A Review of the Cholinergic System and Therapeutic Approaches to Treat Brain Disorders.
Sign Up to like & getrecommendations! Published in 2020 at "Current topics in behavioral neurosciences"
DOI: 10.1007/7854_2020_141
Abstract: Since its identification over a hundred years ago, the neurotransmitter acetylcholine (ACh) has proven to play an essential role in supporting many diverse functions. Some well-characterized functions include: chemical transmission at the neuromuscular junction; autonomic… read more here.
Keywords: system; review cholinergic; system therapeutic; brain disorders ... See more keywords
Brain-Derived Neurotrophic Factor in Brain Disorders: Focus on Neuroinflammation
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Neurobiology"
DOI: 10.1007/s12035-018-1283-6
Abstract: Brain-derived neurotrophic factor (BDNF) is one of the most studied neurotrophins in the healthy and diseased brain. As a result, there is a large body of evidence that associates BDNF with neuronal maintenance, neuronal survival,… read more here.
Keywords: brain derived; derived neurotrophic; neuroinflammation; brain disorders ... See more keywords
Abnormal repetitive behaviors in zebrafish and their relevance to human brain disorders
Sign Up to like & getrecommendations! Published in 2019 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2019.03.044
Abstract: Abnormal repetitive behaviors (ARBs) are a prominent symptom of numerous human brain disorders and are commonly seen in rodent models as well. While rodent studies of ARBs continue to dominate the field, mounting evidence suggests… read more here.
Keywords: abnormal repetitive; behaviors zebrafish; human brain; brain disorders ... See more keywords
Building Models of Brain Disorders with Three-Dimensional Organoids
Sign Up to like & getrecommendations! Published in 2018 at "Neuron"
DOI: 10.1016/j.neuron.2018.10.007
Abstract: Disorders of the nervous system are challenging to study and treat due to the relative inaccessibility of functional human brain tissue for research. Stem cell-derived 3D human brain organoids have the potential to recapitulate features… read more here.
Keywords: models brain; building models; disorders three; human brain ... See more keywords
Molecular landscape of long noncoding RNAs in brain disorders
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Psychiatry"
DOI: 10.1038/s41380-020-00947-5
Abstract: According to current paradigms, various risk factors, such as genetic mutations, oxidative stress, neural network dysfunction, and abnormal protein degradation, contribute to the progression of brain disorders. Through the cooperation of gene transcripts in biological… read more here.
Keywords: long noncoding; brain disorders; molecular landscape; noncoding rnas ... See more keywords
Emerging connections between cerebellar development, behaviour and complex brain disorders
Sign Up to like & getrecommendations! Published in 2019 at "Nature Reviews Neuroscience"
DOI: 10.1038/s41583-019-0152-2
Abstract: The human cerebellum has a protracted developmental timeline compared with the neocortex, expanding the window of vulnerability to neurological disorders. As the cerebellum is critical for motor behaviour, it is not surprising that most neurodevelopmental disorders… read more here.
Keywords: brain disorders; motor; cerebellar development; behaviour ... See more keywords
The depressor axis of the renin-angiotensin system and brain disorders: a translational approach.
Sign Up to like & getrecommendations! Published in 2018 at "Clinical science"
DOI: 10.1042/cs20180189
Abstract: All the components of the classic renin-angiotensin system (RAS) have been identified in the brain. Today, the RAS is considered to be composed mainly of two axes: the pressor axis, represented by angiotensin (Ang) II/angiotensin-converting… read more here.
Keywords: brain disorders; renin angiotensin; angiotensin; angiotensin system ... See more keywords
Oleanolic acid and ursolic acid: therapeutic potential in neurodegenerative diseases, neuropsychiatric diseases and other brain disorders
Sign Up to like & getrecommendations! Published in 2022 at "Nutritional Neuroscience"
DOI: 10.1080/1028415x.2022.2051957
Abstract: ABSTRACT Brain disorders such as neurodegenerative diseases and neuropsychiatric diseases have become serious threatens to human health and quality of life. Oleanolic acid (OA) and ursolic acid (UA) are pentacyclic triterpenoid isomers widely distributed in… read more here.
Keywords: neuropsychiatric diseases; brain; diseases neuropsychiatric; neurodegenerative diseases ... See more keywords
Pharmacogenomics of drugs used to treat brain disorders
Sign Up to like & getrecommendations! Published in 2020 at "Expert Review of Precision Medicine and Drug Development"
DOI: 10.1080/23808993.2020.1738217
Abstract: ABSTRACT Introduction Neuropsychiatric disorders (NPDs) (neurodevelopmental, mental, neurodegenerative, neurotoxic, complex disorders) are the third major problem of health in developed countries. About 10-20% of direct costs are attributed to pharmacological treatment; however, drug effectiveness is… read more here.
Keywords: drugs used; used treat; drug; brain disorders ... See more keywords
Deep learning for brain disorders: from data processing to disease treatment
Sign Up to like & getrecommendations! Published in 2021 at "Briefings in bioinformatics"
DOI: 10.1093/bib/bbaa310
Abstract: In order to reach precision medicine and improve patients' quality of life, machine learning is increasingly used in medicine. Brain disorders are often complex and heterogeneous, and several modalities such as demographic, clinical, imaging, genetics… read more here.
Keywords: medicine; processing; learning brain; deep learning ... See more keywords
Cryptic mutations of PLC family members in brain disorders: recent discoveries and a deep-learning-based approach
Sign Up to like & getrecommendations! Published in 2022 at "Brain"
DOI: 10.1093/brain/awac451
Abstract: Abstract Phospholipase C (PLC) is an essential isozyme involved in the phosphoinositide signalling pathway, which maintains cellular homeostasis. Gain- and loss-of-function mutations in PLC affect enzymatic activity and are therefore associated with several disorders. Alternative… read more here.
Keywords: mutations plc; brain; deep learning; learning based ... See more keywords