Tetrahydrocurcumin ameliorates homocysteine‐mediated mitochondrial remodeling in brain endothelial cells
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.26145
Abstract: Homocysteine (Hcy) causes endothelial dysfunction by inducing oxidative stress in most neurodegenerative disorders. This dysfunction is highly correlated with mitochondrial dynamics such as fusion and fission. However, there are no strategies to prevent Hcy‐induced mitochondrial… read more here.
Keywords: hcy; microscopy; brain endothelial; thc ... See more keywords
In Vitro Models for Studying the Interaction of Neisseria meningitidis with Human Brain Endothelial Cells.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9202-7_10
Abstract: Bacterial meningitis is a serious, life-threatening infection of the central nervous system (CNS). To cause meningitis, bacteria must interact with and penetrate the meningeal blood-cerebrospinal fluid barrier (mB/CSFB), which comprises highly specialized brain endothelial cells.… read more here.
Keywords: brain endothelial; endothelial cells; interaction; neisseria meningitidis ... See more keywords
NEO212, a conjugate of temozolomide and perillyl alcohol, blocks the endothelial-to-mesenchymal transition in tumor-associated brain endothelial cells in glioblastoma.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer letters"
DOI: 10.1016/j.canlet.2018.10.034
Abstract: As the endothelial-to-mesenchymal transition (EndMT) supports the pro-angiogenic and invasive characteristics of glioblastoma multiforme (GBM), blocking this process would be a promising approach to inhibit tumor progression and recurrence. Here, we demonstrate that glioma stem… read more here.
Keywords: mesenchymal transition; endothelial mesenchymal; brain endothelial; endothelial cells ... See more keywords
Glioma-Derived miRNA-Containing Extracellular Vesicles Induce Angiogenesis by Reprogramming Brain Endothelial Cells.
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.01.073
Abstract: Glioblastoma (GBM) is characterized by aberrant vascularization and a complex tumor microenvironment. The failure of anti-angiogenic therapies suggests pathways of GBM neovascularization, possibly attributable to glioblastoma stem cells (GSCs) and their interplay with the tumor… read more here.
Keywords: extracellular vesicles; gsc evs; angiogenesis; brain endothelial ... See more keywords
Nrf2 redox signalling in brain endothelial cells adapted to physiological O2: an in vitro model for ischaemia-reperfusion injury in stroke
Sign Up to like & getrecommendations! Published in 2018 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.04.435
Abstract: Sulforaphane (SFN) has been shown to protect against damage sustained following transient ischaemic stroke via activation of the redox-sensitive transcription factor Nrf2. To further understand the protective effects of SFN on the cerebral endothelium, mouse… read more here.
Keywords: vitro model; redox; brain endothelial; bend cells ... See more keywords
Neurolymphatic biomarkers of brain endothelial inflammatory activation: Implications for multiple sclerosis diagnosis.
Sign Up to like & getrecommendations! Published in 2019 at "Life sciences"
DOI: 10.1016/j.lfs.2019.05.021
Abstract: AIMS Multiple sclerosis (MS) is the leading cause of non-traumatic neurological disability in young adults, and its diagnosis is often delayed due to the lack of diagnostic markers. Initiation of disease -modifying therapy in the… read more here.
Keywords: diagnosis; brain endothelial; multiple sclerosis; expression ... See more keywords
Dynamin-2 mediates clathrin-dependent endocytosis for amyloid-β internalization in brain microvascular endothelial cells.
Sign Up to like & getrecommendations! Published in 2021 at "Microvascular research"
DOI: 10.1016/j.mvr.2021.104219
Abstract: Dynamin is recognized as a crucial regulator for membrane fission and has three isoforms in mammals. But the expression patterns of dynamin isoforms and their roles in non-neuronal cells are incompletely understood. In this study,… read more here.
Keywords: internalization; clathrin dependent; brain endothelial; endocytosis ... See more keywords
Characterization of basigin monoclonal antibodies for receptor-mediated drug delivery to the brain
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-71286-2
Abstract: The brain uptake of biotherapeutics for brain diseases is hindered by the blood–brain barrier (BBB). The BBB selectively regulates the transport of large molecules into the brain and thereby maintains brain homeostasis. Receptor-mediated transcytosis (RMT)… read more here.
Keywords: monoclonal antibodies; brain endothelial; brain; epitope ... See more keywords
Prostaglandin E2 Production by Brain Endothelial Cells and the Generation of Fever
Sign Up to like & getrecommendations! Published in 2023 at "DNA and Cell Biology"
DOI: 10.1089/dna.2022.0662
Abstract: We recently demonstrated that prostaglandin production in brain endothelial cells is both necessary and sufficient for the generation of fever during systemic immune challenge. I here discuss this finding in light of the previous literature… read more here.
Keywords: generation fever; endothelial cells; prostaglandin production; production brain ... See more keywords
MCAM+ brain endothelial cells contribute to neuroinflammation by recruiting pathogenic CD4+ T lymphocytes
Sign Up to like & getrecommendations! Published in 2022 at "Brain"
DOI: 10.1093/brain/awac389
Abstract: Abstract The trafficking of autoreactive leucocytes across the blood–brain barrier endothelium is a hallmark of multiple sclerosis pathogenesis. Although the blood–brain barrier endothelium represents one of the main CNS borders to interact with the infiltrating… read more here.
Keywords: endothelial cells; blood brain; brain barrier; brain ... See more keywords
Brain endothelial STING1 activation by Plasmodium-sequestered heme promotes cerebral malaria via type I IFN response
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1101/2022.02.14.480268
Abstract: Cerebral malaria (CM) is a life-threatening form of Plasmodium falciparum infection caused by brain inflammation. Brain endothelium dysfunction is a hallmark of CM pathology, which is also associated with the activation of the type I… read more here.
Keywords: plasmodium; brain; ifn; type ... See more keywords