Therapeutic potential of saffron in brain disorders: From bench to bedside
Sign Up to like & getrecommendations! Published in 2024 at "Phytotherapy Research"
DOI: 10.1002/ptr.8169
Abstract: Saffron is a spice derived from the flower of Crocus sativus L., which has been used for centuries as a coloring and flavoring agent, as well as a source of medicinal compounds. Saffron contains various… read more here.
Keywords: potential saffron; brain disorders; brain; therapeutic potential ... See more keywords
A Review of the Cholinergic System and Therapeutic Approaches to Treat Brain Disorders.
Sign Up to like & getrecommendations! Published in 2020 at "Current topics in behavioral neurosciences"
DOI: 10.1007/7854_2020_141
Abstract: Since its identification over a hundred years ago, the neurotransmitter acetylcholine (ACh) has proven to play an essential role in supporting many diverse functions. Some well-characterized functions include: chemical transmission at the neuromuscular junction; autonomic… read more here.
Keywords: system; review cholinergic; system therapeutic; brain disorders ... See more keywords
Brain-Derived Neurotrophic Factor in Brain Disorders: Focus on Neuroinflammation
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Neurobiology"
DOI: 10.1007/s12035-018-1283-6
Abstract: Brain-derived neurotrophic factor (BDNF) is one of the most studied neurotrophins in the healthy and diseased brain. As a result, there is a large body of evidence that associates BDNF with neuronal maintenance, neuronal survival,… read more here.
Keywords: brain derived; derived neurotrophic; neuroinflammation; brain disorders ... See more keywords
Abnormal repetitive behaviors in zebrafish and their relevance to human brain disorders
Sign Up to like & getrecommendations! Published in 2019 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2019.03.044
Abstract: Abnormal repetitive behaviors (ARBs) are a prominent symptom of numerous human brain disorders and are commonly seen in rodent models as well. While rodent studies of ARBs continue to dominate the field, mounting evidence suggests… read more here.
Keywords: abnormal repetitive; behaviors zebrafish; human brain; brain disorders ... See more keywords
Building Models of Brain Disorders with Three-Dimensional Organoids
Sign Up to like & getrecommendations! Published in 2018 at "Neuron"
DOI: 10.1016/j.neuron.2018.10.007
Abstract: Disorders of the nervous system are challenging to study and treat due to the relative inaccessibility of functional human brain tissue for research. Stem cell-derived 3D human brain organoids have the potential to recapitulate features… read more here.
Keywords: models brain; building models; disorders three; human brain ... See more keywords
Molecular landscape of long noncoding RNAs in brain disorders
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Psychiatry"
DOI: 10.1038/s41380-020-00947-5
Abstract: According to current paradigms, various risk factors, such as genetic mutations, oxidative stress, neural network dysfunction, and abnormal protein degradation, contribute to the progression of brain disorders. Through the cooperation of gene transcripts in biological… read more here.
Keywords: long noncoding; brain disorders; molecular landscape; noncoding rnas ... See more keywords
Decoding the genomic symphony: unravelling brain disorders through data integration and machine learning
Sign Up to like & getrecommendations! Published in 2025 at "Molecular Psychiatry"
DOI: 10.1038/s41380-025-03330-4
Abstract: Machine learning (ML) is revolutionising our ability to decode the complex genetic architectures of brain disorders. In this review we examine the strengths and limitations of ML methods, highlighting their applications in genetic prediction, patient… read more here.
Keywords: brain; brain disorders; machine learning; genomic symphony ... See more keywords
Emerging connections between cerebellar development, behaviour and complex brain disorders
Sign Up to like & getrecommendations! Published in 2019 at "Nature Reviews Neuroscience"
DOI: 10.1038/s41583-019-0152-2
Abstract: The human cerebellum has a protracted developmental timeline compared with the neocortex, expanding the window of vulnerability to neurological disorders. As the cerebellum is critical for motor behaviour, it is not surprising that most neurodevelopmental disorders… read more here.
Keywords: brain disorders; motor; cerebellar development; behaviour ... See more keywords
The depressor axis of the renin-angiotensin system and brain disorders: a translational approach.
Sign Up to like & getrecommendations! Published in 2018 at "Clinical science"
DOI: 10.1042/cs20180189
Abstract: All the components of the classic renin-angiotensin system (RAS) have been identified in the brain. Today, the RAS is considered to be composed mainly of two axes: the pressor axis, represented by angiotensin (Ang) II/angiotensin-converting… read more here.
Keywords: brain disorders; renin angiotensin; angiotensin; angiotensin system ... See more keywords
Oleanolic acid and ursolic acid: therapeutic potential in neurodegenerative diseases, neuropsychiatric diseases and other brain disorders
Sign Up to like & getrecommendations! Published in 2022 at "Nutritional Neuroscience"
DOI: 10.1080/1028415x.2022.2051957
Abstract: ABSTRACT Brain disorders such as neurodegenerative diseases and neuropsychiatric diseases have become serious threatens to human health and quality of life. Oleanolic acid (OA) and ursolic acid (UA) are pentacyclic triterpenoid isomers widely distributed in… read more here.
Keywords: neuropsychiatric diseases; brain; diseases neuropsychiatric; neurodegenerative diseases ... See more keywords
Pharmacogenomics of drugs used to treat brain disorders
Sign Up to like & getrecommendations! Published in 2020 at "Expert Review of Precision Medicine and Drug Development"
DOI: 10.1080/23808993.2020.1738217
Abstract: ABSTRACT Introduction Neuropsychiatric disorders (NPDs) (neurodevelopmental, mental, neurodegenerative, neurotoxic, complex disorders) are the third major problem of health in developed countries. About 10-20% of direct costs are attributed to pharmacological treatment; however, drug effectiveness is… read more here.
Keywords: drugs used; used treat; drug; brain disorders ... See more keywords