Demystifying the extracellular matrix and its proteolytic remodeling in the brain: structural and functional insights
Sign Up to like & getrecommendations! Published in 2019 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-019-03182-6
Abstract: The extracellular matrix (ECM) plays diverse roles in several physiological and pathological conditions. In the brain, the ECM is unique both in its composition and in functions. Furthermore, almost all the cells in the central… read more here.
Keywords: brain ecm; extracellular matrix; matrix; demystifying extracellular ... See more keywords
Changes in the Brain Extracellular Matrix Composition in schizophrenia: A Pathophysiological Dysregulation and a Potential Therapeutic Target.
Sign Up to like & getrecommendations! Published in 2021 at "Cellular and molecular neurobiology"
DOI: 10.1007/s10571-021-01073-8
Abstract: The brain extracellular matrix (ECM) is involved in crucial processes of neural support, neuronal and synaptic plasticity, extrasynaptic transmission, and neurotransmission. ECM is a tridimensional fibrillary meshwork composed of macromolecules that determine its bioactivity and… read more here.
Keywords: brain ecm; extracellular matrix; brain extracellular; pathophysiological dysregulation ... See more keywords
Identification of variable lymphocyte receptors that can target therapeutics to pathologically exposed brain extracellular matrix
Sign Up to like & getrecommendations! Published in 2019 at "Science Advances"
DOI: 10.1126/sciadv.aau4245
Abstract: This study demonstrates targeting of blood-brain barrier disruption to deliver payloads at sites of neurological disease. Diseases that lead to blood-brain barrier (BBB) disruption will pathologically expose normally inaccessible brain extracellular matrix (ECM) to circulating… read more here.
Keywords: brain ecm; extracellular matrix; brain extracellular; variable lymphocyte ... See more keywords