Interferon-ɣ mediated signaling in the brain endothelium is critical for inflammation-induced aversion
Sign Up to like & getrecommendations! Published in 2018 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2017.08.020
Abstract: Systemic inflammation elicits malaise and a negative affective state. The mechanism underpinning the aversive component of inflammation include cerebral prostaglandin synthesis and modulation of dopaminergic reward circuits, but the messengers that mediate the signaling between… read more here.
Keywords: inflammation; induced aversion; brain endothelium; inflammation induced ... See more keywords
Modulation of in vitro Brain Endothelium by Mechanical Trauma: Structural and Functional Restoration by Poloxamer 188
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-59888-2
Abstract: Brain injuries caused by an explosive blast or blunt force is typically presumed to associate with mechanical trauma to the brain tissue. Recent findings from our laboratory suggest that shockwaves produced by a blast can… read more here.
Keywords: mechanical trauma; structural functional; brain endothelium; poloxamer 188 ... See more keywords
Brain vasculature disturbance in schizophrenia
Sign Up to like & getrecommendations! Published in 2022 at "Current Opinion in Psychiatry"
DOI: 10.1097/yco.0000000000000789
Abstract: Purpose of review The vascular hypothesis of schizophrenia (SZ) postulates that brain endothelial dysfunction contributes to brain pathophysiology. This review discusses recent evidence for and against this hypothesis, including data related to blood–brain barrier (BBB),… read more here.
Keywords: vasculature disturbance; brain vasculature; brain endothelium; endothelium ... See more keywords
miR-27a-3p regulates expression of intercellular junctions at the brain endothelium and controls the endothelial barrier permeability
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0262152
Abstract: Background The brain endothelial barrier permeability is governed by tight and adherens junction protein complexes that restrict paracellular permeability at the blood-brain barrier (BBB). Dysfunction of the inter-endothelial junctions has been implicated in neurological disorders… read more here.
Keywords: brain endothelium; barrier; brain; permeability ... See more keywords
Molecular Heterogeneity of the Brain Endothelium
Sign Up to like & getrecommendations! Published in 2023 at "Current Issues in Molecular Biology"
DOI: 10.3390/cimb45040227
Abstract: The blood–brain barrier (BBB) is part of a neurovascular structure located in the brain’s micro vessels, that is essential to maintain brain homeostasis, but prevents the brain uptake of most drugs. Because of its importance… read more here.
Keywords: bbb; structure; brain endothelium; brain ... See more keywords
Adhesion to the Brain Endothelium Selects Breast Cancer Cells with Brain Metastasis Potential
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24087087
Abstract: Tumor cells metastasize from a primary lesion to distant organs mainly through hematogenous dissemination, in which tumor cell re-adhesion to the endothelium is essential before extravasating into the target site. We thus hypothesize that tumor… read more here.
Keywords: adhesion; tumor cells; brain; brain endothelium ... See more keywords