Various brain-eating amoebae: the protozoa, the pathogenesis, and the disease
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers of Medicine"
DOI: 10.1007/s11684-021-0865-2
Abstract: Among various genera of free-living amoebae prevalent in nature, some members are identified as causative agents of human encephalitis, in which Naegleria fowleri followed by Acanthamoeba spp. and Balamuthia mandrillaris have been successively discovered. As… read more here.
Keywords: various brain; eating amoebae; disease; pathogenesis ... See more keywords
Aryl Quinazolinone Derivatives as Novel Therapeutic Agents against Brain-Eating Amoebae.
Sign Up to like & getrecommendations! Published in 2020 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.9b00596
Abstract: Naegleria fowleri and Balamuthia mandrillaris are protist pathogens that infect the central nervous system, causing primary amoebic meningoencephalitis and granulomatous amoebic encephalitis with mortality rates of over 95%. Quinazolinones and their derivatives possess a wide… read more here.
Keywords: quinazolinone derivatives; eating amoebae; derivatives novel; aryl quinazolinone ... See more keywords
Gold-Conjugated Curcumin as a Novel Therapeutic Agent against Brain-Eating Amoebae
Sign Up to like & getrecommendations! Published in 2020 at "ACS Omega"
DOI: 10.1021/acsomega.0c01305
Abstract: Balamuthia mandrillaris and Naegleria fowleri are free-living amoebae that cause infection of the central nervous system, granulomatous amoebic encephalitis (GAE) and primary amoebic meningoencephalitis (PAM), respectively. The fact that mortality rates for cases of GAE… read more here.
Keywords: gold conjugated; eating amoebae; conjugated curcumin; brain eating ... See more keywords
Applications of Polyaniline-Based Molybdenum Disulfide Nanoparticles against Brain-Eating Amoebae
Sign Up to like & getrecommendations! Published in 2023 at "ACS Omega"
DOI: 10.1021/acsomega.2c06050
Abstract: Primary amoebic meningoencephalitis and granulomatous amoebic encephalitis are distressing infections of the central nervous system caused by brain-eating amoebae, namely, Naegleria fowleri and Acanthamoeba spp., respectively, and present mortality rates of over 90%. No single… read more here.
Keywords: brain eating; eating amoebae; molybdenum disulfide;
Azole and 5-nitroimidazole based nanoformulations are potential antiamoebic drug candidates against brain eating amoebae.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of applied microbiology"
DOI: 10.1093/jambio/lxad072
Abstract: AIM Herein, the anti-parasitic activity of azoles (fluconazole and itraconazole) and 5-nitroimdazole (metronidazole) against brain eating amoebae: Naegleria fowleri and Balamuthia mandrillaris was elucidated. METHODS AND RESULTS Azoles and 5-nitroimdazole based nanoformulations were synthesized and… read more here.
Keywords: azole nitroimidazole; based nanoformulations; brain eating; nitroimidazole based ... See more keywords
In-silico drug design for the novel Karachi-NF001 strain of brain-eating amoeba: Naegleria fowleri
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2023.1098217
Abstract: Naegleria fowleri (N. fowleri) is a free-living thermophilic amoeba of fresh water and soil. The amoeba primarily feeds on bacteria but can be transmitted to humans upon contact with freshwater sources. Furthermore, this brain-eating amoeba… read more here.
Keywords: naegleria fowleri; nf001 strain; brain; brain eating ... See more keywords
Zinc Oxide Nanoconjugates against Brain-Eating Amoebae
Sign Up to like & getrecommendations! Published in 2022 at "Antibiotics"
DOI: 10.3390/antibiotics11101281
Abstract: Naegleria fowleri and Balamuthia mandrillaris are opportunistic protists, responsible for fatal central nervous system infections such as primary amoebic meningoencephalitis (PAM) and granulomatous amoebic encephalitis (GAE) with mortality rates higher than 90%. Threatening a rise… read more here.
Keywords: nanoconjugates brain; brain eating; zno; eating amoebae ... See more keywords
Imidazothiazole Derivatives Exhibited Potent Effects against Brain-Eating Amoebae
Sign Up to like & getrecommendations! Published in 2022 at "Antibiotics"
DOI: 10.3390/antibiotics11111515
Abstract: Naegleria fowleri (N. fowleri) is a free-living, unicellular, opportunistic protist responsible for the fatal central nervous system infection, primary amoebic meningoencephalitis (PAM). Given the increase in temperatures due to global warming and climate change, it… read more here.
Keywords: derivatives exhibited; imidazothiazole derivatives; brain eating; exhibited potent ... See more keywords