotropic cannabinoid Δ9‐tetrahydrocannabinol (Δ9‐THC) in late 1980s paved the way for investigations on the effects of cannabis‐based therapeutics in brain pathology. Ever since, a… read more here.
Keywords: signaling brain; relevance; brain; glial cells ... See more keywords
Brain-targeting drug delivery systems.
Sign Up to like & getrecommendations! Published in 2022 at "Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology"
DOI: 10.1002/wnan.1818
Abstract: Brain diseases, including neurodegenerative diseases, acute ischemic stroke and brain tumors, have become a major health problem and a huge burden on society with high morbidity and mortality. However, most of the current therapeutic drugs… read more here.
Keywords: brain targeting; delivery systems; brain; drug ... See more keywords
Acute Brain Diseases as Triggers for Stress Cardiomyopathy: Clinical Characteristics and Outcomes
Sign Up to like & getrecommendations! Published in 2017 at "Neurocritical Care"
DOI: 10.1007/s12028-017-0412-9
Abstract: ObjectiveTo determine the clinical characteristics and outcomes of patients with neurogenic stress cardiomyopathy (NSC) among patients admitted to our neuroscience intensive care unit (NICU).MethodsFollowing institutional review board approval, consecutive adult patients admitted to the NICU… read more here.
Keywords: acute brain; characteristics outcomes; stress cardiomyopathy; brain diseases ... See more keywords
The Roles of Peroxiredoxin 6 in Brain Diseases.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular neurobiology"
DOI: 10.1007/s12035-021-02427-5
Abstract: Peroxiredoxin 6 (PRDX6), the only mammalian 1-Cys member of the peroxiredoxins (PRDXs) family, has multiple functions of glutathione peroxidase (Gpx) activity, acidic calcium-independent phospholipase (aiPLA2) activity, and lysophosphatidylcholine acyl transferase (LPCAT) activity. It has been… read more here.
Keywords: roles peroxiredoxin; peroxiredoxin brain; brain diseases; brain ... See more keywords
Treating brain diseases using systemic parenterally-administered protein therapeutics: Dysfunction of the brain barriers and potential strategies.
Sign Up to like & getrecommendations! Published in 2020 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2020.120461
Abstract: The parenteral administration of protein therapeutics is increasingly gaining importance for the treatment of human diseases. However, the presence of practically impermeable blood-brain barriers greatly restricts access of such pharmaceutics to the brain. Treating brain… read more here.
Keywords: protein therapeutics; treating brain; brain diseases; brain barriers ... See more keywords
Engineered Bioluminescent Indicator Enables the Brain Imaging of Kinase Inhibitors
Sign Up to like & getrecommendations! Published in 2023 at "ACS Central Science"
DOI: 10.1021/acscentsci.3c00367
Abstract: With the emergence of an aging society, brain diseases such as brain tumors, Alzheimer’s disease (AD), Parkinson’s disease (PD), and stroke account for an increasing proportion of global diseases, resulting in a growing demand for… read more here.
Keywords: drug concentration; brain; kinase; drug development ... See more keywords
Lipid nanoparticles for intranasal administration: application to nose-to-brain delivery
Sign Up to like & getrecommendations! Published in 2018 at "Expert Opinion on Drug Delivery"
DOI: 10.1080/17425247.2018.1429401
Abstract: ABSTRACT Introduction: The blood brain barrier is a functional barrier allowing the entry into the brain of only essential nutrients, excluding other molecules. Its structure, although essential to keep the harmful entities out, is also… read more here.
Keywords: drug delivery; delivery; delivery systems; brain diseases ... See more keywords
BrainBase: a curated knowledgebase for brain diseases.
Sign Up to like & getrecommendations! Published in 2021 at "Nucleic acids research"
DOI: 10.1093/nar/gkab987
Abstract: Brain is the central organ of the nervous system and any brain disease can seriously affect human health. Here we present BrainBase (https://ngdc.cncb.ac.cn/brainbase), a curated knowledgebase for brain diseases that aims to provide a whole… read more here.
Keywords: brain diseases; brain; brainbase curated; knowledgebase brain ... See more keywords
Imaging of Childhood Inflammatory Brain Diseases
Sign Up to like & getrecommendations! Published in 2018 at "Topics in Magnetic Resonance Imaging"
DOI: 10.1097/rmr.0000000000000187
Abstract: Abstract Brain has been considered as an immune-privileged site for centuries owing to the presence of blood-brain barrier, absent lymphatic drainage, and antigen-presenting cells. However, the present prevailing concept is of immune surveillance where brain… read more here.
Keywords: imaging childhood; childhood inflammatory; inflammatory; inflammatory brain ... See more keywords
Brain lipidomics: From functional landscape to clinical significance
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.adc9317
Abstract: Lipids are crucial components of cellular function owing to their role in membrane formation, intercellular signaling, energy storage, and homeostasis maintenance. In the brain, lipid dysregulations have been associated with the etiology and progression of… read more here.
Keywords: brain lipidomics; brain; significance; functional landscape ... See more keywords
A comparison of anatomic and cellular transcriptome structures across 40 human brain diseases
Sign Up to like & getrecommendations! Published in 2023 at "PLOS Biology"
DOI: 10.1371/journal.pbio.3002058
Abstract: Genes associated with risk for brain disease exhibit characteristic expression patterns that reflect both anatomical and cell type relationships. Brain-wide transcriptomic patterns of disease risk genes provide a molecular-based signature, based on differential co-expression, that… read more here.
Keywords: disease; brain; expression; human brain ... See more keywords